DK0699686T3 - Biologisk aktive fragmenter af glukagon-lignende insulinotropisk peptid - Google Patents

Biologisk aktive fragmenter af glukagon-lignende insulinotropisk peptid

Info

Publication number
DK0699686T3
DK0699686T3 DK95305963T DK95305963T DK0699686T3 DK 0699686 T3 DK0699686 T3 DK 0699686T3 DK 95305963 T DK95305963 T DK 95305963T DK 95305963 T DK95305963 T DK 95305963T DK 0699686 T3 DK0699686 T3 DK 0699686T3
Authority
DK
Denmark
Prior art keywords
glucagon
insulinotropic peptide
biologically active
active fragments
polypeptides
Prior art date
Application number
DK95305963T
Other languages
Danish (da)
English (en)
Inventor
William Terry Johnson
Fatima Emitsela Yakubu-Madus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0699686T3 publication Critical patent/DK0699686T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK95305963T 1994-08-30 1995-08-25 Biologisk aktive fragmenter af glukagon-lignende insulinotropisk peptid DK0699686T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/297,731 US5574008A (en) 1994-08-30 1994-08-30 Biologically active fragments of glucagon-like insulinotropic peptide

Publications (1)

Publication Number Publication Date
DK0699686T3 true DK0699686T3 (da) 2004-02-16

Family

ID=23147523

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95305963T DK0699686T3 (da) 1994-08-30 1995-08-25 Biologisk aktive fragmenter af glukagon-lignende insulinotropisk peptid

Country Status (10)

