DK0592434T3 - Forbedret fremgangsmåde til syntese af oligomerer - Google Patents
Forbedret fremgangsmåde til syntese af oligomererInfo
- Publication number
- DK0592434T3 DK0592434T3 DK91919675T DK91919675T DK0592434T3 DK 0592434 T3 DK0592434 T3 DK 0592434T3 DK 91919675 T DK91919675 T DK 91919675T DK 91919675 T DK91919675 T DK 91919675T DK 0592434 T3 DK0592434 T3 DK 0592434T3
- Authority
- DK
- Denmark
- Prior art keywords
- oligomers
- synthesis
- improved method
- methods
- result
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60579090A | 1990-10-26 | 1990-10-26 | |
| PCT/US1991/007630 WO1992007864A1 (en) | 1990-10-26 | 1991-10-21 | Improved process for the synthesis of oligomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0592434T3 true DK0592434T3 (da) | 1999-06-21 |
Family
ID=24425218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91919675T DK0592434T3 (da) | 1990-10-26 | 1991-10-21 | Forbedret fremgangsmåde til syntese af oligomerer |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5726300A (cs) |
| EP (1) | EP0592434B1 (cs) |
| JP (1) | JPH06509542A (cs) |
| AT (1) | ATE171947T1 (cs) |
| AU (1) | AU669103B2 (cs) |
| CA (1) | CA2094803A1 (cs) |
| DE (1) | DE69130331T2 (cs) |
| DK (1) | DK0592434T3 (cs) |
| ES (1) | ES2124231T3 (cs) |
| IE (1) | IE913761A1 (cs) |
| IL (1) | IL99844A (cs) |
| NZ (1) | NZ240325A (cs) |
| TW (1) | TW216423B (cs) |
| WO (1) | WO1992007864A1 (cs) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0616612A4 (en) | 1991-12-12 | 1995-01-11 | Gilead Sciences Inc | NUCLEASE-STABLE OLIGOMERS SUITABLE FOR BINDING AND METHODS OF USE. |
| WO1994001446A2 (en) * | 1992-07-09 | 1994-01-20 | Beckman Instruments, Inc. | Derivatized organic solid support for nucleic acid synthesis |
| FR2707296B1 (fr) * | 1993-07-09 | 1995-09-29 | Genset Sa | Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé. |
| JPH09501562A (ja) * | 1993-07-19 | 1997-02-18 | ジェン−プローブ・インコーポレイテッド | ヒト・免疫不全ウイルスに対する活性を有するオリゴヌクレオチド |
| AU692816B2 (en) * | 1993-07-19 | 1998-06-18 | Gen-Probe Incorporated | Oligonucleotide screening assay |
| US5739309A (en) * | 1993-07-19 | 1998-04-14 | Gen-Probe Incorporated | Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens |
| US5733781A (en) | 1994-07-19 | 1998-03-31 | Gen-Probe Incorporated | Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus |
| JP3124036B2 (ja) * | 1995-01-19 | 2001-01-15 | ジェン−プローブ・インコーポレーテッド | ライム病関連ボレリアに対する核酸増幅オリゴヌクレオチドおよびプローブ |
| US5747252A (en) | 1995-06-07 | 1998-05-05 | Gen-Probe Incorporated | Nucleic acid probes and amplification oligonucleotides for Neisseria species |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| US5716846A (en) * | 1995-06-07 | 1998-02-10 | Gen-Probe Incorporated | Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA |
| US5747470A (en) * | 1995-06-07 | 1998-05-05 | Gen-Probe Incorporated | Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA |
| US5674995A (en) * | 1995-06-07 | 1997-10-07 | Gen-Probe Incorporated | Oligonucleotides specific for cytokine signal transducer gp130 mRNA |
| US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
| US6146833A (en) * | 1997-02-11 | 2000-11-14 | Beckman Coulter, Inc. | Polymeric reagents for immobilizing biopolymers |
| US7435390B2 (en) * | 2001-01-26 | 2008-10-14 | Third Wave Technologies, Inc. | Nucleic acid synthesizers |
