DK0695361T4 - Ekspression af heterologe gener ifølge en målekspressionsprofil - Google Patents

Ekspression af heterologe gener ifølge en målekspressionsprofil

Info

Publication number
DK0695361T4
DK0695361T4 DK94913175.9T DK94913175T DK0695361T4 DK 0695361 T4 DK0695361 T4 DK 0695361T4 DK 94913175 T DK94913175 T DK 94913175T DK 0695361 T4 DK0695361 T4 DK 0695361T4
Authority
DK
Denmark
Prior art keywords
expression
heterologous genes
genes according
target
profile
Prior art date
Application number
DK94913175.9T
Other languages
English (en)
Other versions
DK0695361T3 (da
Inventor
Austin Gerard Smith
Peter Scott Mountford
Richard Frank Lathe
Original Assignee
Univ Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27266666&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0695361(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB939308271A external-priority patent/GB9308271D0/en
Priority claimed from GB939313323A external-priority patent/GB9313323D0/en
Priority claimed from GB9401011A external-priority patent/GB9401011D0/en
Application filed by Univ Edinburgh filed Critical Univ Edinburgh
Publication of DK0695361T3 publication Critical patent/DK0695361T3/da
Application granted granted Critical
Publication of DK0695361T4 publication Critical patent/DK0695361T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/60—Vectors containing traps for, e.g. exons, promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Lubricants (AREA)
DK94913175.9T 1993-04-21 1994-04-21 Ekspression af heterologe gener ifølge en målekspressionsprofil DK0695361T4 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939308271A GB9308271D0 (en) 1993-04-21 1993-04-21 Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
GB939313323A GB9313323D0 (en) 1993-06-28 1993-06-28 Expression of heterologous genes
GB9401011A GB9401011D0 (en) 1994-01-20 1994-01-20 Expression of heterologous genes
PCT/GB1994/000849 WO1994024301A1 (en) 1993-04-21 1994-04-21 Expression of heterologous genes according to a targeted expression profile

Publications (2)

Publication Number Publication Date
DK0695361T3 DK0695361T3 (da) 2003-10-27
DK0695361T4 true DK0695361T4 (da) 2010-03-22

Family

ID=27266666

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94913175.9T DK0695361T4 (da) 1993-04-21 1994-04-21 Ekspression af heterologe gener ifølge en målekspressionsprofil

Country Status (12)

Country Link
US (3) US6150169A (da)
EP (2) EP1403376A3 (da)
JP (3) JP4375759B2 (da)
AT (1) ATE247171T1 (da)
AU (1) AU678234B2 (da)
CA (1) CA2161088A1 (da)
DE (1) DE69433034T3 (da)
DK (1) DK0695361T4 (da)
IL (1) IL109382A (da)
NZ (1) NZ265091A (da)
SG (1) SG48698A1 (da)
WO (1) WO1994024301A1 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ265091A (en) 1993-04-21 1997-07-27 Univ Edinburgh Dna constructs for inserting heterologous gene sequences into a host genome
DE19514310A1 (de) * 1995-04-18 1996-10-24 Univ Ludwigs Albert Vektoren zur Transfektion von eukaryotischen Zellen, deren Verwendung und damit transfizierte Zielzellen
GB9524973D0 (en) * 1995-12-06 1996-02-07 Lynxvale Ltd Viral vectors
US5928888A (en) * 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
US7332338B2 (en) 1996-10-04 2008-02-19 Lexicon Pharmaceuticals, Inc. Vectors for making genomic modifications
JP2001507577A (ja) * 1996-12-31 2001-06-12 ジョージ エイ ガイタナリス 哺乳動物の遺伝子に変異を導入するためのベクターおよび方法
US6245564B1 (en) 1997-01-23 2001-06-12 Cornell Research Foundation, Inc. Method for separating cells
WO1999028449A2 (en) * 1997-11-28 1999-06-10 Medical Research Council Yac vectors
US6808921B1 (en) 1998-03-27 2004-10-26 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
US6436707B1 (en) * 1998-03-27 2002-08-20 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
JP2002511257A (ja) * 1998-04-14 2002-04-16 カイロン コーポレイション 目的の遺伝子を発現するための非クローニング技術
GB9819912D0 (en) 1998-09-11 1998-11-04 Univ Edinburgh Propagation and/or derivation of embryonic stem cells
US7531715B1 (en) 1999-01-13 2009-05-12 Ppl Therapeutics (Scotland) Double nuclear transfer method and results thereof
US20050060101A1 (en) * 1999-06-28 2005-03-17 Bevilacqua Michael P. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US20040225449A1 (en) * 1999-06-28 2004-11-11 Bevilacqua Michael P. Systems and methods for characterizing a biological condition or agent using selected gene expression profiles
US6960439B2 (en) * 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US20060115826A1 (en) * 1999-06-28 2006-06-01 Michael Bevilacqua Gene expression profiling for identification monitoring and treatment of multiple sclerosis
EP1370132A2 (en) 2001-03-21 2003-12-17 Geron Corporation Use of telomerase reverse transcriptase to create homozygous knockout animals
CA2449303C (en) * 2001-06-06 2014-10-14 Regeneron Pharmaceuticals, Inc. Method for targeting transcriptionally active loci
US7473557B2 (en) * 2001-06-06 2009-01-06 Regeneron Pharmaceuticals, Inc. Method for targeting transcriptionally active loci
CA2466502A1 (en) * 2001-11-09 2003-05-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
EP1452093A4 (en) * 2001-11-15 2007-08-15 Kirin Brewery CHIMERIC ANIMALS
US20030157641A1 (en) * 2001-11-16 2003-08-21 Idec Pharmaceuticals Corporation Polycistronic expression of antibodies
JP5424871B2 (ja) * 2006-05-19 2014-02-26 グライコフィ， インコーポレイテッド 組換えベクター
JP5322924B2 (ja) 2006-06-01 2013-10-23 フェレニギング フォール クリステリューク ホーゲル オンデルウィース ウェテンシャッペリューク オンデルツォイク エン パティエンテンツォーク 細胞ｐＨに関連する植物核酸およびその使用
US20110198764A1 (en) * 2010-02-18 2011-08-18 Tekni-Plex, Inc. Aeration system with antimicrobial properties
EP2383339A1 (en) * 2010-04-27 2011-11-02 Harald Von Melchner Gene trapping for use in gene therapy
WO2013089123A1 (ja) * 2011-12-13 2013-06-20 公立大学法人横浜市立大学 遺伝子ターゲティングベクター及びその利用方法
WO2013158309A2 (en) * 2012-04-18 2013-10-24 The Board Of Trustees Of The Leland Stanford Junior University Non-disruptive gene targeting
CN106460009A (zh) 2014-03-21 2017-02-22 小利兰·斯坦福大学托管委员会 无核酸酶的基因组编辑
US20190284582A1 (en) 2016-11-03 2019-09-19 Temple University-Of The Commonwealth System Of Higher Education DNA Plasmids for the Fast Generation of Homologous Recombination Vectors for Cell Line Development
JP7460643B2 (ja) 2018-10-16 2024-04-02 ブルーアレル， エルエルシー 遺伝子へのｄｎａの標的化挿入のための方法
EP4281034A1 (en) 2021-01-24 2023-11-29 Forrest, Michael, David Inhibitors of atp synthase - cosmetic and therapeutic uses

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FR2646438B1 (fr) * 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
CA2045175C (en) * 1989-11-06 2003-03-18 Arthur I. Skoultchi Production of proteins using homologous recombination
EP0539573A4 (en) * 1991-05-15 1993-12-29 Cell Genesys, Inc. Genomic modifications with homologous dna targeting
WO1993007266A1 (en) * 1991-10-07 1993-04-15 Idaho Research Foundation, Inc. Genetic construct for selection of homologous recombinants on a single selective medium
PT101031B (pt) * 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
NZ265091A (en) 1993-04-21 1997-07-27 Univ Edinburgh Dna constructs for inserting heterologous gene sequences into a host genome
US6248934B1 (en) * 1998-10-26 2001-06-19 The Regents Of The University Of California Gene trap vectors

Also Published As

Publication number Publication date
EP1403376A3 (en) 2007-08-29
AU678234B2 (en) 1997-05-22
DE69433034D1 (de) 2003-09-18
JP4375759B2 (ja) 2009-12-02
IL109382A (en) 2005-08-31
US6150169A (en) 2000-11-21
US7005299B1 (en) 2006-02-28
NZ265091A (en) 1997-07-27
JP2009017889A (ja) 2009-01-29
ATE247171T1 (de) 2003-08-15
EP0695361B2 (en) 2009-11-11
IL109382A0 (en) 1994-07-31
DE69433034T2 (de) 2004-06-09
DE69433034T3 (de) 2010-04-15
AU6542794A (en) 1994-11-08
JPH09500005A (ja) 1997-01-07
CA2161088A1 (en) 1994-10-27
EP0695361B1 (en) 2003-08-13
EP0695361A1 (en) 1996-02-07
DK0695361T3 (da) 2003-10-27
JP2007306942A (ja) 2007-11-29
WO1994024301A1 (en) 1994-10-27
SG48698A1 (en) 1998-05-18
US20090241207A1 (en) 2009-09-24
EP1403376A2 (en) 2004-03-31

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