ES2171404T3 - Ligandos del fnt. - Google Patents
Ligandos del fnt.Info
- Publication number
- ES2171404T3 ES2171404T3 ES93114141T ES93114141T ES2171404T3 ES 2171404 T3 ES2171404 T3 ES 2171404T3 ES 93114141 T ES93114141 T ES 93114141T ES 93114141 T ES93114141 T ES 93114141T ES 2171404 T3 ES2171404 T3 ES 2171404T3
- Authority
- ES
- Spain
- Prior art keywords
- ligands
- fnt
- receptor
- tnf
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE PREVEN LIGANDOS A UN ELEMENTO DE LA FAMILIA DE RECEPTORES TNF NGF. LOS LIGANDOS SE ENLAZAN A LA REGION DEL BUCLE DE CISTEINA TERMINAL C DE TAL RECEPTOR. UN PROCESO PARA LA PREPARACION DEL LIGANDO TAMBIEN SE PREVE, ASI COMO COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN LOS LIGANDOS
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL103051 | 1992-09-03 | ||
IL10305192A IL103051A (en) | 1992-09-03 | 1992-09-03 | Molecules binding to the p75 tnf receptor, their preparation and pharmaceutical compositions containing them |
IL106271 | 1993-07-08 | ||
IL106271A IL106271A (en) | 1992-09-03 | 1993-07-08 | Ligand to TNF 75P receptor and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2171404T3 true ES2171404T3 (es) | 2002-09-16 |
ES2171404T5 ES2171404T5 (es) | 2008-09-01 |
Family
ID=26322501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93114141T Expired - Lifetime ES2171404T5 (es) | 1992-09-03 | 1993-09-03 | Ligandos del tnf. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0585939B2 (es) |
JP (3) | JP4044970B2 (es) |
AT (1) | ATE212666T1 (es) |
AU (1) | AU678369B2 (es) |
CA (1) | CA2105534C (es) |
DE (1) | DE69331510T3 (es) |
DK (1) | DK0585939T4 (es) |
ES (1) | ES2171404T5 (es) |
IL (1) | IL106271A (es) |
PT (1) | PT585939E (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL107267A (en) * | 1993-10-12 | 2009-07-20 | Yeda Res & Dev | Ligand to a member of the tnf/ngf receptor family |
US5849501A (en) * | 1994-10-19 | 1998-12-15 | Genetics Institute, Inc. | TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding |
US5712381A (en) * | 1994-10-19 | 1998-01-27 | Genetics Institute, Inc. | MADD, a TNF receptor death domain ligand protein |
US5852173A (en) * | 1994-10-19 | 1998-12-22 | Genetics Institute, Inc. | TNF receptor death ligand proteins and inhibitors of ligand binding |
US5847099A (en) * | 1994-10-19 | 1998-12-08 | Genetics Institute, Inc. | TNF receptor death domain ligand proteins |
US6599719B2 (en) | 1994-11-07 | 2003-07-29 | Human Genome Sciences, Inc. | Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha |
US6824767B2 (en) | 1994-11-07 | 2004-11-30 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
US8110659B1 (en) | 1995-03-15 | 2012-02-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like genes |
US7094564B1 (en) | 1995-03-15 | 2006-08-22 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
US7078493B1 (en) | 1995-03-15 | 2006-07-18 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like genes |
US7427492B1 (en) | 1995-06-05 | 2008-09-23 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor receptor-like2 |
US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
IL139574A0 (en) * | 1998-05-18 | 2002-02-10 | Applied Research Systems | TNF-RII (p75) AGONISTS FOR TREATING ASTHMA AND OTHER ALLERGIC CONDITIONS |
US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
WO2004012673A2 (en) * | 2002-08-01 | 2004-02-12 | Wyeth, | Methods and reagents relating to inflammation and apoptosis |
IL158287A0 (en) | 2003-10-07 | 2004-05-12 | Yeda Res & Dev | Antibodies to nik, their preparation and use |
KR20120133403A (ko) | 2004-06-01 | 2012-12-10 | 도만티스 리미티드 | 증강된 혈청 반감기를 가지는 이특이성 융합 항체 |
US9534044B2 (en) * | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU636608B2 (en) * | 1989-05-18 | 1993-05-06 | Yeda Research And Development Co. Ltd. | Tumor necrosis factor binding protein II, it's purification and antibodies thereto |
DE4006269A1 (de) * | 1990-02-28 | 1991-08-29 | Max Planck Gesellschaft | Antikoerper gegen den tumor-nekrosefaktor-rezeptor |
-
1993
