DK0638121T3 - Målrettet spaltning af RNA under anvendelse af eukaryotisk ribonuklease P og ekstern ledersekvens - Google Patents
Målrettet spaltning af RNA under anvendelse af eukaryotisk ribonuklease P og ekstern ledersekvensInfo
- Publication number
- DK0638121T3 DK0638121T3 DK93910848.6T DK93910848T DK0638121T3 DK 0638121 T3 DK0638121 T3 DK 0638121T3 DK 93910848 T DK93910848 T DK 93910848T DK 0638121 T3 DK0638121 T3 DK 0638121T3
- Authority
- DK
- Denmark
- Prior art keywords
- egs
- rna
- rnaase
- cleavage
- loop
- Prior art date
Links
- 238000003776 cleavage reaction Methods 0.000 title abstract 5
- 230000007017 scission Effects 0.000 title abstract 5
- 102000004167 Ribonuclease P Human genes 0.000 title 1
- 108090000621 Ribonuclease P Proteins 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 6
- 108020005098 Anticodon Proteins 0.000 abstract 3
- 108020004566 Transfer RNA Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108091027075 5S-rRNA precursor Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/126—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes involving RNAse P
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87509992A | 1992-04-28 | 1992-04-28 | |
| US93193792A | 1992-08-18 | 1992-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0638121T3 true DK0638121T3 (da) | 1996-08-12 |
Family
ID=27128368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93910848.6T DK0638121T3 (da) | 1992-04-28 | 1993-04-28 | Målrettet spaltning af RNA under anvendelse af eukaryotisk ribonuklease P og ekstern ledersekvens |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0638121B1 (da) |
| JP (1) | JP3015463B2 (da) |
| AT (1) | ATE140482T1 (da) |
| AU (1) | AU669367B2 (da) |
| CA (1) | CA2117903C (da) |
| DE (1) | DE69303712T2 (da) |
| DK (1) | DK0638121T3 (da) |
| ES (1) | ES2093427T3 (da) |
| GR (1) | GR3020859T3 (da) |
| WO (1) | WO1993022434A2 (da) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
| US5683873A (en) * | 1995-01-13 | 1997-11-04 | Innovir Laboratories, Inc. | EGS-mediated inactivation of target RNA |
| US6057153A (en) * | 1995-01-13 | 2000-05-02 | Yale University | Stabilized external guide sequences |
| US5877162A (en) * | 1996-03-14 | 1999-03-02 | Innovir Laboratories, Inc. | Short external guide sequences |
| US6610478B1 (en) | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
| EP1032707A2 (en) * | 1997-11-21 | 2000-09-06 | Yale University | Method for identifying and inhibiting functional nucleic acid molecules in cells |
| US6013447A (en) * | 1997-11-21 | 2000-01-11 | Innovir Laboratories, Inc. | Random intracellular method for obtaining optimally active nucleic acid molecules |
| US6248525B1 (en) | 1998-03-30 | 2001-06-19 | Yale University | Method for identifying essential or functional genes |
| EP1326892A2 (en) | 2000-10-12 | 2003-07-16 | University of Rochester | Compositions that inhibit proliferation of cancer cells |
| MXPA04007586A (es) | 2002-02-06 | 2005-06-08 | Vicor Technologies Inc | Moleculas anti-infarto. |
| US20050287648A1 (en) | 2002-08-05 | 2005-12-29 | University Of Rochester | Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof |
| US9233120B2 (en) | 2002-11-15 | 2016-01-12 | Jyant Technologies | Anti-CCL25 and anti-CCR9 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US8658377B2 (en) | 2002-11-15 | 2014-02-25 | Morehouse School Of Medicine | Detecting cancer with anti-CCL25 and anti-CCR9 antibodies |
| US8512701B2 (en) | 2002-11-15 | 2013-08-20 | Morehouse School Of Medicine | Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration |
| JP2007535579A (ja) | 2004-04-29 | 2007-12-06 | イェール ユニバーシティ | 炎症性疾患およびウイルス関連性呼吸器疾患を処置するためのヌクレアーゼ耐性外部ガイド配列 |
| US7476733B2 (en) | 2005-03-25 | 2009-01-13 | The United States Of America As Represented By The Department Of Health And Human Services | Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease |
| US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| EP2392647A1 (en) | 2005-10-14 | 2011-12-07 | MUSC Foundation For Research Development | Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy |
| EP1998792B1 (en) | 2006-03-01 | 2015-02-18 | The University of Utah Research Foundation | Methods and compositions related to cyclic peptide synthesis |
| US8470965B2 (en) | 2006-03-01 | 2013-06-25 | University Of Utah Research Foundation | Methods and compositions related to cyclic peptide synthesis |
