DK0585939T4 - TNF-ligander - Google Patents

TNF-ligander

Info

Publication number
DK0585939T4
DK0585939T4 DK93114141T DK93114141T DK0585939T4 DK 0585939 T4 DK0585939 T4 DK 0585939T4 DK 93114141 T DK93114141 T DK 93114141T DK 93114141 T DK93114141 T DK 93114141T DK 0585939 T4 DK0585939 T4 DK 0585939T4
Authority
DK
Denmark
Prior art keywords
ligands
tnf ligands
tnf
receptor
preparation
Prior art date
Application number
DK93114141T
Other languages
Danish (da)
English (en)
Other versions
DK0585939T3 (da
Inventor
David Wallach
Jacek Bigda
Igor Beletsky
Igor Mett
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26322501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0585939(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL10305192A external-priority patent/IL103051A/en
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of DK0585939T3 publication Critical patent/DK0585939T3/da
Application granted granted Critical
Publication of DK0585939T4 publication Critical patent/DK0585939T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK93114141T 1992-09-03 1993-09-03 TNF-ligander DK0585939T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL10305192A IL103051A (en) 1992-09-03 1992-09-03 Molecules binding to the p75 tnf receptor, their preparation and pharmaceutical compositions containing them
IL106271A IL106271A (en) 1992-09-03 1993-07-08 Ligand to TNF 75P receptor and its preparation

Publications (2)

Publication Number Publication Date
DK0585939T3 DK0585939T3 (da) 2002-05-06
DK0585939T4 true DK0585939T4 (da) 2008-07-21

Family

ID=26322501

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93114141T DK0585939T4 (da) 1992-09-03 1993-09-03 TNF-ligander

Country Status (10)

Country Link
EP (1) EP0585939B2 (ja)
JP (3) JP4044970B2 (ja)
AT (1) ATE212666T1 (ja)
AU (1) AU678369B2 (ja)
CA (1) CA2105534C (ja)
DE (1) DE69331510T3 (ja)
DK (1) DK0585939T4 (ja)
ES (1) ES2171404T5 (ja)
IL (1) IL106271A (ja)
PT (1) PT585939E (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107267A (en) * 1993-10-12 2009-07-20 Yeda Res & Dev Ligand to a member of the tnf/ngf receptor family
US5852173A (en) * 1994-10-19 1998-12-22 Genetics Institute, Inc. TNF receptor death ligand proteins and inhibitors of ligand binding
US5712381A (en) * 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
US5849501A (en) * 1994-10-19 1998-12-15 Genetics Institute, Inc. TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
US5847099A (en) * 1994-10-19 1998-12-08 Genetics Institute, Inc. TNF receptor death domain ligand proteins
US6824767B2 (en) 1994-11-07 2004-11-30 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US6599719B2 (en) 1994-11-07 2003-07-29 Human Genome Sciences, Inc. Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
US7078493B1 (en) 1995-03-15 2006-07-18 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like genes
US8110659B1 (en) 1995-03-15 2012-02-07 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like genes
US7094564B1 (en) 1995-03-15 2006-08-22 Human Genome Sciences, Inc. Human tumor necrosis factor receptor
US7427492B1 (en) 1995-06-05 2008-09-23 Human Genome Sciences, Inc. Polynucleotides encoding human tumor necrosis factor receptor-like2
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
US6713061B1 (en) 1996-03-12 2004-03-30 Human Genome Sciences, Inc. Death domain containing receptors
WO1997033904A1 (en) 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors
US7357927B2 (en) 1996-03-12 2008-04-15 Human Genome Sciences, Inc. Death domain containing receptors
CA2328509A1 (en) * 1998-05-18 1999-11-25 Applied Research Systems Ars Holding N.V Methods and use of compositions comprising tnf-rii(p75) agonists for treating asthma and other allergic conditions
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
JP2006509724A (ja) * 2002-08-01 2006-03-23 ワイス 炎症及びアポトーシスに関係する方法及び試薬
IL158287A0 (en) 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
EA012622B1 (ru) 2004-06-01 2009-10-30 Домэнтис Лимитед Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки
US9534044B2 (en) * 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2072330T5 (es) * 1989-05-18 2013-06-24 Yeda Research And Development Co., Ltd. Proteínas de unión II al Factor de Necrosis Tumoral, su purificación y anticuerpos frente a los mismos
DE4006269A1 (de) * 1990-02-28 1991-08-29 Max Planck Gesellschaft Antikoerper gegen den tumor-nekrosefaktor-rezeptor

Also Published As

Publication number Publication date
AU4612793A (en) 1994-03-10
CA2105534C (en) 2009-01-13
IL106271A (en) 2008-03-20
JP2006014742A (ja) 2006-01-19
ES2171404T5 (es) 2008-09-01
EP0585939A2 (en) 1994-03-09
DE69331510T2 (de) 2002-08-29
DK0585939T3 (da) 2002-05-06
EP0585939A3 (en) 1995-04-05
ES2171404T3 (es) 2002-09-16
JP2004254703A (ja) 2004-09-16
JP4044970B2 (ja) 2008-02-06
DE69331510T3 (de) 2008-11-06
EP0585939B2 (en) 2008-04-02
ATE212666T1 (de) 2002-02-15
EP0585939B1 (en) 2002-01-30
IL106271A0 (en) 1993-11-15
DE69331510D1 (de) 2002-03-14
AU678369B2 (en) 1997-05-29
JPH06315394A (ja) 1994-11-15
CA2105534A1 (en) 1994-03-04
PT585939E (pt) 2002-06-28

Similar Documents

Publication Publication Date Title
ATE212666T1 (de) Tnf-liganden
ATE44528T1 (de) Arzneimittel mit antipsychotischer wirkung.
DK264889A (da) To-fase-cementblanding, isaer til ortopaediske anvendelser
IL103510A0 (en) Pharmaceutical compositions containing antibodies for causing immunosuppression
DK175835B1 (da) Fremgangsmåde til fremstilling af en sammensætning, der omfatter en konjugation af 15A8-antistof
ATE199560T1 (de) Festphasensynthese von oligoribonucleotiden
GR930100259A (el) Μικροβιακή μέ?οδος παρασκευής μεβινολίνης.
FI101881B1 (fi) Menetelmä 3-aminopyridatsiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia asetyylikoliiniluonteisten reseptorien ligandeina
RU94022277A (ru) Новые 19-норстероиды, имеющие в положении 11 - бета феноксиалкилсульфонамидную или феноксиалкилсульфонилкарбамидную цепь, метод и промежуточные продукты их получения, и содержащая их фармацевтическая композиция
DK265587D0 (da) Farmaceutisk praeparat, der indeholder et polypeptid, til gastro-intestinal resorption
DK3095A (da) Fremgangsmåde til fremstilling af 2-aza-4-(alkoxycarbonyl)spiro[4,5]decan-3-oner
IT8420358A0 (it) Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti.
IS3589A7 (is) Aðferð við framleiðslu á efnasambandinu Indenoindoles I
ES2021515A6 (es) Procedimiento para la preparacion de compuestos derivados de isotiazolo-piridona azetidinil substituidos.
FI102380B1 (fi) Menetelmä peptidien valmistamiseksi kiinteäfaasisynteesin avulla
DE3470312D1 (de) Ether of n-propanolamine derivative
PT87780A (pt) A process for the preparation of cholecystokinin analogs for controlling appetite
FI91069B (fi) Menetelmä 5-C-hydroksimetyylialdoheksoosipohjaisten yhdisteiden valmistamiseksi
IS4052A (is) Aðferð til framleiðslu á 3- og 5- greinóttar (substituted) 1, 2, 3, 4-oxatriazole-5- imine efnasamböndum
DK0661263T3 (da) Fremgangsmåde til fremstilling af 2,4,5-tribrompyrrol-3-carbonitril
ES2027507A6 (es) Procedimiento de preparacion de derivados selenofenicos.
DK0377437T3 (da) Fremgangsmåde til fremstilling af 2,4-diamino-6-piperidinylpyrimidin-3-N-oxid
FI102166B1 (fi) Menetelmä N,N-dimetyyliaminometyyliaryyliyhdisteiden valmistamiseksi
ATE119779T1 (de) Verwendung von 5'-vinylhalo- aristeromycin/adenosin-analoga als immunsuppressiva.
FR2592651A1 (fr) Nouvelles phenyl naphtyridines comportant un substituant methyle en position 3, et les medicaments qui en contiennent.