ATE140482T1 - Gezielte spaltung von rna mittels eukaryontischer rnase p und externe führungssequenz - Google Patents
Gezielte spaltung von rna mittels eukaryontischer rnase p und externe führungssequenzInfo
- Publication number
- ATE140482T1 ATE140482T1 AT93910848T AT93910848T ATE140482T1 AT E140482 T1 ATE140482 T1 AT E140482T1 AT 93910848 T AT93910848 T AT 93910848T AT 93910848 T AT93910848 T AT 93910848T AT E140482 T1 ATE140482 T1 AT E140482T1
- Authority
- AT
- Austria
- Prior art keywords
- egs
- rna
- rnaase
- cleavage
- loop
- Prior art date
Links
- 238000003776 cleavage reaction Methods 0.000 title abstract 5
- 230000007017 scission Effects 0.000 title abstract 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 6
- 108020005098 Anticodon Proteins 0.000 abstract 3
- 108020004566 Transfer RNA Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108091027075 5S-rRNA precursor Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/126—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes involving RNAse P
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87509992A | 1992-04-28 | 1992-04-28 | |
| US93193792A | 1992-08-18 | 1992-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE140482T1 true ATE140482T1 (de) | 1996-08-15 |
Family
ID=27128368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93910848T ATE140482T1 (de) | 1992-04-28 | 1993-04-28 | Gezielte spaltung von rna mittels eukaryontischer rnase p und externe führungssequenz |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0638121B1 (de) |
| JP (1) | JP3015463B2 (de) |
| AT (1) | ATE140482T1 (de) |
| AU (1) | AU669367B2 (de) |
| CA (1) | CA2117903C (de) |
| DE (1) | DE69303712T2 (de) |
| DK (1) | DK0638121T3 (de) |
| ES (1) | ES2093427T3 (de) |
| GR (1) | GR3020859T3 (de) |
| WO (1) | WO1993022434A2 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
| US6057153A (en) * | 1995-01-13 | 2000-05-02 | Yale University | Stabilized external guide sequences |
| US5683873A (en) * | 1995-01-13 | 1997-11-04 | Innovir Laboratories, Inc. | EGS-mediated inactivation of target RNA |
| US5877162A (en) * | 1996-03-14 | 1999-03-02 | Innovir Laboratories, Inc. | Short external guide sequences |
| US6610478B1 (en) | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
| CA2310510C (en) * | 1997-11-21 | 2007-04-17 | Yale University | Method for identifying and inhibiting functional nucleic acid molecules in cells |
| US6013447A (en) * | 1997-11-21 | 2000-01-11 | Innovir Laboratories, Inc. | Random intracellular method for obtaining optimally active nucleic acid molecules |
| US6248525B1 (en) | 1998-03-30 | 2001-06-19 | Yale University | Method for identifying essential or functional genes |
| EP1326892A2 (de) | 2000-10-12 | 2003-07-16 | University of Rochester | Zusammensetzungen die die proliferation von krebszellen hemmen |
| EP1572168B1 (de) | 2002-02-06 | 2010-05-26 | Vicor Technologies, Inc. | Anti-infarkt-moleküle |
| AU2003257181A1 (en) | 2002-08-05 | 2004-02-23 | University Of Rochester | Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof |
| US8658377B2 (en) | 2002-11-15 | 2014-02-25 | Morehouse School Of Medicine | Detecting cancer with anti-CCL25 and anti-CCR9 antibodies |
| US8512701B2 (en) | 2002-11-15 | 2013-08-20 | Morehouse School Of Medicine | Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US9233120B2 (en) | 2002-11-15 | 2016-01-12 | Jyant Technologies | Anti-CCL25 and anti-CCR9 antibodies for the prevention and treatment of cancer and cancer cell migration |
| AU2005330566B2 (en) | 2004-04-29 | 2008-09-18 | Yale University | Nuclease resistant external guide sequences for treating inflammatory and viral related respiratory diseases |
| US7476733B2 (en) | 2005-03-25 | 2009-01-13 | The United States Of America As Represented By The Department Of Health And Human Services | Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease |
| EP2392647A1 (de) | 2005-10-14 | 2011-12-07 | MUSC Foundation For Research Development | Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie |
| US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| US9365622B2 (en) | 2006-03-01 | 2016-06-14 | University Of Utah Research Foundation | Methods and compositions related to cyclic peptide synthesis |
| US8470965B2 (en) | 2006-03-01 | 2013-06-25 | University Of Utah Research Foundation | Methods and compositions related to cyclic peptide synthesis |
| EP3034083B1 (de) | 2006-09-21 | 2020-12-09 | University of Rochester | Antisense-oligonukleotide zur behandlung von myotoner dystrophie |
| US8999317B2 (en) | 2006-11-01 | 2015-04-07 | University Of Rochester | Methods and compositions related to the structure and function of APOBEC3G |
| US9896511B2 (en) | 2007-01-10 | 2018-02-20 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies |
| WO2010070380A2 (en) | 2007-12-03 | 2010-06-24 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health | Doc1 compositions and methods for treating cancer |
| US9822364B2 (en) | 2008-03-11 | 2017-11-21 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
| WO2009114614A2 (en) | 2008-03-11 | 2009-09-17 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
| US20110262395A1 (en) | 2008-05-08 | 2011-10-27 | University Of Utah Research Foundation | Sensory receptors for chronic fatigue and pain and uses thereof |
| US20120070443A1 (en) | 2008-12-02 | 2012-03-22 | University Of Utah Research Foundation | Pde1 as a target therapeutic in heart disease |
| WO2010074924A1 (en) | 2008-12-23 | 2010-07-01 | University Of Utah Research Foundation | Identification and regulation of a novel dna demethylase system |
| WO2010151638A1 (en) | 2009-06-25 | 2010-12-29 | Medical College Of Georgia Research Institute, Inc. | Jnk inhibitors for use in treating spinal muscular atrophy |
| WO2011031974A1 (en) | 2009-09-10 | 2011-03-17 | Southern Research Institute | Acridine analogs in the treatment of gliomas |
| US20110274745A1 (en) | 2009-11-10 | 2011-11-10 | Lipella Pharmaceuticals Inc. | Instillation of liposomal formulation of sirna and antisense oligonucleotides |
| WO2011082231A1 (en) | 2009-12-31 | 2011-07-07 | New York University | Compositions and methods for promoting epithelialization and wound closure |
| US20110207789A1 (en) | 2010-02-19 | 2011-08-25 | Ye Fang | Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents |
| CN103608680A (zh) | 2010-12-14 | 2014-02-26 | 詹姆士·W·里拉尔德 | 抗cxcl13抗体和抗cxcr5抗体在恶性肿瘤的治疗或检测中的用途 |
| KR20140104344A (ko) | 2011-05-20 | 2014-08-28 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스 | Ｔ 세포 매개성 질병의 병증을 개선하기 위한 ｔｌ１ａ-ｄｒ３의 상호작용의 차단 및 그것의 항체 |
| US9801948B2 (en) | 2011-09-21 | 2017-10-31 | Yale University | Antimicrobial compositions and methods of use thereof |
| KR101343959B1 (ko) | 2012-09-19 | 2013-12-24 | 한국기계연구원 | 통합 코팅 장치 |
| EP3223856B1 (de) | 2014-10-27 | 2025-09-24 | University of Central Florida Research Foundation, Inc. | Verfahren und zusammensetzungen für natürliche killerzellen |
| AU2017306422A1 (en) | 2016-08-03 | 2019-01-31 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | TLR9 targeted therapeutics |
| WO2019051355A1 (en) | 2017-09-08 | 2019-03-14 | Ohio State Innovation Foundation | NEW MICROARN INHIBITOR THERAPY FOR SYSTEMIC LUPUS ERYTHEMATOSUS |
| CN113950525B (zh) * | 2021-01-27 | 2022-06-03 | Cj第一制糖株式会社 | 新型核糖核酸酶p变体及使用其生产l-谷氨酸的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| JP2750127B2 (ja) * | 1988-07-29 | 1998-05-13 | 三共株式会社 | リボザイムによるポリリボヌクレオチド特定部位の切断方法 |
| US5168053A (en) * | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
-
1993
- 1993-04-28 JP JP5519468A patent/JP3015463B2/ja not_active Expired - Fee Related
- 1993-04-28 AT AT93910848T patent/ATE140482T1/de not_active IP Right Cessation
- 1993-04-28 EP EP93910848A patent/EP0638121B1/de not_active Expired - Lifetime
- 1993-04-28 DE DE69303712T patent/DE69303712T2/de not_active Expired - Fee Related
- 1993-04-28 CA CA002117903A patent/CA2117903C/en not_active Expired - Fee Related
- 1993-04-28 AU AU41198/93A patent/AU669367B2/en not_active Ceased
- 1993-04-28 WO PCT/US1993/003961 patent/WO1993022434A2/en not_active Ceased
- 1993-04-28 DK DK93910848.6T patent/DK0638121T3/da active
- 1993-04-28 ES ES93910848T patent/ES2093427T3/es not_active Expired - Lifetime
-
1996
- 1996-08-22 GR GR960402216T patent/GR3020859T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69303712D1 (de) | 1996-08-22 |
| CA2117903C (en) | 1999-01-12 |
| EP0638121A1 (de) | 1995-02-15 |
| GR3020859T3 (en) | 1996-11-30 |
| EP0638121B1 (de) | 1996-07-17 |
| ES2093427T3 (es) | 1996-12-16 |
| AU669367B2 (en) | 1996-06-06 |
| JPH07507683A (ja) | 1995-08-31 |
| WO1993022434A3 (en) | 1993-12-23 |
| WO1993022434A2 (en) | 1993-11-11 |
| DK0638121T3 (da) | 1996-08-12 |
| DE69303712T2 (de) | 1997-02-20 |
| JP3015463B2 (ja) | 2000-03-06 |
| AU4119893A (en) | 1993-11-29 |
| CA2117903A1 (en) | 1993-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |