DK0576232T3 - Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer - Google Patents
Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomererInfo
- Publication number
- DK0576232T3 DK0576232T3 DK93304821.7T DK93304821T DK0576232T3 DK 0576232 T3 DK0576232 T3 DK 0576232T3 DK 93304821 T DK93304821 T DK 93304821T DK 0576232 T3 DK0576232 T3 DK 0576232T3
- Authority
- DK
- Denmark
- Prior art keywords
- deoxy
- difluoro
- ribofyranosylalkyl
- separation
- sulfon atoms
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/902,303 US5256797A (en) | 1992-06-22 | 1992-06-22 | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0576232T3 true DK0576232T3 (da) | 1997-07-21 |
Family
ID=25415647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93304821.7T DK0576232T3 (da) | 1992-06-22 | 1993-06-21 | Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer |
Country Status (17)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69311000T2 (de) * | 1992-06-22 | 1997-11-27 | Lilly Co Eli | Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EA007867B1 (ru) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения |
| MXPA04012802A (es) | 2002-06-28 | 2005-04-19 | Idenix Cayman Ltd | Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae. |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| RU2005118421A (ru) | 2002-11-15 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | 2'-разветвленные нуклеозиды и мутация flaviviridae |
| PL377287A1 (pl) | 2002-12-12 | 2006-01-23 | Idenix (Cayman) Limited | Sposób wytwarzania 2'-rozgałęzionych nukleozydów |
| JP2008503562A (ja) * | 2004-06-23 | 2008-02-07 | イデニクス（ケイマン）リミテツド | フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体 |
| US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
| AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
| US7781576B2 (en) | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| WO2007092705A2 (en) * | 2006-02-07 | 2007-08-16 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
| GB0812895D0 (en) * | 2008-07-15 | 2008-08-20 | Glycom As | Crystalline carbohydrate derivative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| IL87517A (en) * | 1987-08-28 | 1993-05-13 | Lilly Co Eli | Process for preparing an enantiomeric mixture of erythro and threo lactones |
-
1992
- 1992-06-22 US US07/902,303 patent/US5256797A/en not_active Expired - Lifetime
-
1993
- 1993-06-21 ES ES93304821T patent/ES2100462T3/es not_active Expired - Lifetime
- 1993-06-21 EP EP93304821A patent/EP0576232B1/en not_active Expired - Lifetime
- 1993-06-21 KR KR1019930011306A patent/KR100302087B1/ko not_active Expired - Fee Related
- 1993-06-21 CA CA002098888A patent/CA2098888C/en not_active Expired - Lifetime
- 1993-06-21 DE DE69308391T patent/DE69308391T2/de not_active Expired - Lifetime
- 1993-06-21 BR BR9302426A patent/BR9302426A/pt not_active Application Discontinuation
- 1993-06-21 AT AT93304821T patent/ATE149505T1/de active
- 1993-06-21 HU HU9301826A patent/HU217976B/hu not_active IP Right Cessation
- 1993-06-21 MX MX9303714A patent/MX9303714A/es unknown
- 1993-06-21 IL IL106074A patent/IL106074A/en not_active IP Right Cessation
- 1993-06-21 JP JP5149152A patent/JPH0656867A/ja active Pending
- 1993-06-21 DK DK93304821.7T patent/DK0576232T3/da active
- 1993-06-22 TW TW082104993A patent/TW233300B/zh not_active IP Right Cessation
-
1997
- 1997-04-08 GR GR970400728T patent/GR3023060T3/el unknown
-
1998
- 1998-06-12 HK HK98105211A patent/HK1006022A1/en not_active IP Right Cessation
- 1998-06-18 CY CY9800012A patent/CY2091B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69308391D1 (de) | 1997-04-10 |
| IL106074A0 (en) | 1993-10-20 |
| BR9302426A (pt) | 1994-01-11 |
| KR940000473A (ko) | 1994-01-03 |
| GR3023060T3 (en) | 1997-07-30 |
| MX9303714A (es) | 1994-01-31 |
| ATE149505T1 (de) | 1997-03-15 |
| HU9301826D0 (en) | 1993-09-28 |
| EP0576232B1 (en) | 1997-03-05 |
| DE69308391T2 (de) | 1997-07-17 |
| CY2091B1 (en) | 2002-04-05 |
| KR100302087B1 (ko) | 2001-10-22 |
| CA2098888C (en) | 2003-07-29 |
| ES2100462T3 (es) | 1997-06-16 |
| IL106074A (en) | 1998-02-22 |
| HUT64551A (en) | 1994-01-28 |
| JPH0656867A (ja) | 1994-03-01 |
| HK1006022A1 (en) | 1999-02-05 |
| HU217976B (hu) | 2000-05-28 |
| CA2098888A1 (en) | 1993-12-23 |
| EP0576232A1 (en) | 1993-12-29 |
| TW233300B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-11-01 |
| US5256797A (en) | 1993-10-26 |
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