DK0576229T3 - Lavtemperatur fremgangsmåde til fremstilling af alphaanomerberigede 2-deoxy-2,2-difluor-D-ribofuranosylsulfonater - Google Patents

Lavtemperatur fremgangsmåde til fremstilling af alphaanomerberigede 2-deoxy-2,2-difluor-D-ribofuranosylsulfonater

Info

Publication number
DK0576229T3
DK0576229T3 DK93304818.3T DK93304818T DK0576229T3 DK 0576229 T3 DK0576229 T3 DK 0576229T3 DK 93304818 T DK93304818 T DK 93304818T DK 0576229 T3 DK0576229 T3 DK 0576229T3
Authority
DK
Denmark
Prior art keywords
deoxy
difluoro
enriched
alphanomer
preparation
Prior art date
Application number
DK93304818.3T
Other languages
Danish (da)
English (en)
Inventor
Ta-Sen Chou
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25415642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0576229(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0576229T3 publication Critical patent/DK0576229T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK93304818.3T 1992-06-22 1993-06-21 Lavtemperatur fremgangsmåde til fremstilling af alphaanomerberigede 2-deoxy-2,2-difluor-D-ribofuranosylsulfonater DK0576229T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,301 US5401861A (en) 1992-06-22 1992-06-22 Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Publications (1)

Publication Number Publication Date
DK0576229T3 true DK0576229T3 (da) 1998-01-19

Family

ID=25415642

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93304818.3T DK0576229T3 (da) 1992-06-22 1993-06-21 Lavtemperatur fremgangsmåde til fremstilling af alphaanomerberigede 2-deoxy-2,2-difluor-D-ribofuranosylsulfonater

Country Status (15)

Country Link
US (1) US5401861A (cs)
EP (1) EP0576229B1 (cs)
JP (1) JP3379994B2 (cs)
KR (1) KR100312389B1 (cs)
AT (1) ATE161264T1 (cs)
BR (1) BR9302428A (cs)
CA (1) CA2098886C (cs)
DE (1) DE69315752T2 (cs)
DK (1) DK0576229T3 (cs)
ES (1) ES2112389T3 (cs)
GR (1) GR3026210T3 (cs)
HU (1) HU216840B (cs)
IL (1) IL106076A (cs)
MX (1) MX9303710A (cs)
TW (1) TW233299B (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
PL359169A1 (en) 2000-05-26 2004-08-23 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004002422A2 (en) * 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
DK1576138T3 (en) 2002-11-15 2017-05-01 Idenix Pharmaceuticals Llc 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION
CA2509687C (en) * 2002-12-12 2012-08-14 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
CA2571675A1 (en) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
KR100699099B1 (ko) * 2004-07-29 2007-03-22 한미약품 주식회사 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
CA2574954C (en) 2004-07-29 2010-04-20 Hanmi Pharm. Co., Ltd. 1-.alpha.-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and process for the preparation thereof
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
BRPI0514718A (pt) * 2004-12-30 2008-07-01 Hanmi Pharm Ind Co Ltd método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina
ES2341663T3 (es) * 2005-03-04 2010-06-24 Fresenius Kabi Oncology Limited Intermedio y procedimiento para preparar 2'-desoxi-2',2'-difluoro-d-ribofuranosil nucleosidos enriquecidos en el anomero beta.
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
MX2007015174A (es) * 2005-06-03 2008-04-22 Scinopharm Taiwan Ltd Proceso para elaborar un sulfonato de 2-desoxi-2,2-difluoro-d-ribo furanosilo enriquecido con alfa-anomero y su uso para elaborar beta nucleosido.
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
ES2422290T3 (es) * 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
KR101357409B1 (ko) 2006-11-03 2014-02-03 에스티팜 주식회사 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법
KR100858842B1 (ko) 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
US7994310B2 (en) * 2007-03-23 2011-08-09 Dongwoo Syntech Co., Ltd. Process for preparing 2′-deoxy-2′, 2′-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
IL87517A (en) * 1987-08-28 1993-05-13 Lilly Co Eli Process for preparing an enantiomeric mixture of erythro and threo lactones

Also Published As

Publication number Publication date
TW233299B (cs) 1994-11-01
KR100312389B1 (ko) 2002-06-20
GR3026210T3 (en) 1998-05-29
HUT64552A (en) 1994-01-28
ATE161264T1 (de) 1998-01-15
IL106076A0 (en) 1993-10-20
JP3379994B2 (ja) 2003-02-24
EP0576229B1 (en) 1997-12-17
HU216840B (hu) 1999-09-28
KR940005655A (ko) 1994-03-22
US5401861A (en) 1995-03-28
BR9302428A (pt) 1994-01-11
DE69315752D1 (de) 1998-01-29
CA2098886C (en) 2005-08-09
HU9301827D0 (en) 1993-09-28
MX9303710A (es) 1994-01-31
CA2098886A1 (en) 1993-12-23
DE69315752T2 (de) 1998-04-23
EP0576229A1 (en) 1993-12-29
JPH0656866A (ja) 1994-03-01
IL106076A (en) 2002-02-10
ES2112389T3 (es) 1998-04-01

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