WO1998037185A3 - Vectors for controlled gene expression - Google Patents
Vectors for controlled gene expression Download PDFInfo
- Publication number
- WO1998037185A3 WO1998037185A3 PCT/US1998/003092 US9803092W WO9837185A3 WO 1998037185 A3 WO1998037185 A3 WO 1998037185A3 US 9803092 W US9803092 W US 9803092W WO 9837185 A3 WO9837185 A3 WO 9837185A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vectors
- gene expression
- tetracycline
- disclosed
- regulated
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4736—Retinoblastoma protein
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3875597P | 1997-02-20 | 1997-02-20 | |
US60/038,755 | 1997-02-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998037185A2 WO1998037185A2 (en) | 1998-08-27 |
WO1998037185A3 true WO1998037185A3 (en) | 1998-11-26 |
Family
ID=21901713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/003092 WO1998037185A2 (en) | 1997-02-20 | 1998-02-19 | Vectors for controlled gene expression |
Country Status (1)
Country | Link |
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WO (1) | WO1998037185A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999042581A1 (en) | 1998-02-19 | 1999-08-26 | Eastern Virginia Medical School | RECOMBINANT ACTIVE HUMAN ZONA PELLUCIDA PROTEIN 3 (hZP3) |
US7037663B2 (en) | 1998-02-19 | 2006-05-02 | Eastern Virginia Medical School | Human zona pellucida protein 3 and uses thereof |
FR2782732A1 (en) * | 1998-08-28 | 2000-03-03 | Transgene Sa | INDUCTIBLE EXPRESSION SYSTEM |
ES2259846T3 (en) * | 1998-10-19 | 2006-10-16 | Powderject Vaccines, Inc. | MINIMUM PROMOTERS AND USE OF THE SAME. |
AU1344200A (en) * | 1998-11-06 | 2000-05-29 | Musc Foundation For Research Development | A method of treating tumors using fas-induced apoptosis |
WO2000028062A1 (en) * | 1998-11-09 | 2000-05-18 | Aventis Pharma S.A. | Novel system for regulating transgene expression |
FR2786198B1 (en) * | 1998-11-09 | 2003-02-14 | Aventis Pharma Sa | NEW SYSTEM FOR REGULATING EXPRESSION OF A TRANSGEN |
CZ20013813A3 (en) * | 1999-04-26 | 2002-02-13 | Aventis Pharma S. A. | Use of defective recombinant adenovirus vector containing nucleic acid encoding angiogenic factor for preparing a medicament intended for treating lung hypertension |
FR2792531B1 (en) * | 1999-04-26 | 2003-01-31 | Aventis Pharma Sa | USE OF DEFECTIVE RECOMBINANT ADENOVIRUS COMPRISING A NUCLEIC ACID ENCODING AN ANGIOGENIC FACTOR FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION |
EP1083230A1 (en) * | 1999-09-10 | 2001-03-14 | Academisch Medisch Centrum Amsterdam | Viral replicons and viruses dependent on inducing agents |
WO2002054851A2 (en) * | 2001-01-12 | 2002-07-18 | Sbarro Institute For Cancer Research And Molecular Medicine | Inhibition of pathological angiogenesis in vivo |
WO2002070719A2 (en) * | 2001-01-19 | 2002-09-12 | Trustees Of The University Of Pennsylvania | Regulatable gene expression system |
WO2002090533A2 (en) * | 2001-05-07 | 2002-11-14 | National Research Council Of Canada | Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells |
WO2003011118A2 (en) | 2001-08-02 | 2003-02-13 | Trinity Biomedical Technology Corporation | Human zona pellucida proteins and methods of their use in diagnosing male infertility |
WO2004026903A2 (en) * | 2002-09-20 | 2004-04-01 | Akzo Nobel N.V. | Live antenuated parasite vaccine |
WO2005037297A1 (en) * | 2003-10-10 | 2005-04-28 | Gary Aronson | Compositions and methods for inhibiting cell senescence and hyperproliferative disorders |
CN114410689B (en) * | 2022-03-29 | 2022-06-17 | 北京循生生物医学研究有限公司 | Preparation method for enhancing lethality of tumor infiltrating lymphocytes |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994006910A1 (en) * | 1992-09-18 | 1994-03-31 | Canji, Inc. | Gene therapy by retroviral vector with tumor suppressive gene |
WO1994021115A1 (en) * | 1993-03-25 | 1994-09-29 | Baylor College Of Medicine | Broad spectrum tumor suppressor genes, gene products and methods for tumor suppression gene therapy |
WO1994028152A1 (en) * | 1993-05-28 | 1994-12-08 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
WO1996001313A1 (en) * | 1994-07-01 | 1996-01-18 | Hermann Bujard | Tetracycline-regulated transcriptional modulators |
WO1996031242A1 (en) * | 1995-04-07 | 1996-10-10 | Albert Einstein College Of Medicine Of Yeshiva University | RECOMBINANT β-CELL AND USES THEREOF |
WO1996040946A1 (en) * | 1995-06-07 | 1996-12-19 | Yale University | An autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes |
-
1998
- 1998-02-19 WO PCT/US1998/003092 patent/WO1998037185A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994006910A1 (en) * | 1992-09-18 | 1994-03-31 | Canji, Inc. | Gene therapy by retroviral vector with tumor suppressive gene |
WO1994021115A1 (en) * | 1993-03-25 | 1994-09-29 | Baylor College Of Medicine | Broad spectrum tumor suppressor genes, gene products and methods for tumor suppression gene therapy |
WO1994028152A1 (en) * | 1993-05-28 | 1994-12-08 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
WO1996001313A1 (en) * | 1994-07-01 | 1996-01-18 | Hermann Bujard | Tetracycline-regulated transcriptional modulators |
WO1996031242A1 (en) * | 1995-04-07 | 1996-10-10 | Albert Einstein College Of Medicine Of Yeshiva University | RECOMBINANT β-CELL AND USES THEREOF |
WO1996040946A1 (en) * | 1995-06-07 | 1996-12-19 | Yale University | An autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes |
Non-Patent Citations (5)
Title |
---|
A. HOFFMANN ET AL.,: "Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassete", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 93, 1996, WASINGTON, DC, US, pages 5185 - 5190, XP002015266 * |
H-J. XU ET AL.,: "Enhanced tumor supressor gene therapy via replication-deficient adenovirus vectors expressing an N-terminal truncated retinoblastoma protein", CANCER RESEARCH, vol. 56, no. 10, 1996, OXFORD, GB, pages 2245 - 2249, XP002068733 * |
H-J. XU ET AL.,: "Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition", ONCOGENE, vol. 15, no. 21, 1997, BASINGSTOCKE, GB, pages 2589 - 2596, XP002068735 * |
M. GOSSEN AND H. BUJARD: "Tight control of gene expression in mammalian cells by tetracycline responsive promoters", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 89, no. 12, 1992, WASIHNGTON, DC, US, pages 5547 - 5551, XP000564458 * |
S-X. HU ET AL.,: "Developement of an adenovirus vector with tetracycline-regulatable human tumor necrosis factor alpha gene expression", CANCER RESEARCH, vol. 57, no. 16, 15 August 1997 (1997-08-15), OXFORD, GB, pages 3339 - 3343, XP002068734 * |
Also Published As
Publication number | Publication date |
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WO1998037185A2 (en) | 1998-08-27 |
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