DK0567982T3 - Azolforbindelser, deres fremstilling og anvendelse - Google Patents

Azolforbindelser, deres fremstilling og anvendelse

Info

Publication number
DK0567982T3
DK0567982T3 DK93106772T DK93106772T DK0567982T3 DK 0567982 T3 DK0567982 T3 DK 0567982T3 DK 93106772 T DK93106772 T DK 93106772T DK 93106772 T DK93106772 T DK 93106772T DK 0567982 T3 DK0567982 T3 DK 0567982T3
Authority
DK
Denmark
Prior art keywords
group
independently
preparation
lower alkyl
atom
Prior art date
Application number
DK93106772T
Other languages
Danish (da)
English (en)
Inventor
Katsumi Itoh
Norikazu Tamura
Kenji Okonogi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DK0567982T3 publication Critical patent/DK0567982T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerization Catalysts (AREA)
  • Coloring (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK93106772T 1992-04-28 1993-04-27 Azolforbindelser, deres fremstilling og anvendelse DK0567982T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11040092 1992-04-28
JP2262393 1993-02-10

Publications (1)

Publication Number Publication Date
DK0567982T3 true DK0567982T3 (da) 1999-04-12

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93106772T DK0567982T3 (da) 1992-04-28 1993-04-27 Azolforbindelser, deres fremstilling og anvendelse

Country Status (18)

Country Link
US (2) US5371101A (no)
EP (1) EP0567982B1 (no)
JP (1) JP2818097B2 (no)
KR (1) KR100257619B1 (no)
CN (1) CN1040433C (no)
AT (1) ATE167857T1 (no)
AU (1) AU655544B2 (no)
CA (1) CA2094962A1 (no)
DE (1) DE69319380T2 (no)
DK (1) DK0567982T3 (no)
ES (1) ES2118160T3 (no)
FI (1) FI931901A (no)
HU (2) HUT64327A (no)
NO (1) NO303284B1 (no)
NZ (1) NZ247488A (no)
PH (1) PH31082A (no)
SG (1) SG48939A1 (no)
TW (1) TW218017B (no)

Families Citing this family (52)

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HU212458B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them
TW297813B (no) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
US5814324A (en) * 1994-02-25 1998-09-29 Takeda Chemical Industries, Ltd. Injectable composition and a method of producing the same
CA2150533A1 (en) * 1994-05-31 1995-12-01 Katsumi Itoh Production of optically active triazole compounds and their intermediates
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
TW318841B (no) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
WO1996025410A1 (en) * 1995-02-17 1996-08-22 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
BR9606546A (pt) * 1995-08-02 1998-07-14 Uriach & Cia Sa J Novas carboxamidas com atividade fungicida
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
EP0783501B9 (en) * 1995-08-02 2001-07-25 J. URIACH & CIA. S.A. pyrimidone derivatives with antifungal activity
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU715603B2 (en) * 1996-04-03 2000-02-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1998039305A1 (en) * 1997-03-05 1998-09-11 Takeda Chemical Industries, Ltd. Crystalline form of a bis 1,2,4-triazole compound
WO1998043970A1 (en) * 1997-03-31 1998-10-08 Takeda Chemical Industries, Ltd. Azole compounds, their production and their use
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
US6583164B1 (en) 1998-09-29 2003-06-24 Takeda Chemical Industries, Ltd. Antimycotic drug composition
NZ521241A (en) * 2000-03-07 2004-02-27 Ranbaxy Lab Ltd Azole compounds as therapeutic agents for fungal infections
IN191188B (no) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
ES2159488B1 (es) * 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
HUP0400725A2 (hu) * 2000-12-26 2004-07-28 Ranbaxy Laboratories Limited Szubsztituált 1,2,4-tiazol-3(2H,4H)-tion-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyászati készítmények
ATE309226T1 (de) * 2001-03-23 2005-11-15 Richter Gedeon Vegyeszet Verfahren zur herstellung von fluconazole und kristallmodifikationen davon
IN191819B (no) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
IN192526B (no) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
MXPA04010066A (es) * 2002-04-12 2004-12-13 Ranbaxy Lab Ltd Derivados de tetrahidrofurano 2,2,4-trisubstituido como agentes antifungicos.
ATE521349T1 (de) 2002-06-18 2011-09-15 Pola Pharma Inc Antimykotische medizinische zusammensetzungen
AU2002328176A1 (en) * 2002-08-26 2004-03-11 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
CN103554042B (zh) 2004-11-18 2016-08-10 Synta医药公司 调节hsp90活性的三唑化合物
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
WO2007021966A1 (en) * 2005-08-12 2007-02-22 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate hsp90 activity
TWI446910B (zh) * 2005-08-18 2014-08-01 Synta Pharmaceuticals Corp 調節ｈｓｐ９０活性的三唑化合物
SI2035396T1 (sl) * 2006-05-25 2014-08-29 Synta Pharmaceuticals Corp. Triazolne spojine, ki modulirajo aktivnost HSP90
EP2034996A2 (en) * 2006-05-25 2009-03-18 Synta Pharmaceuticals Corporation Triazole compounds that modulate hsp90 activity
US20080027047A1 (en) * 2006-05-25 2008-01-31 Weiwen Ying Compounds that modulate HSP90 activity and methods for identifying same
EP2038262B1 (en) * 2006-05-25 2014-11-12 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
BRPI0716026A2 (pt) 2006-08-07 2013-08-06 Stiefel Laboratories compostos antiféngicos cristalinos
JP5079011B2 (ja) * 2006-10-19 2012-11-21 エフ．ホフマン−ラ ロシュ アーゲー 糖尿病のための１１β−ＨＳＤ１阻害剤としてのイミダゾロン及びイミダゾリジノン誘導体
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
WO2013067165A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
WO2013067162A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
EP2780010A1 (en) 2011-11-14 2014-09-24 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
FI97382C (fi) * 1988-03-04 1996-12-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten 1,2,4-triatsolijohdannaisten valmistamiseksi
DE3837463A1 (de) * 1988-11-04 1990-05-10 Bayer Ag Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
EP0567982A1 (en) 1993-11-03
JPH06293740A (ja) 1994-10-21
EP0567982B1 (en) 1998-07-01
KR100257619B1 (en) 2000-07-01
FI931901A (fi) 1993-10-29
AU3822193A (en) 1993-11-04
FI931901A0 (fi) 1993-04-27
ES2118160T3 (es) 1998-09-16
NO303284B1 (no) 1998-06-22
NZ247488A (en) 1995-02-24
DE69319380D1 (de) 1998-08-06
AU655544B2 (en) 1994-12-22
JP2818097B2 (ja) 1998-10-30
CN1079467A (zh) 1993-12-15
CA2094962A1 (en) 1993-10-29
HU211474A9 (en) 1995-11-28
ATE167857T1 (de) 1998-07-15
PH31082A (en) 1998-02-05
KR940005616A (ko) 1994-03-21
US5466820A (en) 1995-11-14
NO931533D0 (no) 1993-04-27
NO931533L (no) 1993-10-29
CN1040433C (zh) 1998-10-28
US5371101A (en) 1994-12-06
SG48939A1 (en) 1998-05-18
TW218017B (no) 1993-12-21
HUT64327A (en) 1993-12-28
DE69319380T2 (de) 1998-10-29
HU9301226D0 (en) 1993-07-28

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