DK0712838T3 - Acylphenylglycinderivat og forebyggende middel og lægemiddel til sygdomme, der er forårsaget af en forøget kollagenaseaktiv - Google Patents

Acylphenylglycinderivat og forebyggende middel og lægemiddel til sygdomme, der er forårsaget af en forøget kollagenaseaktiv

Info

Publication number
DK0712838T3
DK0712838T3 DK94923067T DK94923067T DK0712838T3 DK 0712838 T3 DK0712838 T3 DK 0712838T3 DK 94923067 T DK94923067 T DK 94923067T DK 94923067 T DK94923067 T DK 94923067T DK 0712838 T3 DK0712838 T3 DK 0712838T3
Authority
DK
Denmark
Prior art keywords
collagenase activity
diseases caused
preventative
drug
increased collagenase
Prior art date
Application number
DK94923067T
Other languages
Danish (da)
English (en)
Inventor
Ryoichi Hirayama
Takahiro Tsukida
Minoru Yamamoto
Shoji Ikeda
Fumio Sakamoto
Yuji Obata
Konomi Matsuo
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Application granted granted Critical
Publication of DK0712838T3 publication Critical patent/DK0712838T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK94923067T 1993-08-09 1994-08-03 Acylphenylglycinderivat og forebyggende middel og lægemiddel til sygdomme, der er forårsaget af en forøget kollagenaseaktiv DK0712838T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21812493 1993-08-09
PCT/JP1994/001284 WO1995004715A1 (fr) 1993-08-09 1994-08-03 Derive d'acylphenylglycine et agent preventif et curatif, concernant des maladies causees par une activite collagenase accrue, contenant un tel compose comme ingredient actif

Publications (1)

Publication Number Publication Date
DK0712838T3 true DK0712838T3 (da) 1999-07-19

Family

ID=16715014

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94923067T DK0712838T3 (da) 1993-08-09 1994-08-03 Acylphenylglycinderivat og forebyggende middel og lægemiddel til sygdomme, der er forårsaget af en forøget kollagenaseaktiv

Country Status (10)

Country Link
US (1) US5795891A (ja)
EP (1) EP0712838B1 (ja)
KR (1) KR100312097B1 (ja)
CN (1) CN1038583C (ja)
AT (1) ATE172959T1 (ja)
DE (1) DE69414396T2 (ja)
DK (1) DK0712838T3 (ja)
ES (1) ES2123808T3 (ja)
TW (1) TW280810B (ja)
WO (1) WO1995004715A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
US6127427A (en) 1995-11-23 2000-10-03 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
CN1060804C (zh) * 1997-03-17 2001-01-17 中国科学院微生物研究所 Iv型胶原酶特异性人源基因工程抗体
WO2001052891A1 (fr) * 2000-01-20 2001-07-26 Nippon Organon K. K. Inhibiteurs d'invasion plasmodiale dans des erythrocytes
US20210393632A1 (en) 2018-10-04 2021-12-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Egfr inhibitors for treating keratodermas
CN110554118A (zh) * 2019-10-15 2019-12-10 宁夏师范学院 一种检测尿液中萘酚含量的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
FR2609289B1 (fr) * 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes
AU2228292A (en) * 1991-06-14 1993-01-12 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor

Also Published As

Publication number Publication date
CN1133034A (zh) 1996-10-09
EP0712838A4 (en) 1996-03-19
DE69414396D1 (de) 1998-12-10
KR960703843A (ko) 1996-08-31
ATE172959T1 (de) 1998-11-15
KR100312097B1 (ko) 2002-11-13
WO1995004715A1 (fr) 1995-02-16
DE69414396T2 (de) 1999-07-15
CN1038583C (zh) 1998-06-03
TW280810B (ja) 1996-07-11
EP0712838B1 (en) 1998-11-04
US5795891A (en) 1998-08-18
ES2123808T3 (es) 1999-01-16
EP0712838A1 (en) 1996-05-22

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