DE69415545D1 - Verfahren zur optischen spaltung von antipoden durch kristallisierung - Google Patents

Verfahren zur optischen spaltung von antipoden durch kristallisierung

Info

Publication number
DE69415545D1
DE69415545D1 DE69415545T DE69415545T DE69415545D1 DE 69415545 D1 DE69415545 D1 DE 69415545D1 DE 69415545 T DE69415545 T DE 69415545T DE 69415545 T DE69415545 T DE 69415545T DE 69415545 D1 DE69415545 D1 DE 69415545D1
Authority
DE
Germany
Prior art keywords
pct
enantiomer
solution
sec
mother liquors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69415545T
Other languages
English (en)
Other versions
DE69415545T2 (de
Inventor
Gerard Coquerel
Marie-Noelle Petit
Roger Bouaziz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Rouen
Original Assignee
Universite de Rouen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Rouen filed Critical Universite de Rouen
Publication of DE69415545D1 publication Critical patent/DE69415545D1/de
Application granted granted Critical
Publication of DE69415545T2 publication Critical patent/DE69415545T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00Separation of optically-active compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/78Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by condensation or crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/74Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69415545T 1993-09-23 1994-09-22 Verfahren zur optischen spaltung von antipoden durch kristallisierung Expired - Lifetime DE69415545T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9311354A FR2710337B1 (fr) 1993-09-23 1993-09-23 Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
PCT/FR1994/001107 WO1995008522A1 (fr) 1993-09-23 1994-09-22 Procede de dedoublement de deux antipodes optiques par cristallisation

Publications (2)

Publication Number Publication Date
DE69415545D1 true DE69415545D1 (de) 1999-02-04
DE69415545T2 DE69415545T2 (de) 1999-09-16

Family

ID=9451175

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415545T Expired - Lifetime DE69415545T2 (de) 1993-09-23 1994-09-22 Verfahren zur optischen spaltung von antipoden durch kristallisierung

Country Status (9)

Country Link
US (1) US6022409A (de)
EP (1) EP0720595B1 (de)
JP (1) JP3647862B2 (de)
AT (1) ATE174889T1 (de)
DE (1) DE69415545T2 (de)
DK (1) DK0720595T3 (de)
ES (1) ES2128584T3 (de)
FR (1) FR2710337B1 (de)
WO (1) WO1995008522A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0008563D0 (en) * 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7501514B1 (en) 2003-10-15 2009-03-10 Shire Biochem, Inc. Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides
DE102005039501B4 (de) 2005-08-20 2013-09-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur Trennung verbindungsbildender chiraler Systeme
JP2010503677A (ja) 2006-09-15 2010-02-04 シェーリング コーポレイション 脂質代謝の障害を治療するためのアゼチジノン誘導体
US20080070890A1 (en) * 2006-09-15 2008-03-20 Burnett Duane A Spirocyclic Azetidinone Compounds and Methods of Use Thereof
FR2909380B1 (fr) 2006-12-04 2009-02-20 Sidem Pharma Sa Sa Conglomerats de sels de potassium de tenatoprazole
FR2920428B1 (fr) * 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
ES2421708T3 (es) * 2008-09-05 2013-09-05 Shire Canada Inc Resolución enantiomérica de nucleósidos de 1,3-oxatiolano 2,4-disustituidos
WO2010025968A2 (en) 2008-09-05 2010-03-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. Process for enantioseparation of chiral systems with compound formation using two subsequent crystallization steps
WO2010109015A1 (en) 2009-03-26 2010-09-30 Poxel Process for enantiomeric separation of racemic dihydro-1,3,5 triazines via preferential crystallization
EP2292306B1 (de) * 2009-09-02 2013-05-01 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zum Trennen von racemischen verbindungsbildenden chiralen Substanzen durch ein zyklisches Kristallisationsverfahren und eine Kristallisationsvorrichtung
FR2954310B1 (fr) 2009-12-18 2014-07-25 Univ Rouen Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle
FR3054218B1 (fr) * 2016-07-22 2020-03-06 Universite De Rouen Procede de dedoublement de sels de baclofene
WO2020191163A1 (en) 2019-03-20 2020-09-24 Regeneron Pharmaceuticals, Inc. Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors
US11504390B2 (en) 2019-03-20 2022-11-22 Regeneron Pharmaceuticals, Inc. Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1456627A (fr) * 1964-07-24 1966-07-08 Asahi Chemical Ind Perfectionnements aux procédés pour la résolution de l'acide glutamique racémique et de ses sels
GB1197809A (en) * 1968-02-13 1970-07-08 Inst Noguchi Method for Continuous Optical Resolution of Organic Racemates.

Also Published As

Publication number Publication date
ES2128584T3 (es) 1999-05-16
WO1995008522A1 (fr) 1995-03-30
FR2710337A1 (fr) 1995-03-31
ATE174889T1 (de) 1999-01-15
EP0720595B1 (de) 1998-12-23
US6022409A (en) 2000-02-08
DK0720595T3 (da) 1999-08-23
JPH09506861A (ja) 1997-07-08
EP0720595A1 (de) 1996-07-10
FR2710337B1 (fr) 1995-12-08
JP3647862B2 (ja) 2005-05-18
DE69415545T2 (de) 1999-09-16

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