DK0552817T3 - Milbemycinether-derivater, deres fremstilling og deres terapeutiske og agrokemiske anvendelse - Google Patents
Milbemycinether-derivater, deres fremstilling og deres terapeutiske og agrokemiske anvendelseInfo
- Publication number
- DK0552817T3 DK0552817T3 DK93105233T DK93105233T DK0552817T3 DK 0552817 T3 DK0552817 T3 DK 0552817T3 DK 93105233 T DK93105233 T DK 93105233T DK 93105233 T DK93105233 T DK 93105233T DK 0552817 T3 DK0552817 T3 DK 0552817T3
- Authority
- DK
- Denmark
- Prior art keywords
- opt
- substd
- halo
- cycloalkyl
- roco
- Prior art date
Links
- FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 title abstract 2
- 239000003905 agrochemical Substances 0.000 title 1
- 150000002170 ethers Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- -1 hydroxyimino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5076090 | 1990-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0552817T3 true DK0552817T3 (da) | 1999-01-25 |
Family
ID=12867790
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93105234.4T DK0552818T3 (da) | 1990-03-01 | 1991-03-01 | Milbemycinetherderivater, deres fremstilling og deres terapeutiske og agrokemiske anvendelser |
| DK93105233T DK0552817T3 (da) | 1990-03-01 | 1991-03-01 | Milbemycinether-derivater, deres fremstilling og deres terapeutiske og agrokemiske anvendelse |
| DK91301749.7T DK0448243T3 (da) | 1990-03-01 | 1991-03-01 | Milbemycinether-derivater, deres fremstilling og deres terapeutiske og agrokemiske anvendelse |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93105234.4T DK0552818T3 (da) | 1990-03-01 | 1991-03-01 | Milbemycinetherderivater, deres fremstilling og deres terapeutiske og agrokemiske anvendelser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91301749.7T DK0448243T3 (da) | 1990-03-01 | 1991-03-01 | Milbemycinether-derivater, deres fremstilling og deres terapeutiske og agrokemiske anvendelse |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5346918A (es) |
| EP (3) | EP0552818B1 (es) |
| JP (1) | JP2622197B2 (es) |
| KR (1) | KR0168848B1 (es) |
| AT (3) | ATE154357T1 (es) |
| AU (1) | AU634864B2 (es) |
| CA (1) | CA2037414A1 (es) |
| DE (3) | DE69129498T2 (es) |
| DK (3) | DK0552818T3 (es) |
| ES (3) | ES2117678T3 (es) |
| GR (2) | GR3019205T3 (es) |
| HK (3) | HK1005731A1 (es) |
| NZ (1) | NZ237276A (es) |
| ZA (1) | ZA911533B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202452B (es) * | 1989-12-01 | 1993-03-21 | Ciba Geigy Ag | |
| JPH085894B2 (ja) * | 1990-03-01 | 1996-01-24 | 三共株式会社 | ミルベマイシンエーテル誘導体 |
| US5276033A (en) * | 1991-12-18 | 1994-01-04 | Sankyo Company, Limited | 13-(substituted thio)acetoxymilbemycin derivatives, their preparation and their agrochemical uses |
| CA2105251C (en) * | 1992-09-01 | 2004-12-07 | Mitsugi Shibano | Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor |
| US5614470A (en) * | 1994-04-01 | 1997-03-25 | Sankyo Company, Limited | 13-substituted milbemycin derivatives, their preparation and their use |
| AU3935495A (en) * | 1994-11-24 | 1996-06-17 | Sankyo Company Limited | 13-etherified milbemycin derivative with insecticidal activity |
| GB0229804D0 (en) * | 2002-12-20 | 2003-01-29 | Syngenta Participations Ag | Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position |