| US20100190689A1 (en) | 2006-09-21 | 2010-07-29 | University Of Rochester | Compositions and methods related to protein displacement therapy for myotonic distrophy |
| US8999317B2 (en) | 2006-11-01 | 2015-04-07 | University Of Rochester | Methods and compositions related to the structure and function of APOBEC3G |
| US9896511B2 (en) | 2007-01-10 | 2018-02-20 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies |
| WO2010070380A2 (en) | 2007-12-03 | 2010-06-24 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health | Doc1 compositions and methods for treating cancer |
| WO2009114614A2 (en) | 2008-03-11 | 2009-09-17 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
| US9822364B2 (en) | 2008-03-11 | 2017-11-21 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
| US20110262395A1 (en) | 2008-05-08 | 2011-10-27 | University Of Utah Research Foundation | Sensory receptors for chronic fatigue and pain and uses thereof |
| EP2370080A1 (en) | 2008-12-02 | 2011-10-05 | University of Utah Research Foundation | Pde1 as a target therapeutic in heart disease |
| WO2010074924A1 (en) | 2008-12-23 | 2010-07-01 | University Of Utah Research Foundation | Identification and regulation of a novel dna demethylase system |
| WO2010151638A1 (en) | 2009-06-25 | 2010-12-29 | Medical College Of Georgia Research Institute, Inc. | Jnk inhibitors for use in treating spinal muscular atrophy |
| US20110060000A1 (en) | 2009-09-10 | 2011-03-10 | Maurizio Grimaldi | Acridine analogs in the treatment of gliomas |
| US20110274745A1 (en) | 2009-11-10 | 2011-11-10 | Lipella Pharmaceuticals Inc. | Instillation of liposomal formulation of sirna and antisense oligonucleotides |
| WO2011082231A1 (en) | 2009-12-31 | 2011-07-07 | New York University | Compositions and methods for promoting epithelialization and wound closure |
| US20110207789A1 (en) | 2010-02-19 | 2011-08-25 | Ye Fang | Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents |
| CN106177930A (zh) | 2010-12-14 | 2016-12-07 | 吉安特科技股份有限公司 | 抗cxcl13抗体和抗cxcr5抗体在恶性肿瘤的治疗或检测中的用途 |
| EP2709664A4 (en) | 2011-05-20 | 2015-06-10 | Us Government | BLOCKADE OF TL1A-DR3 INTERACTIONS FOR THE TREATMENT OF T-CELL-MEDIATED DISEASES AND ANTIBODIES THEREOF |
| US9801948B2 (en) | 2011-09-21 | 2017-10-31 | Yale University | Antimicrobial compositions and methods of use thereof |
| KR101343959B1 (ko) | 2012-09-19 | 2013-12-24 | 한국기계연구원 | 통합 코팅 장치 |
| SG11201703397UA (en) | 2014-10-27 | 2017-05-30 | Univ Central Florida Res Found | Methods and compositions for natural killer cells |
| AU2017306422A1 (en) | 2016-08-03 | 2019-01-31 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | TLR9 targeted therapeutics |
| WO2019051355A1 (en) | 2017-09-08 | 2019-03-14 | Ohio State Innovation Foundation | NEW MICROARN INHIBITOR THERAPY FOR SYSTEMIC LUPUS ERYTHEMATOSUS |
| CN113950525B (zh) * | 2021-01-27 | 2022-06-03 | Cj第一制糖株式会社 | 新型核糖核酸酶p变体及使用其生产l-谷氨酸的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| JP2750127B2 (ja) * | 1988-07-29 | 1998-05-13 | 三共株式会社 | リボザイムによるポリリボヌクレオチド特定部位の切断方法 |
| US5168053A (en) * | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
-
1993
- 1993-04-28 EP EP93910848A patent/EP0638121B1/en not_active Expired - Lifetime
- 1993-04-28 ES ES93910848T patent/ES2093427T3/es not_active Expired - Lifetime
- 1993-04-28 CA CA002117903A patent/CA2117903C/en not_active Expired - Fee Related
- 1993-04-28 DK DK93910848.6T patent/DK0638121T3/da active
- 1993-04-28 WO PCT/US1993/003961 patent/WO1993022434A2/en not_active Ceased
- 1993-04-28 AU AU41198/93A patent/AU669367B2/en not_active Ceased
- 1993-04-28 AT AT93910848T patent/ATE140482T1/de not_active IP Right Cessation
- 1993-04-28 DE DE69303712T patent/DE69303712T2/de not_active Expired - Fee Related
- 1993-04-28 JP JP5519468A patent/JP3015463B2/ja not_active Expired - Fee Related
-
1996
- 1996-08-22 GR GR960402216T patent/GR3020859T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2117903C (en) | 1999-01-12 |
| JP3015463B2 (ja) | 2000-03-06 |
| WO1993022434A3 (en) | 1993-12-23 |
| DE69303712T2 (de) | 1997-02-20 |
| AU669367B2 (en) | 1996-06-06 |
| JPH07507683A (ja) | 1995-08-31 |
| ES2093427T3 (es) | 1996-12-16 |
| WO1993022434A2 (en) | 1993-11-11 |
| GR3020859T3 (en) | 1996-11-30 |
| ATE140482T1 (de) | 1996-08-15 |
| CA2117903A1 (en) | 1993-11-11 |
| EP0638121A1 (en) | 1995-02-15 |
| DE69303712D1 (de) | 1996-08-22 |
| AU4119893A (en) | 1993-11-29 |
| EP0638121B1 (en) | 1996-07-17 |
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