DK0649405T3 - 22-en-25-oxa-derivater i D-vitaminserien, fremgangsmåde til fremstilling heraf, farmaceutiske præparater indeholdende disse derivater samt anvendelse af sådanne præparater som lægemidler. - Google Patents
22-en-25-oxa-derivater i D-vitaminserien, fremgangsmåde til fremstilling heraf, farmaceutiske præparater indeholdende disse derivater samt anvendelse af sådanne præparater som lægemidler.Info
- Publication number
- DK0649405T3 DK0649405T3 DK93915800.2T DK93915800T DK0649405T3 DK 0649405 T3 DK0649405 T3 DK 0649405T3 DK 93915800 T DK93915800 T DK 93915800T DK 0649405 T3 DK0649405 T3 DK 0649405T3
- Authority
- DK
- Denmark
- Prior art keywords
- derivatives
- pct
- vitamin
- series
- oxa
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 235000019166 vitamin D Nutrition 0.000 title abstract 2
- 239000011710 vitamin D Substances 0.000 title abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
- 229940046008 vitamin d Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 2
- 239000003814 drug Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4221961A DE4221961A1 (de) | 1992-06-30 | 1992-06-30 | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0649405T3 true DK0649405T3 (da) | 1997-09-29 |
Family
ID=6462459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93915800.2T DK0649405T3 (da) | 1992-06-30 | 1993-06-30 | 22-en-25-oxa-derivater i D-vitaminserien, fremgangsmåde til fremstilling heraf, farmaceutiske præparater indeholdende disse derivater samt anvendelse af sådanne præparater som lægemidler. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5663157A (ja) |
| EP (1) | EP0649405B1 (ja) |
| JP (1) | JP3589664B2 (ja) |
| AT (1) | ATE150745T1 (ja) |
| DE (2) | DE4221961A1 (ja) |
| DK (1) | DK0649405T3 (ja) |
| ES (1) | ES2102043T3 (ja) |
| GR (1) | GR3023437T3 (ja) |
| WO (1) | WO1994000429A1 (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| DE19744127B4 (de) * | 1997-10-01 | 2006-10-05 | Schering Ag | Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln |
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| AU4510001A (en) * | 1999-12-02 | 2001-06-18 | Penn State Research Foundation, The | Treatment of inflammatory bowel disease with vitamin d compounds |
| US6358939B1 (en) * | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US6989377B2 (en) * | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| WO2002006218A2 (en) * | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
| US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| EP2393494A1 (en) | 2009-01-27 | 2011-12-14 | Berg Biosystems, LLC | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| CA2770683C (en) | 2009-08-14 | 2018-09-04 | Berg Biosystems, Llc | Vitamin d3 and analogs thereof for treating alopecia |
| SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2114570B (en) * | 1981-11-02 | 1985-08-07 | Res Inst Medicine Chem | Chemical compounds |
| US4594432A (en) * | 1983-01-28 | 1986-06-10 | Hoffman-La Roche Inc. | Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol |
| US4719205A (en) * | 1984-01-30 | 1988-01-12 | Wisconsin Alumini Research Foundation | Side-chain unsaturated 1-hydroxyvitamin D compounds |
| JPS6144860A (ja) * | 1984-08-10 | 1986-03-04 | Taisho Pharmaceut Co Ltd | １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３ |
| JPS6172652A (ja) * | 1984-09-14 | 1986-04-14 | Asahi Glass Co Ltd | 歯科材料用リン酸カルシウム系結晶性ガラス |
| US4612308A (en) * | 1984-11-29 | 1986-09-16 | Hoffmann-La Roche Inc. | 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers |
| EP0205285B1 (en) * | 1985-05-30 | 1989-08-09 | Taisho Pharmaceutical Co. Ltd | Vitamin d3 derivatives |
| EP0245524B1 (en) * | 1985-11-21 | 1991-04-17 | Taisho Pharmaceutical Co. Ltd | Vitamin d 3 derivative |
| JPH0764804B2 (ja) * | 1986-04-25 | 1995-07-12 | 住友製薬株式会社 | 活性型ビタミンｄ３のフッ素誘導体 |
| US4853378A (en) * | 1986-10-20 | 1989-08-01 | Sumitomo Chemical Company, Limited | Fluorine derivatives of vitamin D3 and process for producing the same |
| DE3865544D1 (de) * | 1987-06-23 | 1991-11-21 | Yamanouchi Pharma Co Ltd | Vitamin d3-derivate. |
| US5087619A (en) * | 1988-01-20 | 1992-02-11 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| US5145846A (en) * | 1988-01-20 | 1992-09-08 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| US5206229A (en) * | 1988-04-21 | 1993-04-27 | Leo Pharmaceutical Products Ltd | Vitamin d analogues |
| AU629831B2 (en) * | 1988-04-29 | 1992-10-15 | Wisconsin Alumni Research Foundation | Side chain unsaturated 1 alpha-hydroxyvitamin d homologs for the treatment of leukemia |
| US4927815A (en) * | 1988-04-29 | 1990-05-22 | Wisconsin Alumni Research Foundation | Compounds effective in inducing cell differentiation and process for preparing same |
| US4851401A (en) * | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
| US5401732A (en) * | 1989-02-23 | 1995-03-28 | Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab | Vitamin D analogues |
| US5401731A (en) * | 1989-06-29 | 1995-03-28 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) | Vitamin D analogues |
| GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
| ATE106391T1 (de) * | 1990-02-06 | 1994-06-15 | Schering Ag | Seitenketten-homologe vitamin-d-derivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische präparate, sowie deren verwendung als arzneimittel. |
| US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
| DE4011682A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | 24-oxa-derivate in der vitamin d-reihe |
| US5206230A (en) * | 1991-06-05 | 1993-04-27 | Daikin Industries, Ltd. | Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same |
| US5278155A (en) * | 1991-06-05 | 1994-01-11 | Daikin Industries, Ltd. | Fluorine-containing vitamin D3 analogues and cell differentiation-inducing agent containing the same |
| US5210237A (en) * | 1991-08-27 | 1993-05-11 | Daikin Industries, Ltd. | Vitamin d3 analogues |
| US5200536A (en) * | 1992-02-10 | 1993-04-06 | Daikin Industries Ltd. | Fluorine-containing vitamin D3 analogues |
| US5194431A (en) * | 1992-07-08 | 1993-03-16 | Wisconsin Alumni Research Foundation | 24-cyclopropane vitamin D derivatives |
-
1992
- 1992-06-30 DE DE4221961A patent/DE4221961A1/de not_active Withdrawn
-
1993
- 1993-06-30 DE DE59305972T patent/DE59305972D1/de not_active Expired - Lifetime
- 1993-06-30 EP EP93915800A patent/EP0649405B1/de not_active Expired - Lifetime
- 1993-06-30 JP JP50206494A patent/JP3589664B2/ja not_active Expired - Fee Related
- 1993-06-30 WO PCT/EP1993/001735 patent/WO1994000429A1/de active IP Right Grant
- 1993-06-30 US US08/362,438 patent/US5663157A/en not_active Expired - Fee Related
- 1993-06-30 DK DK93915800.2T patent/DK0649405T3/da active
- 1993-06-30 ES ES93915800T patent/ES2102043T3/es not_active Expired - Lifetime
- 1993-06-30 AT AT93915800T patent/ATE150745T1/de not_active IP Right Cessation
-
1997
- 1997-05-15 GR GR970401086T patent/GR3023437T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0649405B1 (de) | 1997-03-26 |
| GR3023437T3 (en) | 1997-08-29 |
| ES2102043T3 (es) | 1997-07-16 |
| EP0649405A1 (de) | 1995-04-26 |
| US5663157A (en) | 1997-09-02 |
| ATE150745T1 (de) | 1997-04-15 |
| JPH07508515A (ja) | 1995-09-21 |
| WO1994000429A1 (de) | 1994-01-06 |
| DE59305972D1 (de) | 1997-04-30 |
| JP3589664B2 (ja) | 2004-11-17 |
| DE4221961A1 (de) | 1994-01-05 |
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