DE69434290D1 - Stabilisierung von proteinen in lösung - Google Patents

Stabilisierung von proteinen in lösung

Info

Publication number
DE69434290D1
DE69434290D1 DE69434290T DE69434290T DE69434290D1 DE 69434290 D1 DE69434290 D1 DE 69434290D1 DE 69434290 T DE69434290 T DE 69434290T DE 69434290 T DE69434290 T DE 69434290T DE 69434290 D1 DE69434290 D1 DE 69434290D1
Authority
DE
Germany
Prior art keywords
alkyl
pct
sec
hydroxyalkyl
sulphonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434290T
Other languages
English (en)
Other versions
DE69434290T2 (de
Inventor
David Gibson
Leigh Pierce
Irene Webster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Leeds Innovations Ltd
Original Assignee
University of Leeds Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Leeds Innovations Ltd filed Critical University of Leeds Innovations Ltd
Publication of DE69434290D1 publication Critical patent/DE69434290D1/de
Application granted granted Critical
Publication of DE69434290T2 publication Critical patent/DE69434290T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69434290T 1993-10-08 1994-10-06 Stabilisierung von proteinen in lösung Expired - Lifetime DE69434290T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9320782 1993-10-08
GB939320782A GB9320782D0 (en) 1993-10-08 1993-10-08 Stabilising of proteins on solution
PCT/GB1994/002180 WO1995010605A1 (en) 1993-10-08 1994-10-06 Stabilisation of proteins in solution

Publications (2)

Publication Number Publication Date
DE69434290D1 true DE69434290D1 (de) 2005-04-14
DE69434290T2 DE69434290T2 (de) 2005-12-29

Family

ID=10743227

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434290T Expired - Lifetime DE69434290T2 (de) 1993-10-08 1994-10-06 Stabilisierung von proteinen in lösung

Country Status (8)

Country Link
US (1) US6133229A (de)
EP (1) EP0722492B1 (de)
AT (1) ATE290590T1 (de)
AU (1) AU7817094A (de)
DE (1) DE69434290T2 (de)
DK (1) DK0722492T3 (de)
GB (1) GB9320782D0 (de)
WO (1) WO1995010605A1 (de)

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JP2004525369A (ja) * 2001-03-07 2004-08-19 インスツルメンテーション ラボラトリー カンパニー 参照電極
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US6960466B2 (en) * 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
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US6737401B2 (en) * 2001-06-28 2004-05-18 Metronic Minimed, Inc. Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom
US7422903B2 (en) * 2002-12-11 2008-09-09 Instrumentation Laboratory Company Multi-analyte reference solutions
US20040256227A1 (en) * 2003-02-11 2004-12-23 Jungwon Shin Electrochemical urea sensors and methods of making the same
US20040154933A1 (en) * 2003-02-11 2004-08-12 Instrumentation Laboratory Company Polymeric membranes for use in electrochemical sensors
CN102940879B (zh) * 2003-06-03 2017-06-06 诺沃挪第克公司 稳定化的药物肽组合物
WO2004105790A1 (en) 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
WO2005049061A2 (en) 2003-11-20 2005-06-02 Novo Nordisk A/S Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
SG151298A1 (en) 2004-04-08 2009-04-30 Biomatrica Inc Integration of sample storage and sample management for life science
US7740861B2 (en) * 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
ES2442223T3 (es) 2004-08-31 2014-02-10 Novo Nordisk A/S Uso de tris(hidroximetil) aminometano para la estabilización de péptidos, polipéptidos y proteínas
CA2580537C (en) 2004-09-17 2015-04-21 University Of Massachusetts Compositions and their uses for lysosomal enzyme deficiencies
BRPI0517341A (pt) 2004-11-12 2008-10-07 Novo Nordisk As composição farmacêutica estável em prateleira, métodos para a preparação de uma composição farmacêutica, para o tratamento de hiperglicemia, para o tratamento de obesidade, deficiência de célula beta, igt ou dislipidemia, para a preparação de uma solução estável de um composto glp-1, para a preparação de um composto glp-1 estável e para a preparação de uma composição farmacêutica estável em prateleira de um composto glp-1, solução estável de um composto glp-1, e, uso de uma solução estável de um composto glp-1
AU2006247188A1 (en) 2005-05-18 2006-11-23 Children's Hospital & Research Center At Oakland Methods and compositions for immunizing against chlamydia infection
US20070031914A1 (en) * 2005-08-05 2007-02-08 Wei Zhu Devices for analyte assays and methods of use
WO2009026122A1 (en) * 2007-08-17 2009-02-26 Amgen Inc. Formulations of antibodies and fc-fusion molecules using polycations
CA2704056A1 (en) * 2007-10-29 2009-05-07 University Of Massachusetts Encapsulated nanoparticles for nucleic acid delivery
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
CA2746527A1 (en) 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Rna interference in skin indications
US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
EP2552478B1 (de) 2010-03-31 2016-12-21 Stabilitech Ltd. Hilfsstoffe zur stabilisierung von viralen partikeln
US10206960B2 (en) 2010-03-31 2019-02-19 Stabilitech Biopharma Ltd Stabilisation of viral particles
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
EP2598661B1 (de) 2010-07-26 2017-09-27 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in speichel- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
EP2603450B1 (de) 2010-08-14 2016-11-02 University of Massachusetts Wandpartikel aus hefezellen für rezeptorengerichtete nanopartikelfreisetzung
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
NO2616045T3 (de) 2010-09-15 2018-03-24
GB201117233D0 (en) * 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
EP3249054A1 (de) 2012-12-20 2017-11-29 Biomatrica, INC. Formulierungen und verfahren zur stabilisierung von pcr-reagenzien
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
IL285716B (en) 2014-05-07 2022-09-01 Applied Molecular Transp Llc Compacted molecules derived from colic toxin for oral delivery of biologically active cargo
JP6661554B2 (ja) 2014-06-10 2020-03-11 バイオマトリカ，インク． 周囲温度における血小板の安定化
JP2018521129A (ja) * 2015-07-07 2018-08-02 ナノビオ コーポレイションＮａｎｏｂｉｏ Ｃｏｒｐｏｒａｔｉｏｎ タンパク質の安定化のための方法および組成物
US11173197B2 (en) 2015-07-07 2021-11-16 Bluewillow Biologics, Inc. Methods and compositions for nanoemulsion vaccine formulations
WO2017100212A1 (en) 2015-12-08 2017-06-15 Biomatrica, Inc. Reduction of erythrocyte sedimentation rate
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
MX2020001525A (es) 2017-08-24 2020-03-20 Novo Nordisk As Composiciones de peptido similar al glucagon tipo 1 (glp-1) y sus usos.
CA3093386A1 (en) 2018-03-08 2019-09-12 Applied Molecular Transport Inc. Toxin-derived delivery constructs for oral delivery
HUE059330T2 (hu) 2018-03-08 2022-11-28 Applied Molecular Transport Inc Toxinból származó bejuttatási konstrukciók orális beadásra
AU2020331939A1 (en) 2019-08-16 2022-03-24 Applied Molecular Transport Inc. Compositions, formulations, and interleukin production and purification
GB202001501D0 (en) 2020-02-04 2020-03-18 Fabricnano Ltd Nucleic acid nanostructures
US20230093542A1 (en) 2020-02-18 2023-03-23 Novo Nordisk A/S Glp-1 compositions and uses thereof
GB202007428D0 (en) 2020-05-19 2020-07-01 Fabricnano Ltd Polynucleotide synthesis
GB202110595D0 (en) 2021-07-22 2021-09-08 Fabricnano Ltd Functionalised nucleic acid structure
CN115494232B (zh) * 2022-10-31 2023-10-27 江苏三联生物工程股份有限公司 4,4-二甲基噁唑啉在制备含辣根过氧化物酶的试剂中的应用

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GB8826429D0 (en) * 1988-11-11 1988-12-14 Univ Leeds Ind Service Ltd Enzyme stabilisation systems
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WO1992011844A1 (en) * 1991-01-03 1992-07-23 Alkermes Controlled Therapeutics, Inc. Stabilization of proteins by cationic biopolymers
US5356800A (en) * 1992-11-30 1994-10-18 Buckman Laboratories International, Inc. Stabilized liquid enzymatic compositions

Also Published As

Publication number Publication date
ATE290590T1 (de) 2005-03-15
DK0722492T3 (da) 2005-07-11
EP0722492B1 (de) 2005-03-09
WO1995010605A1 (en) 1995-04-20
US6133229A (en) 2000-10-17
GB9320782D0 (en) 1993-12-01
AU7817094A (en) 1995-05-04
DE69434290T2 (de) 2005-12-29
EP0722492A1 (de) 1996-07-24

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Legal Events

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