TW233300B - - Google Patents

Info

Publication number
TW233300B
TW233300B TW082104993A TW82104993A TW233300B TW 233300 B TW233300 B TW 233300B TW 082104993 A TW082104993 A TW 082104993A TW 82104993 A TW82104993 A TW 82104993A TW 233300 B TW233300 B TW 233300B
Authority
TW
Taiwan
Prior art keywords
anomeric mixture
countersolvent
ribofuranosyl
alkylsulfonates
deoxy
Prior art date
Application number
TW082104993A
Other languages
English (en)
Chinese (zh)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of TW233300B publication Critical patent/TW233300B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW082104993A 1992-06-22 1993-06-22 TW233300B (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
TW233300B true TW233300B (enExample) 1994-11-01

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082104993A TW233300B (enExample) 1992-06-22 1993-06-22

Country Status (16)

Country Link
US (1) US5256797A (enExample)
EP (1) EP0576232B1 (enExample)
JP (1) JPH0656867A (enExample)
KR (1) KR100302087B1 (enExample)
AT (1) ATE149505T1 (enExample)
BR (1) BR9302426A (enExample)
CA (1) CA2098888C (enExample)
CY (1) CY2091B1 (enExample)
DE (1) DE69308391T2 (enExample)
DK (1) DK0576232T3 (enExample)
ES (1) ES2100462T3 (enExample)
GR (1) GR3023060T3 (enExample)
HU (1) HU217976B (enExample)
IL (1) IL106074A (enExample)
MX (1) MX9303714A (enExample)
TW (1) TW233300B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103433T3 (es) * 1992-06-22 1997-09-16 Lilly Co Eli Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa.
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1294735A2 (en) 2000-05-26 2003-03-26 Novirio Pharmaceuticals Limited Methods and compositions for treating flaviviruses and pestiviruses
CA2489552A1 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
PL377287A1 (pl) 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
EP1912643A2 (en) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
WO2007092705A2 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
ATE217009T1 (de) * 1987-08-28 2002-05-15 Lilly Co Eli Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen

Also Published As

Publication number Publication date
HUT64551A (en) 1994-01-28
KR940000473A (ko) 1994-01-03
ATE149505T1 (de) 1997-03-15
HU9301826D0 (en) 1993-09-28
CA2098888C (en) 2003-07-29
HU217976B (hu) 2000-05-28
DK0576232T3 (da) 1997-07-21
MX9303714A (es) 1994-01-31
IL106074A0 (en) 1993-10-20
KR100302087B1 (ko) 2001-10-22
GR3023060T3 (en) 1997-07-30
DE69308391D1 (de) 1997-04-10
JPH0656867A (ja) 1994-03-01
BR9302426A (pt) 1994-01-11
CY2091B1 (en) 2002-04-05
HK1006022A1 (en) 1999-02-05
DE69308391T2 (de) 1997-07-17
ES2100462T3 (es) 1997-06-16
EP0576232B1 (en) 1997-03-05
IL106074A (en) 1998-02-22
CA2098888A1 (en) 1993-12-23
US5256797A (en) 1993-10-26
EP0576232A1 (en) 1993-12-29

Similar Documents

Publication Publication Date Title
TW233300B (enExample)
AU5684994A (en) Thermal cracking process with reduced coking
OA09069A (en) Thermal decomposition furnace.
HU9301822D0 (en) A stereoselective glycosyling procedure
HU9302452D0 (en) Method for anomerizating nucleosides
TW233299B (enExample)
HUT40806A (en) Process for preparing 7-halo-7-deoxy-lincomycines
EP0152597A3 (en) Apparatus for emitting an receiving light signals, more particularly infrared signals
HUT44996A (en) Process for producing vinyl-chloride with cleaving 1,2-dichloro-ethan with heat
EP0317054A3 (en) Low temperature gas chromatography apparatus
EP0223199A3 (en) Process for producing high-strenght, high-modulus carbon fibers
ZA81383B (en) Process for the thermal tempering of glass
KR960007423B1 (en) Apparatus for injecting gas into high temperature liquids e.g.molten metal
DE3560644D1 (en) Heater assembly for molecular beam epitaxy furnace
GR3031149T3 (en) Process for the manufacture of (s)-3-amino-1-substituted-pyrrolidines.
ZA898001B (en) Removing hydrogen sulphide from a gas mixture
AU530777B2 (en) Text search apparatus for typewriters
AU587564B2 (en) Heating apparatus for drawing glass rod
EP0614928A3 (en) Process for the preparation of copolymers from carbon monoxide and ethylenically unsaturated compounds.
GB8403603D0 (en) High temperature pyrolysis process
DE3568420D1 (en) Process for the pretreatment of 1,2-dichloroethane before its pyrolysis

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees