BR9302426A - Processo para a separacao de uma mistura anomerica - Google Patents

Processo para a separacao de uma mistura anomerica

Info

Publication number
BR9302426A
BR9302426A BR9302426A BR9302426A BR9302426A BR 9302426 A BR9302426 A BR 9302426A BR 9302426 A BR9302426 A BR 9302426A BR 9302426 A BR9302426 A BR 9302426A BR 9302426 A BR9302426 A BR 9302426A
Authority
BR
Brazil
Prior art keywords
separating
anomeric mixture
anomeric
mixture
countersolvent
Prior art date
Application number
BR9302426A
Other languages
English (en)
Portuguese (pt)
Inventor
Ta-Sen Chou
Timothy James Mccarthy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9302426A publication Critical patent/BR9302426A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR9302426A 1992-06-22 1993-06-21 Processo para a separacao de uma mistura anomerica BR9302426A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
BR9302426A true BR9302426A (pt) 1994-01-11

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9302426A BR9302426A (pt) 1992-06-22 1993-06-21 Processo para a separacao de uma mistura anomerica

Country Status (16)

Country Link
US (1) US5256797A (enExample)
EP (1) EP0576232B1 (enExample)
JP (1) JPH0656867A (enExample)
KR (1) KR100302087B1 (enExample)
AT (1) ATE149505T1 (enExample)
BR (1) BR9302426A (enExample)
CA (1) CA2098888C (enExample)
CY (1) CY2091B1 (enExample)
DE (1) DE69308391T2 (enExample)
DK (1) DK0576232T3 (enExample)
ES (1) ES2100462T3 (enExample)
GR (1) GR3023060T3 (enExample)
HU (1) HU217976B (enExample)
IL (1) IL106074A (enExample)
MX (1) MX9303714A (enExample)
TW (1) TW233300B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU214030B (en) * 1992-06-22 1997-12-29 Lilly Co Eli Process for preparing alpha-anomer enriched 1-halogen-2-deoxy-2,2-difluoro-d-ribofuranosyl derivatives
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
AP2005003213A0 (en) 2002-06-28 2005-03-31 Univ Cagliari 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
MXPA05006230A (es) 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
AU2005256963A1 (en) * 2004-06-23 2006-01-05 Centre National De La Recherche Scientifique 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
KR20080099263A (ko) * 2006-02-07 2008-11-12 케마지스 리미티드 젬시타빈 및 관련된 중간체의 제조 방법
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) * 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
CA1324128C (en) * 1987-08-28 1993-11-09 Ta-Sen Chou 2', 2'-difluoronucleosides

Also Published As

Publication number Publication date
HUT64551A (en) 1994-01-28
US5256797A (en) 1993-10-26
KR940000473A (ko) 1994-01-03
JPH0656867A (ja) 1994-03-01
CA2098888A1 (en) 1993-12-23
DE69308391T2 (de) 1997-07-17
IL106074A (en) 1998-02-22
ES2100462T3 (es) 1997-06-16
CA2098888C (en) 2003-07-29
KR100302087B1 (ko) 2001-10-22
EP0576232B1 (en) 1997-03-05
IL106074A0 (en) 1993-10-20
ATE149505T1 (de) 1997-03-15
HU217976B (hu) 2000-05-28
EP0576232A1 (en) 1993-12-29
CY2091B1 (en) 2002-04-05
MX9303714A (es) 1994-01-31
HK1006022A1 (en) 1999-02-05
DK0576232T3 (da) 1997-07-21
GR3023060T3 (en) 1997-07-30
DE69308391D1 (de) 1997-04-10
HU9301826D0 (en) 1993-09-28
TW233300B (enExample) 1994-11-01

Similar Documents

Publication Publication Date Title
BR9302426A (pt) Processo para a separacao de uma mistura anomerica
BR9302428A (pt) Processo estereosseletivo a baixa temperatura para preparar um derivado enriquecido de riboturanosila alfa-anomero e o derivado obitdo
BR9303658A (pt) Processo para aumentar a quantidade de nucleosideo de beta-anomero
ATE114651T1 (de) Alkynylamino-nukleotide.
BR9205681A (pt) Processo multi-estágio para produção de negro-de-fumo
BR8501408A (pt) Composicao de revestimento liquida
BR9005296A (pt) Processo para a hidroformilacao de uma olefina
ES548152A0 (es) Procedimiento para preparar un compuesto seleccionado del grupo constituido de 7-halo-7-desoxilincomicina y analogos de la misma
BR8108652A (pt) Processo e dispositivo para composicao datilografica,de numeros e de sinais
PT94559A (pt) Processo para a preparacao de uma sonda de acido nucleico hidrofobica
ES2103433T3 (es) Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa.
ES2020225B3 (es) Aparato de enfriamiento rapido regulable para templar laminas de vidrio caliente.
ES2011810B3 (es) Dispositivo para el temple de laminas de vidrio.
BR7805353A (pt) Processo,aparelho e sistema para aquecimento de material com circulacao de gas
IT1034702B (it) Processo per la carbossilazione di substrati organici con anidri de carbonica.
BR8701749A (pt) Processo e disposicao de circuito para o comando de uma valvula de injecao
ES271050Y (es) Instalacion para el secado y precalentamiento de carbon de coque.
PT90837A (pt) Processo e sistema de vigilancia das falhas de, pelo menos, uma fonte luminosa
BR8702800A (pt) Processo para fabricacao de acendedor,acendedor e pluraridade de acendedores
BR8606481A (pt) Aparelhagem para o aquecimento de material,especialmente para a liquefacao de uma batelada de vidro
PT89667A (pt) Processo para a modificacao de um crivo molecular
BR8903073A (pt) Processo para preparacao de alcanos fluorados
ES2127249T3 (es) Procedimiento para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil-arilsulfonatos enriquecidos en el anomero beta.
BR9304873A (pt) Método para aperfeiçoar um processo enzimático, utilizando pelo menos uma enzima que apresenta atividade pectinase.
ATE177090T1 (de) Glycidylderivate von 2,6-dibromo-3,5-dialkyl-4- hydroxybenzylethern

Legal Events

Date Code Title Description
EE Request for examination
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
CKFC Appeal: appeal against refusal