DK0655065T3 - - Google Patents

Info

Publication number
DK0655065T3
DK0655065T3 DK93919994.9T DK93919994T DK0655065T3 DK 0655065 T3 DK0655065 T3 DK 0655065T3 DK 93919994 T DK93919994 T DK 93919994T DK 0655065 T3 DK0655065 T3 DK 0655065T3
Authority
DK
Denmark
Prior art keywords
hydroxyrapamycin
formula
compound
deoxo
immunosuppressive
Prior art date
Application number
DK93919994.9T
Other languages
Danish (da)
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0655065T3 publication Critical patent/DK0655065T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK93919994.9T 1992-08-13 1993-08-12 DK0655065T3 (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
DK0655065T3 true DK0655065T3 (xx) 1997-02-24

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93919994.9T DK0655065T3 (xx) 1992-08-13 1993-08-12

Country Status (12)

Country Link
EP (1) EP0655065B1 (xx)
JP (1) JPH08501084A (xx)
AT (1) ATE146179T1 (xx)
AU (1) AU5007193A (xx)
CA (1) CA2142288A1 (xx)
DE (1) DE69306585T2 (xx)
DK (1) DK0655065T3 (xx)
ES (1) ES2096941T3 (xx)
GR (1) GR3022730T3 (xx)
HU (1) HU221499B (xx)
MX (1) MX9304868A (xx)
WO (1) WO1994004540A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
NZ311647A (en) 1995-06-09 1999-11-29 Novartis Ag Rapamycin derivatives
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EP1212331B1 (en) 1999-08-24 2004-04-21 Ariad Gene Therapeutics, Inc. 28-epirapalogs
PL216224B1 (pl) 2002-02-01 2014-03-31 Ariad Pharmaceuticals Pochodne rapamycyny zawierające fosfor, kompozycja je zawierająca oraz ich zastosowanie
EP1594459B1 (en) 2002-12-30 2010-02-17 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN101583347A (zh) 2006-11-14 2009-11-18 阿里亚德医药股份有限公司 口服制剂
WO2009089549A1 (en) 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
US9593356B2 (en) 2013-06-11 2017-03-14 Takara Bio Usa, Inc. Protein enriched microvesicles and methods of making and using the same
AU2019262979B2 (en) 2018-05-01 2023-07-06 Revolution Medicines, Inc. C26-linked rapamycin analogs as mTOR inhibitors
WO2022216900A2 (en) * 2021-04-09 2022-10-13 Revolution Medicines, Inc. Synthesis of rapamycin analog compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
GR3022730T3 (en) 1997-06-30
HU9500432D0 (en) 1995-04-28
EP0655065A1 (en) 1995-05-31
AU5007193A (en) 1994-03-15
DE69306585D1 (de) 1997-01-23
HUT71614A (en) 1996-01-29
ES2096941T3 (es) 1997-03-16
MX9304868A (es) 1994-05-31
WO1994004540A1 (en) 1994-03-03
DE69306585T2 (de) 1997-04-17
EP0655065B1 (en) 1996-12-11
CA2142288A1 (en) 1994-03-03
HU221499B (en) 2002-10-28
JPH08501084A (ja) 1996-02-06
ATE146179T1 (de) 1996-12-15

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