| EP1849363A1 (en) * | 2006-03-09 | 2007-10-31 | Cheminova A/S | Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin |
| CA3079959A1 (en) * | 2017-10-27 | 2018-10-26 | Transfusion Health, Llc | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene |
| CN111217828B (zh) * | 2018-11-26 | 2022-11-25 | 浙江海正药业股份有限公司 | 一种乐平霉素的制备方法及其中间体 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| US4206205A (en) * | 1977-10-03 | 1980-06-03 | Merck & Co., Inc. | Monosaccharide and aglycone derivatives of C-076 |
| US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4201861A (en) * | 1977-10-03 | 1980-05-06 | Merck & Co., Inc. | Acyl derivatives of C-076 compounds |
| US4171314A (en) * | 1977-12-19 | 1979-10-16 | Merck & Co., Inc. | 13-Halo and 13-deoxy C-076 compounds |
| US4173571A (en) * | 1977-12-19 | 1979-11-06 | Merck & Co., Inc. | 13-Halo and 13-deoxy derivatives of C-076 compounds |
| US4203976A (en) * | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4200581A (en) * | 1978-08-04 | 1980-04-29 | Merck & Co., Inc. | Alkyl derivatives of C-076 compounds |
| JPS5632481A (en) * | 1979-08-23 | 1981-04-01 | Sankyo Co Ltd | Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent |
| US4315023A (en) * | 1979-09-06 | 1982-02-09 | Westwood Pharmaceuticals, Inc. | 1-Phenethylimidazole derivatives |
| US4289760A (en) * | 1980-05-02 | 1981-09-15 | Merck & Co., Inc. | 23-Keto derivatives of C-076 compounds |
| JPS57120589A (en) * | 1981-01-20 | 1982-07-27 | Sankyo Co Ltd | 5-methoxy and 5-lower alkanoyloxy derivative, its preparation and acaricide and parasiticide |
| JPS57190589A (en) * | 1981-05-19 | 1982-11-24 | Brother Ind Ltd | Sound displayable sewing machine |
| US4457920A (en) * | 1981-09-03 | 1984-07-03 | Merck & Co., Inc. | 4a-Substituted avermectin compounds |
| US4423209A (en) * | 1982-02-26 | 1983-12-27 | Merck & Co., Inc. | Processes for the interconversion of avermectin compounds |
| JPS5916894A (ja) * | 1982-07-21 | 1984-01-28 | Sankyo Co Ltd | ミルベマイシンｄの５−アシルオキシ誘導体 |
| JPS5920285A (ja) * | 1982-07-23 | 1984-02-01 | Sankyo Co Ltd | ミルベマイシンｄの５−二塩基酸エステル誘導体及びその塩 |
| JPS59108785A (ja) * | 1982-11-25 | 1984-06-23 | Sankyo Co Ltd | ミルベマイシン類の５−オキシム誘導体 |
| US4469682A (en) * | 1983-01-28 | 1984-09-04 | Merck & Co., Inc. | Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use |
| DK165119C (da) * | 1984-06-05 | 1993-03-01 | American Cyanamid Co | Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling |
| US4579864A (en) * | 1984-06-11 | 1986-04-01 | Merck & Co., Inc. | Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives |
| US4547491A (en) * | 1984-07-18 | 1985-10-15 | Merck & Co., Inc. | C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use |
| EP0180539A1 (de) * | 1984-09-18 | 1986-05-07 | Ciba-Geigy Ag | 13-Halo- und 13-Hydroximilbemycine |
| US4646541A (en) * | 1984-11-13 | 1987-03-03 | Columbia Gas System Service Corporation | Absorption refrigeration and heat pump system |
| US4696922A (en) * | 1984-11-26 | 1987-09-29 | Ciba-Geigy Corporation | 5-azolylacetoxymilbemycins as ecto- and endoparasites |
| HUT39739A (en) * | 1984-12-04 | 1986-10-29 | Ciba Geigy Ag | Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof |
| GB2168345B (en) * | 1984-12-14 | 1988-05-25 | Ciba Geigy Ag | Pesticidal 13b-substituted milbemycin derivatives |
| IL78621A (en) * | 1985-04-30 | 1991-06-30 | American Cyanamid Co | Mylbemycin analogs,their preparation and pesticidal compositions containing them |
| JPS6289685A (ja) * | 1985-05-31 | 1987-04-24 | Sankyo Co Ltd | １３−ハロゲンミルベマイシン誘導体 |
| CH669382A5 (en) * | 1986-05-21 | 1989-03-15 | Ciba Geigy Ag | 13-0-substd. milbemycin derivs. - with insecticidal, acaricidal, nematocidal and anthelmintic activity, prepd. by etherification of 13-0 unsubstituted cpds |
| AU613521B2 (en) * | 1988-09-02 | 1991-08-01 | Sankyo Company Limited | 13-substituted milbemycin derivatives, their preparation and use |
| US5015630A (en) * | 1989-01-19 | 1991-05-14 | Merck & Co., Inc. | 5-oxime avermectin derivatives |
| US5276033A (en) * | 1991-12-18 | 1994-01-04 | Sankyo Company, Limited | 13-(substituted thio)acetoxymilbemycin derivatives, their preparation and their agrochemical uses |
-
1991
- 1991-02-14 JP JP3020858A patent/JP2622197B2/ja not_active Expired - Lifetime
- 1991-02-27 US US07/661,833 patent/US5346918A/en not_active Expired - Fee Related
- 1991-02-28 KR KR1019910003395A patent/KR0168848B1/ko not_active IP Right Cessation
- 1991-03-01 ES ES93105233T patent/ES2117678T3/es not_active Expired - Lifetime
- 1991-03-01 DK DK93105234.4T patent/DK0552818T3/da active
- 1991-03-01 NZ NZ237276A patent/NZ237276A/xx unknown
- 1991-03-01 AT AT93105234T patent/ATE154357T1/de not_active IP Right Cessation
- 1991-03-01 ES ES93105234T patent/ES2104987T3/es not_active Expired - Lifetime
- 1991-03-01 AT AT93105233T patent/ATE166651T1/de not_active IP Right Cessation
- 1991-03-01 CA CA002037414A patent/CA2037414A1/en not_active Abandoned
- 1991-03-01 EP EP93105234A patent/EP0552818B1/en not_active Expired - Lifetime
- 1991-03-01 DK DK93105233T patent/DK0552817T3/da active
- 1991-03-01 DK DK91301749.7T patent/DK0448243T3/da active
- 1991-03-01 ES ES91301749T patent/ES2084767T3/es not_active Expired - Lifetime
- 1991-03-01 EP EP91301749A patent/EP0448243B1/en not_active Expired - Lifetime
- 1991-03-01 ZA ZA911533A patent/ZA911533B/xx unknown
- 1991-03-01 DE DE69129498T patent/DE69129498T2/de not_active Expired - Fee Related
- 1991-03-01 EP EP93105233A patent/EP0552817B1/en not_active Expired - Lifetime
- 1991-03-01 AU AU72026/91A patent/AU634864B2/en not_active Ceased
- 1991-03-01 DE DE69126534T patent/DE69126534T2/de not_active Expired - Fee Related
- 1991-03-01 DE DE69116403T patent/DE69116403T2/de not_active Expired - Fee Related
- 1991-03-01 AT AT91301749T patent/ATE133174T1/de active
-
1994
- 1994-07-11 US US08/273,240 patent/US5604182A/en not_active Expired - Fee Related
-
1996
- 1996-03-05 GR GR960400609T patent/GR3019205T3/el unknown
-
1997
- 1997-08-26 GR GR970402182T patent/GR3024542T3/el unknown
-
1998
- 1998-06-03 HK HK98104832A patent/HK1005731A1/xx not_active IP Right Cessation
- 1998-06-03 HK HK98104822A patent/HK1005725A1/xx not_active IP Right Cessation
- 1998-09-28 HK HK98111030A patent/HK1010456A1/xx not_active IP Right Cessation
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