DK0719782T3 - Optisk aktive benzothiepinderivater samt fremstilling og anvendelse deraf - Google Patents

Optisk aktive benzothiepinderivater samt fremstilling og anvendelse deraf

Info

Publication number
DK0719782T3
DK0719782T3 DK95120444T DK95120444T DK0719782T3 DK 0719782 T3 DK0719782 T3 DK 0719782T3 DK 95120444 T DK95120444 T DK 95120444T DK 95120444 T DK95120444 T DK 95120444T DK 0719782 T3 DK0719782 T3 DK 0719782T3
Authority
DK
Denmark
Prior art keywords
preparation
optically active
active benzothiepine
benzothiepine derivatives
derivatives
Prior art date
Application number
DK95120444T
Other languages
Danish (da)
English (en)
Inventor
Takashi Sohda
Shigehisa Taketomi
Tsuneo Oda
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DK0719782T3 publication Critical patent/DK0719782T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655363Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
    • C07F9/655372Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/67Phosphorus compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DK95120444T 1994-12-28 1995-12-22 Optisk aktive benzothiepinderivater samt fremstilling og anvendelse deraf DK0719782T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32727594 1994-12-28

Publications (1)

Publication Number Publication Date
DK0719782T3 true DK0719782T3 (da) 2001-09-24

Family

ID=18197308

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95120444T DK0719782T3 (da) 1994-12-28 1995-12-22 Optisk aktive benzothiepinderivater samt fremstilling og anvendelse deraf

Country Status (20)

Country Link
US (2) US6346521B1 (zh)
EP (1) EP0719782B1 (zh)
KR (1) KR960022542A (zh)
CN (1) CN1058718C (zh)
AR (1) AR002018A1 (zh)
AT (1) ATE202782T1 (zh)
AU (1) AU689004B2 (zh)
BR (1) BR9506098A (zh)
CA (1) CA2166152A1 (zh)
DE (1) DE69521595T2 (zh)
DK (1) DK0719782T3 (zh)
ES (1) ES2158034T3 (zh)
FI (1) FI956273A (zh)
GR (1) GR3036757T3 (zh)
HU (1) HUT74562A (zh)
NO (1) NO303641B1 (zh)
NZ (1) NZ280745A (zh)
PT (1) PT719782E (zh)
RU (1) RU2162083C2 (zh)
TW (1) TW403757B (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910492A (en) * 1995-06-05 1999-06-08 Takeda Chemical Industries, Ltd. Osteogenic promoting pharmaceutical composition
WO1996039134A1 (en) * 1995-06-05 1996-12-12 Takeda Chemical Industries, Ltd. Osteogenetic promoting pharmaceutical composition
AU6471896A (en) * 1995-07-24 1997-02-18 Takeda Chemical Industries Ltd. Production of optically active benzothiepin salts
AU3868997A (en) * 1996-08-26 1998-03-19 Takeda Chemical Industries Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol
AU4571097A (en) * 1996-10-09 1998-05-05 Takeda Chemical Industries Ltd. A method for producing a microparticle
EP1087774A2 (en) * 1998-06-15 2001-04-04 Takeda Chemical Industries, Ltd. Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds
EP1103552A4 (en) 1998-08-07 2003-01-15 Takeda Chemical Industries Ltd BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
WO2000009100A2 (en) * 1998-08-12 2000-02-24 Takeda Chemical Industries, Ltd. Benzothiepine compounds as enhancer of cell differentiation induction factor
AU5998799A (en) * 1998-09-30 2000-04-17 Takeda Chemical Industries Ltd. Bone repair materials/artificial bone compositions
US6794544B2 (en) * 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
CA2454200A1 (en) * 2001-07-17 2003-01-30 Teva Pharmaceutical Industries Ltd. Dosage forms for immediate gastric release of a calcium transport stimulator coupled with delayed gastric release of a bis-phosphonate
US20050026871A1 (en) * 2002-07-17 2005-02-03 Moshe Flashner-Barak Method of increasing bioavailability of alendronate or other bis-phosphonate by predose administration of vitamin D derivative
EP1640010A1 (en) * 2003-07-01 2006-03-29 Astellas Pharma Inc. Agent inducing increase in bone mass
WO2009006226A1 (en) * 2007-06-29 2009-01-08 Kci Licensing Inc. Activation of bone and cartilage formation
EP2380878B1 (en) 2009-01-19 2013-08-14 Daiichi Sankyo Company, Limited Cyclic compound having hetero atom
KR20120006016A (ko) 2009-04-06 2012-01-17 다이이찌 산쿄 가부시키가이샤 치환 페닐기를 갖는 고리형 화합물
AU2011246067A1 (en) 2010-04-28 2012-09-27 Daiichi Sankyo Company, Limited [5,6] heterocyclic compound
WO2015030189A1 (ja) 2013-08-29 2015-03-05 京都薬品工業株式会社 新規芳香族化合物およびその用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158943A (en) * 1988-11-21 1992-10-27 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
DK656789A (da) * 1988-12-28 1990-06-29 Takeda Chemical Industries Ltd Benzoheterocykliske forbindelser
DK0460488T3 (da) * 1990-05-30 2001-09-17 Takeda Chemical Industries Ltd Svovlholdige heterocykliske forbindelser
JP3165866B2 (ja) * 1990-06-06 2001-05-14 武田薬品工業株式会社 含硫黄複素環化合物

Also Published As

Publication number Publication date
DE69521595T2 (de) 2002-05-23
PT719782E (pt) 2001-10-31
CA2166152A1 (en) 1996-06-29
CN1131669A (zh) 1996-09-25
NO955305D0 (no) 1995-12-27
RU2162083C2 (ru) 2001-01-20
EP0719782B1 (en) 2001-07-04
NZ280745A (en) 1997-09-22
FI956273A (fi) 1996-06-29
AU4069395A (en) 1996-07-04
ES2158034T3 (es) 2001-09-01
US6346521B1 (en) 2002-02-12
CN1058718C (zh) 2000-11-22
NO303641B1 (no) 1998-08-10
US6632807B1 (en) 2003-10-14
KR960022542A (ko) 1996-07-18
FI956273A0 (fi) 1995-12-27
GR3036757T3 (en) 2001-12-31
EP0719782A1 (en) 1996-07-03
BR9506098A (pt) 1997-12-23
AU689004B2 (en) 1998-03-19
HU9503802D0 (en) 1996-02-28
NO955305L (no) 1996-07-01
AR002018A1 (es) 1998-01-07
ATE202782T1 (de) 2001-07-15
DE69521595D1 (de) 2001-08-09
HUT74562A (en) 1997-01-28
TW403757B (en) 2000-09-01

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