DK0576232T3 - Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer - Google Patents

Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer

Info

Publication number
DK0576232T3
DK0576232T3 DK93304821.7T DK93304821T DK0576232T3 DK 0576232 T3 DK0576232 T3 DK 0576232T3 DK 93304821 T DK93304821 T DK 93304821T DK 0576232 T3 DK0576232 T3 DK 0576232T3
Authority
DK
Denmark
Prior art keywords
deoxy
difluoro
ribofyranosylalkyl
separation
sulfon atoms
Prior art date
Application number
DK93304821.7T
Other languages
Danish (da)
English (en)
Inventor
Ta-Sen Chou
Timothy James Mccarthy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0576232T3 publication Critical patent/DK0576232T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK93304821.7T 1992-06-22 1993-06-21 Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer DK0576232T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
DK0576232T3 true DK0576232T3 (da) 1997-07-21

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93304821.7T DK0576232T3 (da) 1992-06-22 1993-06-21 Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer

Country Status (16)

Country Link
US (1) US5256797A (enExample)
EP (1) EP0576232B1 (enExample)
JP (1) JPH0656867A (enExample)
KR (1) KR100302087B1 (enExample)
AT (1) ATE149505T1 (enExample)
BR (1) BR9302426A (enExample)
CA (1) CA2098888C (enExample)
CY (1) CY2091B1 (enExample)
DE (1) DE69308391T2 (enExample)
DK (1) DK0576232T3 (enExample)
ES (1) ES2100462T3 (enExample)
GR (1) GR3023060T3 (enExample)
HU (1) HU217976B (enExample)
IL (1) IL106074A (enExample)
MX (1) MX9303714A (enExample)
TW (1) TW233300B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU214030B (en) * 1992-06-22 1997-12-29 Lilly Co Eli Process for preparing alpha-anomer enriched 1-halogen-2-deoxy-2,2-difluoro-d-ribofuranosyl derivatives
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
AP2005003213A0 (en) 2002-06-28 2005-03-31 Univ Cagliari 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
MXPA05006230A (es) 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
AU2005256963A1 (en) * 2004-06-23 2006-01-05 Centre National De La Recherche Scientifique 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
KR20080099263A (ko) * 2006-02-07 2008-11-12 케마지스 리미티드 젬시타빈 및 관련된 중간체의 제조 방법
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) * 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
CA1324128C (en) * 1987-08-28 1993-11-09 Ta-Sen Chou 2', 2'-difluoronucleosides

Also Published As

Publication number Publication date
HUT64551A (en) 1994-01-28
US5256797A (en) 1993-10-26
KR940000473A (ko) 1994-01-03
JPH0656867A (ja) 1994-03-01
CA2098888A1 (en) 1993-12-23
DE69308391T2 (de) 1997-07-17
IL106074A (en) 1998-02-22
ES2100462T3 (es) 1997-06-16
CA2098888C (en) 2003-07-29
KR100302087B1 (ko) 2001-10-22
EP0576232B1 (en) 1997-03-05
IL106074A0 (en) 1993-10-20
ATE149505T1 (de) 1997-03-15
HU217976B (hu) 2000-05-28
EP0576232A1 (en) 1993-12-29
CY2091B1 (en) 2002-04-05
MX9303714A (es) 1994-01-31
BR9302426A (pt) 1994-01-11
HK1006022A1 (en) 1999-02-05
GR3023060T3 (en) 1997-07-30
DE69308391D1 (de) 1997-04-10
HU9301826D0 (en) 1993-09-28
TW233300B (enExample) 1994-11-01

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