|
WO1995018616A2
(en)
*
|
1994-01-03 |
1995-07-13 |
Acea Pharm Inc |
8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor
|
|
US5801183A
(en)
*
|
1995-01-27 |
1998-09-01 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists
|
|
US5646130A
(en)
*
|
1995-06-30 |
1997-07-08 |
Ocean University Of Oingdao |
Low molecular weight sulfated polysaccharides and uses thereof
|
|
ZA973884B
(en)
|
1996-05-23 |
1998-11-06 |
Du Pont Merck Pharma |
Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
|
|
EP1037590B1
(en)
|
1998-07-16 |
2004-04-14 |
Aaron Tabor |
Soy formulations and their use for promoting health
|
|
US6930101B1
(en)
|
1999-05-17 |
2005-08-16 |
The Regents Of The University Of California |
Thiazolopyrimidines useful as TNFα inhibitors
|
|
AU2003220401A1
(en)
|
2002-03-18 |
2003-10-08 |
Bristol-Myers Squibb Company |
Uracil derivatives as inhibitors of tnf-alpha converting enzyme (tace) and matrix metalloproteinases
|
|
US6861422B2
(en)
*
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
ME00541B
(me)
*
|
2003-05-23 |
2011-10-10 |
Zentaris Gmbh |
NOVI PIRIDOPIRAZINI I NJlUHOVA UPOTREBA KAO MODULATORA KlNAZA
|
|
DE10323345A1
(de)
*
|
2003-05-23 |
2004-12-16 |
Zentaris Gmbh |
Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
|
|
MY147767A
(en)
*
|
2004-06-16 |
2013-01-31 |
Janssen Pharmaceutica Nv |
Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
|
|
DE102004029784A1
(de)
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004033670A1
(de)
*
|
2004-07-09 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
|
|
US7728134B2
(en)
*
|
2004-08-14 |
2010-06-01 |
Boehringer Ingelheim International Gmbh |
Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
|
|
US7759485B2
(en)
*
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
|
US20060035903A1
(en)
*
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
|
US20060058311A1
(en)
*
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
US20060074088A1
(en)
*
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
|
EP1632493A1
(de)
*
|
2004-08-25 |
2006-03-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
EP1630163A1
(de)
*
|
2004-08-25 |
2006-03-01 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004058337A1
(de)
|
2004-12-02 |
2006-06-14 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
|
|
US7439358B2
(en)
*
|
2006-02-08 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
|
|
WO2007122466A1
(en)
*
|
2006-04-21 |
2007-11-01 |
Pfizer Products Inc. |
Pyridine[3,4-b]pyrazinones
|
|
US7601716B2
(en)
*
|
2006-05-01 |
2009-10-13 |
Cephalon, Inc. |
Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
|
|
GB0614471D0
(en)
*
|
2006-07-20 |
2006-08-30 |
Syngenta Ltd |
Herbicidal Compounds
|
|
US7981893B2
(en)
*
|
2006-10-19 |
2011-07-19 |
Signal Pharmaceuticals, Llc |
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
|
|
MX2009004019A
(es)
*
|
2006-10-19 |
2009-06-19 |
Signal Pharm Llc |
Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa.
|
|
WO2008063455A1
(en)
*
|
2006-11-13 |
2008-05-29 |
Hines Richard A |
Over-the wire exclusion device and system for delivery
|
|
JP5261487B2
(ja)
*
|
2007-08-03 |
2013-08-14 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ジヒドロプテリジノン誘導体の結晶形
|
|
US8110578B2
(en)
*
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
EA021377B9
(ru)
|
2008-12-09 |
2015-09-30 |
Джилид Сайэнс, Инк. |
Модуляторы толл-подобных рецепторов
|
|
BRPI1007358A2
(pt)
|
2009-01-23 |
2018-03-06 |
Takeda Pharmaceutical Company Limited |
inibidores de poli (adp-ribose) polimerase (parp)
|
|
WO2011014681A1
(en)
|
2009-07-30 |
2011-02-03 |
Takeda Pharmaceutical Company Limited |
Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS
|
|
SI2477987T1
(en)
*
|
2009-09-14 |
2018-03-30 |
Gilead Sciences, Inc. |
MODULATORS TO TOLL OF LIKE RECEPTORS
|
|
KR20120091240A
(ko)
|
2009-10-26 |
2012-08-17 |
시그날 파마소티칼 엘엘씨 |
헤테로아릴 화합물의 합성 및 정제 방법
|
|
PH12012501581A1
(en)
|
2010-02-03 |
2012-10-22 |
Signal Pharm Llc |
Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors
|
|
US8546566B2
(en)
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
US9370535B2
(en)
|
2011-05-17 |
2016-06-21 |
Boehringer Ingelheim International Gmbh |
Method for treatment of advanced solid tumors
|
|
SG10201912850WA
(en)
|
2011-10-19 |
2020-02-27 |
Signal Pharm Llc |
Treatment Of Cancer With TOR Kinase Inhibitors
|
|
US9351974B2
(en)
|
2011-11-10 |
2016-05-31 |
OSI Pharmaceuticals, LLC |
Substituted pteridinones for the treatment of cancer
|
|
SG11201402766UA
(en)
|
2011-12-02 |
2014-06-27 |
Signal Pharm Llc |
PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-3,4-DIHYDROPYRAZINO [2,3-<i>B</i>]PYRAZIN-2(1<i>H</i>)-ONE, A SOLID FORM THEREOF AND METHODS OF THEIR USE
|
|
KR102064626B1
(ko)
|
2012-02-24 |
2020-01-09 |
시그날 파마소티칼 엘엘씨 |
Tor 키나제 억제자 복합 치료법을 사용한 비소세포 폐암의 치료 방법
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
ES2638179T3
(es)
|
2013-01-16 |
2017-10-19 |
Signal Pharmaceuticals, Llc |
Compuestos de pirrolopirimidina sustituidos, composiciones de los mismos, y métodos de tratamiento con los mismos
|
|
US9474757B2
(en)
|
2013-04-17 |
2016-10-25 |
Signal Pharmaceuticals, Llc |
Methods for treating cancer using TOR kinase inhibitor combination therapy
|
|
MX374749B
(es)
|
2013-04-17 |
2025-03-06 |
Signal Pharm Llc |
Terapia de combinacion que comprende un inhibidor de tor cinasa y un analogo de citidina para tratar cancer.
|
|
KR20160002792A
(ko)
|
2013-04-17 |
2016-01-08 |
시그날 파마소티칼 엘엘씨 |
암 치료용 tor 키나제 억제제 및 n-(3-(5-플루오로-2-(4-(2-메톡시에톡시)페닐아미노)피리미딘-4-일아미노)페닐)아크릴아미드를 포함하는 병용 요법
|
|
WO2014172425A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
US9937169B2
(en)
|
2013-04-17 |
2018-04-10 |
Signal Pharmaceuticals, Llc |
Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
|
|
HK1221150A1
(zh)
|
2013-04-17 |
2017-05-26 |
西格诺药品有限公司 |
用二氢吡嗪并-吡嗪类对癌症的治疗
|
|
SG11201508527VA
(en)
|
2013-04-17 |
2015-11-27 |
Signal Pharm Llc |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
|
|
CA2912627C
(en)
|
2013-05-29 |
2022-03-15 |
Signal Pharmaceuticals, Llc |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
|
|
JP2016525532A
(ja)
|
2013-07-26 |
2016-08-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
骨髄異形成症候群の処置
|
|
JP2017514806A
(ja)
|
2014-04-16 |
2017-06-08 |
シグナル ファーマシューティカルズ,エルエルシー |
Torキナーゼ阻害剤組み合わせ療法を使用して癌を治療する方法
|
|
US9512129B2
(en)
|
2014-04-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
|
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
|
WO2015160882A1
(en)
|
2014-04-16 |
2015-10-22 |
Signal Pharmaceuticals, Llc |
SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
|
|
TWI733652B
(zh)
|
2014-07-11 |
2021-07-21 |
美商基利科學股份有限公司 |
用於治療HIV之toll樣受體調節劑
|
|
NZ629796A
(en)
|
2014-07-14 |
2015-12-24 |
Signal Pharm Llc |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
|
|
CN106715427A
(zh)
|
2014-07-14 |
2017-05-24 |
西格诺药品有限公司 |
利用取代的吡咯并嘧啶化合物、其组合物治疗癌症的方法
|
|
SI3194401T1
(sl)
|
2014-09-16 |
2020-12-31 |
Gilead Sciences, Inc. |
Trdne oblike modulatorja toličnega receptorja
|
|
PL3848375T3
(pl)
|
2014-09-16 |
2024-05-06 |
Gilead Sciences, Inc. |
Sposoby wytwarzania związków pośrednich dla modulatorów receptorów toll-podobnych
|
|
US9867831B2
(en)
|
2014-10-01 |
2018-01-16 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
|
|
KR102795129B1
(ko)
|
2017-06-22 |
2025-04-15 |
셀진 코포레이션 |
B형 간염 바이러스 감염을 특징으로 하는 간세포 암종의 치료
|
|
KR102272284B1
(ko)
*
|
2020-01-13 |
2021-07-02 |
금오공과대학교 산학협력단 |
정밀 압력제어가 가능한 다단 스프링 압력제어밸브
|
|
WO2025085554A1
(en)
*
|
2023-10-16 |
2025-04-24 |
Kronos Bio, Inc. |
Lysine acetyltransferase inhibitors
|