DK0612349T3 - Nyt thrombininhiberende protein fra rovmider - Google Patents

Nyt thrombininhiberende protein fra rovmider

Info

Publication number
DK0612349T3
DK0612349T3 DK92922434.3T DK92922434T DK0612349T3 DK 0612349 T3 DK0612349 T3 DK 0612349T3 DK 92922434 T DK92922434 T DK 92922434T DK 0612349 T3 DK0612349 T3 DK 0612349T3
Authority
DK
Denmark
Prior art keywords
pct
inhibitory protein
cys
gly
thrombin inhibitory
Prior art date
Application number
DK92922434.3T
Other languages
Danish (da)
English (en)
Inventor
Siegfried Bialojan
Thomas Friedrich
Christoph Kuenast
Burkhard Kroeger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0612349T3 publication Critical patent/DK0612349T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/856—Snakes; venom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK92922434.3T 1991-11-06 1992-10-27 Nyt thrombininhiberende protein fra rovmider DK0612349T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4136513A DE4136513A1 (de) 1991-11-06 1991-11-06 Neues thrombininhibitorisches protein aus raubwanzen

Publications (1)

Publication Number Publication Date
DK0612349T3 true DK0612349T3 (da) 1997-07-28

Family

ID=6444190

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92922434.3T DK0612349T3 (da) 1991-11-06 1992-10-27 Nyt thrombininhiberende protein fra rovmider

Country Status (10)

Country Link
US (1) US5523287A (fr)
EP (1) EP0612349B1 (fr)
JP (1) JPH07500964A (fr)
AT (1) ATE149568T1 (fr)
CA (1) CA2121352A1 (fr)
DE (2) DE4136513A1 (fr)
DK (1) DK0612349T3 (fr)
ES (1) ES2097931T3 (fr)
MX (1) MX9206339A (fr)
WO (1) WO1993009232A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19848785A1 (de) * 1998-10-22 2000-04-27 Max Planck Gesellschaft Gen für einen Thrombininhibitor aus Raubwanzen und Protein mit thrombinhemmender Wirkung
JP4805461B2 (ja) * 1999-03-18 2011-11-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 血小板接着の阻止用タンパク質
MY128992A (en) 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen
US7691839B2 (en) 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1092421A (en) * 1964-02-28 1967-11-22 Nat Res Dev Improvements relating to anticoagulant materials
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
US5019056A (en) * 1988-09-22 1991-05-28 Aegis Medical, Inc. Bowel care apparatus
DE3931839A1 (de) * 1989-09-23 1991-04-04 Basf Ag Neue proteine und ihre herstellung

Also Published As

Publication number Publication date
ATE149568T1 (de) 1997-03-15
US5523287A (en) 1996-06-04
MX9206339A (es) 1993-05-01
EP0612349A1 (fr) 1994-08-31
WO1993009232A1 (fr) 1993-05-13
ES2097931T3 (es) 1997-04-16
CA2121352A1 (fr) 1993-05-13
DE59208142D1 (de) 1997-04-10
DE4136513A1 (de) 1993-05-13
JPH07500964A (ja) 1995-02-02
EP0612349B1 (fr) 1997-03-05

Similar Documents

Publication Publication Date Title
DK0667910T3 (da) En Bacillus-promoter, afledt fra en variant af en alpha-amylase-promoter fra Bacillus licheniformis
ATE133181T1 (de) Dehydrodidemnin b
ES2062549T3 (es) Proteina anticoagulante.
SE9103332L (sv) Metod foer diagnos av blodkoagulationssjukdomar
DE60035412D1 (de) Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren
DE69432140D1 (de) Verfahren zur Herstellung von 9-Desoxotaxanen
ATE349892T1 (de) Schädlingsbekämpfungsmittel
NO941681D0 (no) Humane IL-4 mutant proteiner
DE69228749D1 (de) Neuartige polypeptide und ihre verwendung
DE69225410D1 (de) Herstellung von n-acetylneuraminsäure-derivaten
ATE339878T1 (de) Myc-bindende zinkfinger-proteine, ihre herstellung und ihre verwendung
DK0612349T3 (da) Nyt thrombininhiberende protein fra rovmider
ATE237634T1 (de) Analogen des keratinozytenwachstumfaktors
EP1132402A4 (fr) Fragments peptidiques a activite inhibitrice de la mort cellulaire
DE69302375D1 (de) Kosmetische zusammensetzung zur erhaltung der frisur enthaltend ein milchprotein und/oder ein milchproteinhydrolysate und ein hydrolysate
DK0609242T3 (da) Nyt thrombininhibitorisk protein fra blodmider
DK0610246T3 (da) Hidtil ukendt thrombininhiberende protein fra blodmider
DE69619530D1 (de) Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität
DK0616642T3 (da) Hidtil ukendte thrombininhibitoriske proteiner fra landblodigler
ATE216707T1 (de) Peptide und ihre verwendung in der therapie von krankheiten des zöliakie-formenkreises
ATE94168T1 (de) Peptide.
NO945021L (no) Sammensetninger for inhibisjon av proteinhormondannelse og anvendelse derav
HUP9601528A2 (hu) Véralvadásgátló hatású peptidszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények