DK0720595T3 - Fremgangsmåde til adskillelse af to optiske antipoder ved krystallisation - Google Patents
Fremgangsmåde til adskillelse af to optiske antipoder ved krystallisationInfo
- Publication number
- DK0720595T3 DK0720595T3 DK94928427T DK94928427T DK0720595T3 DK 0720595 T3 DK0720595 T3 DK 0720595T3 DK 94928427 T DK94928427 T DK 94928427T DK 94928427 T DK94928427 T DK 94928427T DK 0720595 T3 DK0720595 T3 DK 0720595T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- enantiomer
- solution
- sec
- mother liquors
- Prior art date
Links
- 238000002425 crystallisation Methods 0.000 title abstract 3
- 230000008025 crystallization Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 239000010419 fine particle Substances 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/78—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by condensation or crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9311354A FR2710337B1 (fr) | 1993-09-23 | 1993-09-23 | Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé. |
| PCT/FR1994/001107 WO1995008522A1 (fr) | 1993-09-23 | 1994-09-22 | Procede de dedoublement de deux antipodes optiques par cristallisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0720595T3 true DK0720595T3 (da) | 1999-08-23 |
Family
ID=9451175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94928427T DK0720595T3 (da) | 1993-09-23 | 1994-09-22 | Fremgangsmåde til adskillelse af to optiske antipoder ved krystallisation |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6022409A (de) |
| EP (1) | EP0720595B1 (de) |
| JP (1) | JP3647862B2 (de) |
| AT (1) | ATE174889T1 (de) |
| DE (1) | DE69415545T2 (de) |
| DK (1) | DK0720595T3 (de) |
| ES (1) | ES2128584T3 (de) |
| FR (1) | FR2710337B1 (de) |
| WO (1) | WO1995008522A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0008563D0 (en) * | 2000-04-07 | 2000-05-24 | Cambridge Discovery Chemistry | Investigating different physical and/or chemical forms of materials |
| FR2849029B1 (fr) * | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
| US7368591B2 (en) | 2003-09-19 | 2008-05-06 | Cephalon France | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
| US7501514B1 (en) | 2003-10-15 | 2009-03-10 | Shire Biochem, Inc. | Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides |
| DE102005039501B4 (de) * | 2005-08-20 | 2013-09-12 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur Trennung verbindungsbildender chiraler Systeme |
| WO2008033431A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders |
| CN101583612A (zh) | 2006-09-15 | 2009-11-18 | 先灵公司 | 治疗脂质代谢障碍的氮杂环丁酮衍生物 |
| FR2909380B1 (fr) | 2006-12-04 | 2009-02-20 | Sidem Pharma Sa Sa | Conglomerats de sels de potassium de tenatoprazole |
| FR2920428B1 (fr) * | 2007-08-29 | 2012-06-15 | Univ Rouen | Procede de dedoublement de sels de l'omeprazole |
| DK2346890T3 (da) * | 2008-09-05 | 2013-06-24 | Shire Canada Inc | Separation af enantiomerer af 2,4-disubstituerede 1,3-oxathiolannucleosider |
| WO2010025968A2 (en) | 2008-09-05 | 2010-03-11 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Process for enantioseparation of chiral systems with compound formation using two subsequent crystallization steps |
| JP5536869B2 (ja) * | 2009-03-26 | 2014-07-02 | ポクセル・エスアーエス | 優先晶出法を利用したジヒドロ−１，３，５トリアジンラセミ体のエナンチオマー分離のための方法 |
| EP2292306B1 (de) * | 2009-09-02 | 2013-05-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum Trennen von racemischen verbindungsbildenden chiralen Substanzen durch ein zyklisches Kristallisationsverfahren und eine Kristallisationsvorrichtung |
| FR2954310B1 (fr) * | 2009-12-18 | 2014-07-25 | Univ Rouen | Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle |
| FR3054218B1 (fr) * | 2016-07-22 | 2020-03-06 | Universite De Rouen | Procede de dedoublement de sels de baclofene |
| CA3133002A1 (en) | 2019-03-20 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors |
| CN113727732B (zh) | 2019-03-20 | 2023-08-08 | 雷杰纳荣制药公司 | 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1456627A (fr) * | 1964-07-24 | 1966-07-08 | Asahi Chemical Ind | Perfectionnements aux procédés pour la résolution de l'acide glutamique racémique et de ses sels |
| GB1197809A (en) * | 1968-02-13 | 1970-07-08 | Inst Noguchi | Method for Continuous Optical Resolution of Organic Racemates. |
-
1993
- 1993-09-23 FR FR9311354A patent/FR2710337B1/fr not_active Expired - Lifetime
-
1994
- 1994-09-22 JP JP50960795A patent/JP3647862B2/ja not_active Expired - Lifetime
- 1994-09-22 DE DE69415545T patent/DE69415545T2/de not_active Expired - Lifetime
- 1994-09-22 DK DK94928427T patent/DK0720595T3/da active
- 1994-09-22 EP EP94928427A patent/EP0720595B1/de not_active Expired - Lifetime
- 1994-09-22 AT AT94928427T patent/ATE174889T1/de active
- 1994-09-22 WO PCT/FR1994/001107 patent/WO1995008522A1/fr active IP Right Grant
- 1994-09-22 US US08/619,477 patent/US6022409A/en not_active Expired - Lifetime
- 1994-09-22 ES ES94928427T patent/ES2128584T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0720595B1 (de) | 1998-12-23 |
| JP3647862B2 (ja) | 2005-05-18 |
| JPH09506861A (ja) | 1997-07-08 |
| FR2710337B1 (fr) | 1995-12-08 |
| WO1995008522A1 (fr) | 1995-03-30 |
| US6022409A (en) | 2000-02-08 |
| FR2710337A1 (fr) | 1995-03-31 |
| DE69415545T2 (de) | 1999-09-16 |
| ES2128584T3 (es) | 1999-05-16 |
| EP0720595A1 (de) | 1996-07-10 |
| ATE174889T1 (de) | 1999-01-15 |
| DE69415545D1 (de) | 1999-02-04 |
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