| US20030072689A1 (en) * | 2001-08-15 | 2003-04-17 | Third Wave Technologies, Inc. | Polymer synthesizer |
| US6932943B1 (en) | 2001-01-26 | 2005-08-23 | Third Wave Technologies | Nucleic acid synthesizers |
| WO2008016988A1 (en) | 2006-08-01 | 2008-02-07 | Gen-Probe Incorporated | Methods of nonspecific target capture of nucleic acids |
| SI2757091T1 (en) | 2008-04-01 | 2018-01-31 | Biosearch Technologies, Inc. | Stabilized nucleic acid black gas-fluorofor probe |
| US10913767B2 (en) * | 2010-04-22 | 2021-02-09 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| KR102237882B1 (ko) | 2012-08-15 | 2021-04-07 | 아이오니스 파마수티컬즈, 인코포레이티드 | 변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법 |
| ES2707062T3 (es) | 2014-05-09 | 2019-04-02 | Biosearch Tech Inc | Extintores cósmicos |
| US10618926B2 (en) | 2015-04-02 | 2020-04-14 | Merck Sharp & Dohme | Process for making phosphoramidate protected nucleoside compounds |
| CN107922454B (zh) | 2015-04-15 | 2021-10-22 | 生物检索技术股份有限公司 | 双猝灭剂探针 |
| CN110612354B (zh) | 2017-05-11 | 2025-02-11 | 简·探针公司 | 用于分离靶核酸的组合物和方法 |
| US20220396786A1 (en) | 2019-11-14 | 2022-12-15 | Gen-Probe Incorporated | Compositions and Methods for Capturing Target Nucleic Acids |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4415732A (en) * | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| DE3329892A1 (de) * | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| US4923901A (en) * | 1987-09-04 | 1990-05-08 | Millipore Corporation | Membranes with bound oligonucleotides and peptides |
-
1991
- 1991-10-21 JP JP3518321A patent/JPH06509542A/ja active Pending
- 1991-10-21 WO PCT/US1991/007630 patent/WO1992007864A1/en not_active Ceased
- 1991-10-21 DE DE69130331T patent/DE69130331T2/de not_active Expired - Fee Related
- 1991-10-21 DK DK91919675T patent/DK0592434T3/da active
- 1991-10-21 EP EP91919675A patent/EP0592434B1/en not_active Expired - Lifetime
- 1991-10-21 AU AU88753/91A patent/AU669103B2/en not_active Ceased
- 1991-10-21 AT AT91919675T patent/ATE171947T1/de not_active IP Right Cessation
- 1991-10-21 ES ES91919675T patent/ES2124231T3/es not_active Expired - Lifetime
- 1991-10-21 CA CA002094803A patent/CA2094803A1/en not_active Abandoned
- 1991-10-23 NZ NZ240325A patent/NZ240325A/xx not_active IP Right Cessation
- 1991-10-24 IL IL9984491A patent/IL99844A/en not_active IP Right Cessation
- 1991-10-25 IE IE376191A patent/IE913761A1/en not_active Application Discontinuation
-
1992
- 1992-01-14 TW TW081100215A patent/TW216423B/zh active
-
1994
- 1994-06-15 US US08/260,392 patent/US5726300A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ240325A (en) | 1993-06-25 |
| CA2094803A1 (en) | 1992-04-27 |
| IL99844A (en) | 1995-07-31 |
| AU669103B2 (en) | 1996-05-30 |
| WO1992007864A1 (en) | 1992-05-14 |
| AU8875391A (en) | 1992-05-26 |
| DE69130331D1 (de) | 1998-11-12 |
| ATE171947T1 (de) | 1998-10-15 |
| EP0592434B1 (en) | 1998-10-07 |
| US5726300A (en) | 1998-03-10 |
| EP0592434A1 (en) | 1994-04-20 |
| TW216423B (cs) | 1993-11-21 |
| DE69130331T2 (de) | 1999-03-04 |
| JPH06509542A (ja) | 1994-10-27 |
| EP0592434A4 (en) | 1996-04-24 |
| ES2124231T3 (es) | 1999-02-01 |
| IE913761A1 (en) | 1992-05-22 |
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