Country Link
US (1) US5574008A (fr)
EP (1) EP0699686B1 (fr)
AT (1) ATE251642T1 (fr)
AU (1) AU3372595A (fr)
DE (1) DE69531889T2 (fr)
DK (1) DK0699686T3 (fr)
ES (1) ES2208666T3 (fr)
PT (1) PT699686E (fr)
SI (1) SI0699686T1 (fr)
WO (1) WO1996006628A1 (fr)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138486B2 (en) * 1986-05-05 2006-11-21 The General Hospital Corporation Insulinotropic hormone derivatives and uses thereof
US6849708B1 (en) 1986-05-05 2005-02-01 The General Hospital Corporation Insulinotropic hormone and uses thereof
US5614492A (en) * 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6284727B1 (en) 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
ES2319936T5 (es) * 1996-08-08 2013-06-24 Amylin Pharmaceuticals, Inc. Regulación de la motilidad gastrointestinal
WO1998030231A1 (fr) 1997-01-07 1998-07-16 Amylin Pharmaceuticals, Inc. Utilisation d'exendines et de leurs agonistes pour reduire la consommation alimentaire
US5846937A (en) * 1997-03-03 1998-12-08 1149336 Ontario Inc. Method of using exendin and GLP-1 to affect the central nervous system
US7157555B1 (en) * 1997-08-08 2007-01-02 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
EP1066314B1 (fr) 1997-11-14 2007-12-26 Amylin Pharmaceuticals, Inc. Nouveaux composes agonistes de l'exendine
US7223725B1 (en) 1997-11-14 2007-05-29 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
US6703359B1 (en) 1998-02-13 2004-03-09 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and GLP-1
KR100637433B1 (ko) * 2004-05-24 2006-10-20 삼성에스디아이 주식회사 발광 표시 장치
WO1999043705A1 (fr) * 1998-02-27 1999-09-02 Novo Nordisk A/S Derives de glp-1 tronques a l'extremite n-terminale
EP1306091A3 (fr) 1998-07-31 2003-05-21 Novo Nordisk A/S Stimulation de la prolifération des cellules de beta
US6720407B1 (en) * 1998-08-28 2004-04-13 Eli Lilly And Company Method for administering insulinotropic peptides
US6429197B1 (en) 1998-10-08 2002-08-06 Bionebraska, Inc. Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
US7259136B2 (en) * 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
WO2000034331A2 (fr) 1998-12-07 2000-06-15 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Analogues du glp-1
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US6444788B1 (en) 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
US6451987B1 (en) 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
ATE509028T1 (de) 1999-03-15 2011-05-15 Novo Nordisk As Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden
US6605648B1 (en) * 1999-04-06 2003-08-12 Phillips Plastics Corporation Sinterable structures and method
US6514500B1 (en) 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
WO2000069911A1 (fr) 1999-05-17 2000-11-23 Conjuchem, Inc. Peptides insulinotropes a longue duree d'action
US20090175821A1 (en) * 1999-05-17 2009-07-09 Bridon Dominique P Modified therapeutic peptides with extended half-lives in vivo
WO2001000654A2 (fr) 1999-06-29 2001-01-04 Pharmaceutical Discovery Corporation Purification et stabilisation de produits pharmaceutiques a base de peptides et de proteines
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6844321B2 (en) 2000-01-31 2005-01-18 Novo Nordisk A/S Crystallization of a GLP-1 analogue
WO2001066135A1 (fr) 2000-03-08 2001-09-13 Novo Nordisk A/S Reduction des lipides seriques
AU2001259063A1 (en) 2000-04-12 2001-10-30 Human Genome Sciences, Inc. Albumin fusion proteins
AU2002224124A1 (en) 2000-12-01 2002-06-11 Takeda Chemical Industries Ltd. Method for producing preparation containing bioactive substance
WO2002085406A1 (fr) * 2001-04-24 2002-10-31 Restoragen, Inc. Procedes et compositions pour le traitement d'etats lies a la resistance a l'insuline
AU2002317599B2 (en) * 2001-07-31 2008-04-03 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services GLP-1 exendin-4 peptide analogs and uses thereof
US6642003B2 (en) 2001-08-02 2003-11-04 Cedars-Sinai Medical Center Human glucose-dependent insulin-secreting cell line
WO2003059934A2 (fr) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Proteines de fusion d'albumine
EP1463751B1 (fr) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Proteines hybrides d'albumine
US7141240B2 (en) * 2002-03-12 2006-11-28 Cedars-Sinai Medical Center Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
DE60318938T2 (de) 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
US20080260838A1 (en) * 2003-08-01 2008-10-23 Mannkind Corporation Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
US20040209803A1 (en) * 2002-12-19 2004-10-21 Alain Baron Compositions for the treatment and prevention of nephropathy
US7790681B2 (en) * 2002-12-17 2010-09-07 Amylin Pharmaceuticals, Inc. Treatment of cardiac arrhythmias with GLP-1 receptor ligands
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
EP1594530A4 (fr) 2003-01-22 2006-10-11 Human Genome Sciences Inc Proteines hybrides d'albumine
EP1617888B1 (fr) 2003-04-23 2019-06-12 Valeritas, Inc. Pompe hydraulique d'administration de medicaments sur de longues durees
WO2005000222A2 (fr) 2003-05-30 2005-01-06 Amylin Pharmaceuticals, Inc. Nouveaux procedes et nouvelles compositions pour une administration amelioree par voie muqueuse de peptides et de proteines
EP1664108B1 (fr) 2003-08-21 2009-10-14 Novo Nordisk A/S Separation de polypeptides comprenant un acide amine racemise
WO2005021026A2 (fr) * 2003-08-29 2005-03-10 Amylin Pharmaceuticals, Inc. Procedes pour traiter ou ameliorer des maladies et des troubles associes a la ghreline
KR101243648B1 (ko) 2003-11-20 2013-03-14 노보 노르디스크 에이/에스 제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제
EP1694356B1 (fr) 2003-12-09 2011-02-16 Novo Nordisk A/S Regulation d'une preference alimentaire au moyen d'agonistes de glp-1
EP1701731A4 (fr) * 2003-12-12 2009-08-05 Einstein Coll Med Glp-1 (9-36): methodes et compositions
US20080194483A1 (en) * 2003-12-12 2008-08-14 Brownlee Michael A GLP-1 (9-36) methods and compositions
JP2007514752A (ja) 2003-12-16 2007-06-07 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Glp−1医薬組成物
JP2007536214A (ja) 2003-12-16 2007-12-13 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Glp−1類似体
EP1729795B1 (fr) * 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Proteines hybrides d'albumine
DE602005022239D1 (de) * 2004-04-23 2010-08-19 Conjuchem Biotechnologies Inc Festphase zur Verwendung in einem Verfahren zur Reinigung von Albuminkonjugaten
US20090069226A1 (en) * 2004-05-28 2009-03-12 Amylin Pharmaceuticals, Inc. Transmucosal delivery of peptides and proteins
WO2005120492A1 (fr) 2004-06-11 2005-12-22 Novo Nordisk A/S Remede contre l'obesite induite par les medicaments au moyen d'agonistes glp-1
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
EP1786784B1 (fr) 2004-08-20 2010-10-27 MannKind Corporation Catalyse de la synthese de dicetopiperazine
CA2578175C (fr) 2004-08-23 2014-10-14 Mannkind Corporation Sels de dicetopiperazine, sels de dicetomorpholine ou sels de dicetodioxane permettant l'administration de medicaments
DE102004043153B4 (de) * 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (fr) 2005-02-03 2006-08-10 Alza Corporation Solutions de solvant/polymere utilisees comme vehicules de suspension
US7803404B2 (en) 2005-09-14 2010-09-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
US8039432B2 (en) 2005-11-09 2011-10-18 Conjuchem, Llc Method of treatment of diabetes and/or obesity with reduced nausea side effect
WO2007064757A1 (fr) * 2005-11-29 2007-06-07 University Of Florida Research Foundation, Inc. Globuline antithymocytaire pour la prevention ou le retardement de l'apparition ou de la progression du diabete de type 1
EP2364735A3 (fr) 2005-12-16 2012-04-11 Nektar Therapeutics Conjugé de GLP-1 et de PEG ramafié
CN101379075B (zh) 2006-02-08 2013-05-15 隆萨股份公司 类胰高血糖素肽的合成
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
ES2566058T3 (es) 2006-03-30 2016-04-08 Valeritas, Inc. Dispositivo de suministro de fluidos de múltiples cartuchos
DE602007009377D1 (de) 2006-05-30 2010-11-04 Intarcia Therapeutics Inc Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem
US7682356B2 (en) 2006-08-09 2010-03-23 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies for use therein
JP5351884B2 (ja) 2007-04-23 2013-11-27 インターシア セラピューティクス,インコーポレイティド インスリン分泌促進性ペプチドの懸濁製剤及び使用
EP2185689A2 (fr) 2007-08-09 2010-05-19 Genzyme Corporation Procédé de traitement d'une maladie auto-immune avec des cellules souches mésenchymateuses
US8758761B2 (en) * 2007-09-30 2014-06-24 University Of Florida Research Foundation, Inc. Combination therapies for treating type 1 diabetes
JP5813323B2 (ja) * 2007-10-24 2015-11-17 マンカインド コーポレイション 活性薬剤の送達方法
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
CN101969927A (zh) * 2007-10-24 2011-02-09 曼金德公司 预防glp-1不良影响的方法
EP2231191A2 (fr) * 2007-12-11 2010-09-29 ConjuChem Biotechnologies Inc. Formulation de conjugués de peptides insulinotropes
CA2726861C (fr) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Dispositifs, formulations et methodes d'administration de plusieurs agents benefiques
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2570147B1 (fr) 2008-06-13 2017-10-18 MannKind Corporation Inhalateur de poudre sèche et système d'administration de médicament
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
WO2010054326A2 (fr) 2008-11-07 2010-05-14 The General Hospital Corporation Fragments c-terminaux du peptide 1 de type glucagon (glp-1)
EP2373391A1 (fr) 2008-12-08 2011-10-12 Novo Nordisk A/S Purification à contre-courant de polypeptides
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
KR20180079458A (ko) 2009-06-12 2018-07-10 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
HUE035862T2 (en) 2009-09-28 2018-05-28 Intarcia Therapeutics Inc Rapid development and / or completion of substantially steady-state drug delivery
EP2496295A1 (fr) 2009-11-03 2012-09-12 MannKind Corporation Appareil et méthode de simulation d'efforts d'inhalation
CA2782056C (fr) 2009-11-25 2021-03-09 Arisgen Sa Administration de peptides par voie muqueuse
EP2555791B1 (fr) 2010-04-09 2017-11-01 Sinai Health System Méthodes de traitement de troubles du tractus gastro-intestinal au moyen d'un agoniste glp-1
CA2797033C (fr) 2010-04-22 2021-10-19 Longevity Biotech, Inc. Polypeptides tres actifs et procedes pour les preparer et les utiliser
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
EP2588490B1 (fr) 2010-07-02 2017-02-22 Angiochem Inc. Polypeptides courts contenant des acides aminés d pour conjugués thérapeutiques et leurs utilisations
WO2012054822A1 (fr) 2010-10-22 2012-04-26 Nektar Therapeutics Conjugués polymère-glp 1 pharmacologiquement actifs
WO2012054861A1 (fr) 2010-10-22 2012-04-26 Nektar Therapeutics Conjugués glp-1-polymère ayant une liaison pouvant être rompue
WO2012061466A2 (fr) 2010-11-02 2012-05-10 The General Hospital Corporation Méthodes de traitement d'une maladie de stéatose
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
WO2013006692A2 (fr) 2011-07-06 2013-01-10 The General Hospital Corporation Méthodes de traitement utilisant un pentapeptide dérivé de l'extrémité c-terminale du glp-1 (glucagon-like peptide 1)
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
CN104582736A (zh) 2012-06-21 2015-04-29 印第安纳大学研究及科技有限公司 Fc效应子功能改变的肠降血糖素受体配体多肽Fc区融合多肽和缀合物
JP6224586B2 (ja) 2012-07-10 2017-11-01 武田薬品工業株式会社 注射用製剤
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
CA2906817C (fr) 2013-03-15 2022-01-18 Mannkind Corporation Compositions de dicetopiperazine microcristallines et procedes
US9789164B2 (en) 2013-03-15 2017-10-17 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
CN106029087A (zh) 2013-12-20 2016-10-12 印第安纳大学研究及科技有限公司 脂质化肠降血糖素受体配体人免疫球蛋白fc区融合多肽
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
CN104267194B (zh) * 2014-09-23 2016-01-13 上海市东方医院 人胰高血糖素样肽-1、抗体及其试剂盒
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
ES2968262T3 (es) 2015-06-03 2024-05-08 I2O Therapeutics Inc Sistemas de colocación de implantes
WO2017200943A1 (fr) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Polypeptides sélectifs du récepteur du glucagon et méthodes pour les employer
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
HRP20240485T1 (hr) 2017-08-24 2024-07-05 Novo Nordisk A/S Pripravci glp-1 i njihova upotreba
WO2020077129A1 (fr) 2018-10-11 2020-04-16 Intarcia Therapeutics, Inc. Polypeptides analogues d'amyline humaine et procédés d'utilisation
US20230082544A1 (en) 2020-02-18 2023-03-16 Novo Nordisk A/S Pharmaceutical formulations
CA3223596A1 (fr) * 2021-06-29 2023-01-05 Thomas A. GILL Peptides pour reguler le glucose

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202757A (en) * 1981-12-23 1985-11-08 Novo Industri As Peptides and medicaments
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
US5118666A (en) * 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US5120712A (en) * 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
JP2583257B2 (ja) * 1986-05-05 1997-02-19 ザ・ジェネラル・ホスピタル・コーポレーション インシュリン向性ホルモン
US4923967A (en) 1988-09-26 1990-05-08 Eli Lilly And Company Purification and refolding of recombinant proteins
JPH04504246A (ja) * 1989-03-20 1992-07-30 ザ・ジェネラル・ホスピタル・コーポレーション インシュリン刺激ホルモン
ATE164852T1 (de) * 1990-01-24 1998-04-15 Douglas I Buckley Glp-1-analoga verwendbar in der diabetesbehandlung
DK36392D0 (da) * 1992-03-19 1992-03-19 Novo Nordisk As Anvendelse af kemisk forbindelse
JP2575298B2 (ja) * 1992-06-15 1997-01-22 フアイザー・インコーポレイテツド グルカゴン様ペプチド及びインシュリノトロピン誘導体
NZ250844A (en) * 1993-04-07 1996-03-26 Pfizer Treatment of non-insulin dependant diabetes with peptides; composition
US5512549A (en) * 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use

Also Published As

Publication number Publication date
DE69531889D1 (de) 2003-11-13
PT699686E (pt) 2004-02-27
ES2208666T3 (es) 2004-06-16
EP0699686B1 (fr) 2003-10-08
AU3372595A (en) 1996-03-22
EP0699686A2 (fr) 1996-03-06
EP0699686A3 (fr) 1996-10-16
WO1996006628A1 (fr) 1996-03-07
SI0699686T1 (en) 2004-02-29
DE69531889T2 (de) 2004-07-22
US5574008A (en) 1996-11-12
ATE251642T1 (de) 2003-10-15

Similar Documents

Publication Publication Date Title
DK0699686T3 (da) Biologisk aktive fragmenter af glukagon-lignende insulinotropisk peptid
CO4480109A1 (es) Analogos, composiciones y procedimientos de uso de peptidos insulinotropicos similares al glucagon
ATE193541T1 (de) Insulinotropes hormon
ATE164852T1 (de) Glp-1-analoga verwendbar in der diabetesbehandlung
GEP20063908B (en) Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
ATE480259T1 (de) Intranasale verabreichung von glucose- regulierenden peptiden
DE60228972D1 (de) Glp 1 exendin 4 peptidanaloga und deren verwendungen
DK1171465T3 (da) Analoger til gastroinhibitorisk peptid og deres anvendelse til behandling af diabetes
UY27893A1 (es) Agonistas del receptor (vpac2) del peptido activante de la adenilatociclasa hipofisaria (pacap) y sus metodos de uso farmacologicos
PE20011363A1 (es) Analogos del peptido-1 semejante a glucagon
WO2004094461A3 (fr) Mimetiques du peptide 1 de type glucagon humain utilises dans le traitement du diabete et des pathologies apparentees
DK0470117T3 (da) Anvendelse af "calcitonin gene-related peptides" til fremstilling af lægemidler til behandling af erektile dysfunktioner
DK0523330T3 (da) Implanterbare sammensætninger indeholdende et biologisk aktivt protein, peptid eller polypeptid
ECSP951557A (es) Analogos composiciones y procedimientos de uso de peptidos insulinotropicos similares al glucagon
ECSP993116A (es) Procedimiento para administrar peptidos insulinotropicos
AR005791A1 (es) Proteina de hormona del crecimiento humano mutante; desoxirribo-nucleotido que la codifica; peptido de dicha proteina; plasmido de expresion deldesoxirribonucleotido; producto generado por las celulas transformadas por el anterior; anticuerpo y medicamento que contiene la proteina o el