- 1993-07-08 IL IL106271A patent/IL106271A/en not_active IP Right Cessation
- 1993-09-03 ES ES93114141T patent/ES2171404T5/es not_active Expired - Lifetime
- 1993-09-03 DE DE69331510T patent/DE69331510T3/de not_active Expired - Lifetime
- 1993-09-03 AU AU46127/93A patent/AU678369B2/en not_active Expired
- 1993-09-03 AT AT93114141T patent/ATE212666T1/de active
- 1993-09-03 JP JP25465893A patent/JP4044970B2/ja not_active Expired - Lifetime
- 1993-09-03 CA CA002105534A patent/CA2105534C/en not_active Expired - Lifetime
- 1993-09-03 EP EP93114141A patent/EP0585939B2/en not_active Expired - Lifetime
- 1993-09-03 DK DK93114141T patent/DK0585939T4/da active
- 1993-09-03 PT PT93114141T patent/PT585939E/pt unknown
-
2004
- 2004-04-22 JP JP2004126924A patent/JP2004254703A/ja active Pending
-
2005
- 2005-08-15 JP JP2005235253A patent/JP2006014742A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT585939E (pt) | 2002-06-28 |
JP4044970B2 (ja) | 2008-02-06 |
DK0585939T3 (da) | 2002-05-06 |
JP2004254703A (ja) | 2004-09-16 |
AU4612793A (en) | 1994-03-10 |
CA2105534A1 (en) | 1994-03-04 |
EP0585939B1 (en) | 2002-01-30 |
EP0585939A2 (en) | 1994-03-09 |
ES2171404T5 (es) | 2008-09-01 |
IL106271A (en) | 2008-03-20 |
DK0585939T4 (da) | 2008-07-21 |
DE69331510T3 (de) | 2008-11-06 |
AU678369B2 (en) | 1997-05-29 |
ATE212666T1 (de) | 2002-02-15 |
IL106271A0 (en) | 1993-11-15 |
DE69331510D1 (de) | 2002-03-14 |
JPH06315394A (ja) | 1994-11-15 |
CA2105534C (en) | 2009-01-13 |
EP0585939A3 (en) | 1995-04-05 |
DE69331510T2 (de) | 2002-08-29 |
JP2006014742A (ja) | 2006-01-19 |
EP0585939B2 (en) | 2008-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2171404T3 (es) | Ligandos del fnt. | |
ATE44528T1 (de) | Arzneimittel mit antipsychotischer wirkung. | |
ES2071334T3 (es) | Analogos de anillos fusionados de nitrogeno conteniendo heterociclos no aromaticos. | |
ES2017820A6 (es) | Procedimiento de preparacion de un derivado de carboxamida. | |
ATE127341T1 (de) | Neue verwendung von modafinil. | |
GR3032611T3 (en) | Imidazoquinoxalinones, their aza analogs and process for their preparation. | |
OA09016A (fr) | Produits cathartiques. | |
DK238588A (da) | Anvendelse af 3-(trifluormethylphenoxy)-n-methyl-3-phenylpropylamin til fremstilling af et laegemiddel til behandling af diabetes | |
ES2086065T3 (es) | Preparacion de tetrahidropiridinas sustituidas. | |
UA19150A (uk) | Спосіб одержаhhя оптичhо активhого (+)-4-деметоксидауhоміциhоhу | |
IT8420358A0 (it) | Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti. | |
ES452290A1 (es) | Procedimiento para la preparacion de 1,4-bis (azolil-(2)- naftalina. | |
ES2021515A6 (es) | Procedimiento para la preparacion de compuestos derivados de isotiazolo-piridona azetidinil substituidos. | |
DK0487319T3 (da) | Hidtil ukendt heptamethylindanforbindelse | |
ES2041679T3 (es) | Compuestos analgesicos de octohidroindolizinas 5-substituidas y productos intermedios 7-ceto. | |
ES2012695A6 (es) | Un procedimiento para la preparacion de 4-(6'-metoxi -2'- naftil)-but-3-en -2-ona. | |
DE3470312D1 (de) | Ether of n-propanolamine derivative | |
IE872578L (en) | Antigestagen compositions | |
ES2027507A6 (es) | Procedimiento de preparacion de derivados selenofenicos. | |
FR2449680A1 (fr) | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant | |
ES8500925A1 (es) | "procedimiento para la preparacion de n-(2-(((5-(dimetilamino)-metil-2-furanil) metil) tio) etil) -n'- metil-2-nitro 1,1-etenodiamina" | |
ATE129151T1 (de) | Hypotriglyceridämische verwendung von bis(3,5-di- alkyl-4-hydroxyphenylthio)methanen. | |
ATE119779T1 (de) | Verwendung von 5'-vinylhalo- aristeromycin/adenosin-analoga als immunsuppressiva. | |
FR2677651B1 (fr) | Propenals substitues par un cycle dithiane et procede de preparation de ces propenals. | |
DE3469358D1 (en) | Novel 3-(4'-aminobutylamino)-propylamino-bleomycin derivatives, a process for their preparation and their use as medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 585939 Country of ref document: ES |