DK0528164T3 - Anvendelse af xanthinderivater til fremstilling af et lægemiddel til behandling af sekundære nervecelleskader og funktionsforstyrrelser efter kranie-hjerne-traumer - Google Patents

Anvendelse af xanthinderivater til fremstilling af et lægemiddel til behandling af sekundære nervecelleskader og funktionsforstyrrelser efter kranie-hjerne-traumer

Info

Publication number
DK0528164T3
DK0528164T3 DK92111761.0T DK92111761T DK0528164T3 DK 0528164 T3 DK0528164 T3 DK 0528164T3 DK 92111761 T DK92111761 T DK 92111761T DK 0528164 T3 DK0528164 T3 DK 0528164T3
Authority
DK
Denmark
Prior art keywords
manufacture
treatment
drug
xanthine derivatives
nerve cell
Prior art date
Application number
DK92111761.0T
Other languages
Danish (da)
English (en)
Inventor
Hans-Peter Prof Dr Schubert
Karl Dr Rudolphi
Ulrich Dr Gebert
John J Dr Grome
Barbara Dr Kittner
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0528164T3 publication Critical patent/DK0528164T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92111761.0T 1991-07-11 1992-07-10 Anvendelse af xanthinderivater til fremstilling af et lægemiddel til behandling af sekundære nervecelleskader og funktionsforstyrrelser efter kranie-hjerne-traumer DK0528164T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4122884 1991-07-11
DE4217639 1992-05-28

Publications (1)

Publication Number Publication Date
DK0528164T3 true DK0528164T3 (da) 1996-09-30

Family

ID=25905369

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92111761.0T DK0528164T3 (da) 1991-07-11 1992-07-10 Anvendelse af xanthinderivater til fremstilling af et lægemiddel til behandling af sekundære nervecelleskader og funktionsforstyrrelser efter kranie-hjerne-traumer

Country Status (20)

Country Link
US (1) US5409935A (cg-RX-API-DMAC7.html)
EP (1) EP0528164B1 (cg-RX-API-DMAC7.html)
JP (1) JP3436547B2 (cg-RX-API-DMAC7.html)
KR (1) KR100237945B1 (cg-RX-API-DMAC7.html)
AT (1) ATE138573T1 (cg-RX-API-DMAC7.html)
AU (1) AU649851B2 (cg-RX-API-DMAC7.html)
CA (1) CA2073633C (cg-RX-API-DMAC7.html)
CZ (2) CZ281480B6 (cg-RX-API-DMAC7.html)
DE (1) DE59206403D1 (cg-RX-API-DMAC7.html)
DK (1) DK0528164T3 (cg-RX-API-DMAC7.html)
ES (1) ES2088519T3 (cg-RX-API-DMAC7.html)
GR (1) GR3020233T3 (cg-RX-API-DMAC7.html)
HU (1) HU217983B (cg-RX-API-DMAC7.html)
IE (1) IE74888B1 (cg-RX-API-DMAC7.html)
IL (1) IL102456A (cg-RX-API-DMAC7.html)
MX (1) MX9203323A (cg-RX-API-DMAC7.html)
PH (1) PH30341A (cg-RX-API-DMAC7.html)
RU (1) RU2126407C1 (cg-RX-API-DMAC7.html)
SK (1) SK280537B6 (cg-RX-API-DMAC7.html)
TW (1) TW210285B (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648357A (en) * 1992-03-04 1997-07-15 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds
US5567704A (en) * 1992-03-04 1996-10-22 Cell Therapeutics, Inc. R-enatiomerically pure hydroxylated xanthine compounds to treat baldness
CA2112239C (en) * 1992-03-04 2000-05-09 James A. Bianco Enantiomeric hydroxylated xanthine compounds
EP0570831A2 (de) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation
WO1995013075A1 (en) * 1993-11-12 1995-05-18 Cell Therapeutics, Inc. Method for preventing tissue injury from hypoxia
US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
IL150150A0 (en) * 2000-01-14 2002-12-01 Schering Ag 1,2-diaryl benzimidazoles for treating illnesses associated with a microglia activation
US7115645B2 (en) 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
US7329679B2 (en) 2000-01-27 2008-02-12 Schering Aktiengesellschaft 1,2 Diarylbenzimidazoles and their pharmaceutical use
US20040110776A1 (en) * 2002-02-22 2004-06-10 Iok-Hou Pang Use of propentofylline to control intraocular pressure
EP1515972B1 (en) * 2002-06-12 2009-05-13 F. Hoffmann-La Roche Ag Amide substituted xanthine derivatives with gluconeogenesis modulating activity
WO2005037286A1 (en) * 2003-03-25 2005-04-28 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2330742C2 (de) * 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CH608236A5 (cg-RX-API-DMAC7.html) * 1974-01-22 1978-12-29 Wuelfing J A Fa
US4275064A (en) * 1976-02-06 1981-06-23 Interx Research Corporation Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents
FR2531085A1 (fr) * 1982-07-28 1984-02-03 Adir Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant
IT1200944B (it) * 1982-08-10 1989-01-27 Malesci Sas Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico
US4567183A (en) * 1983-03-11 1986-01-28 Analgesic Associates Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
JPS6110715A (ja) * 1984-06-26 1986-01-18 Fanuc Ltd 絶対位置検出方式
JPH062675B2 (ja) * 1985-04-05 1994-01-12 ヘキストジヤパン株式会社 記憶障害治療剤
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IT1197516B (it) * 1986-12-24 1988-11-30 Abc Ist Biolog Chem Spa Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
IT1229195B (it) * 1989-03-10 1991-07-25 Poli Ind Chimica Spa Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives

Also Published As

Publication number Publication date
DE59206403D1 (de) 1996-07-04
HUT61763A (en) 1993-03-01
KR100237945B1 (ko) 2000-02-01
TW210285B (cg-RX-API-DMAC7.html) 1993-08-01
CZ281480B6 (cs) 1996-10-16
SK216092A3 (en) 1995-09-13
PH30341A (en) 1997-04-02
IL102456A (en) 1996-10-16
IE922259A1 (en) 1993-01-13
HU217983B (hu) 2000-05-28
MX9203323A (es) 1994-07-29
ES2088519T3 (es) 1996-08-16
EP0528164A3 (cg-RX-API-DMAC7.html) 1994-03-02
IL102456A0 (en) 1993-01-14
RU94027686A (ru) 1996-05-27
EP0528164A2 (de) 1993-02-24
AU649851B2 (en) 1994-06-02
KR930001911A (ko) 1993-02-22
HU9202273D0 (en) 1992-10-28
ATE138573T1 (de) 1996-06-15
IE74888B1 (en) 1997-08-13
CZ282140B6 (cs) 1997-05-14
EP0528164B1 (de) 1996-05-29
JP3436547B2 (ja) 2003-08-11
SK280537B6 (sk) 2000-03-13
CA2073633A1 (en) 1993-01-12
US5409935A (en) 1995-04-25
CZ81696A3 (en) 1997-05-14
JPH05186350A (ja) 1993-07-27
AU1959192A (en) 1993-01-14
CZ216092A3 (en) 1993-01-13
GR3020233T3 (en) 1996-09-30
RU2126407C1 (ru) 1999-02-20
CA2073633C (en) 2003-09-23

Similar Documents

Publication Publication Date Title
GR3020233T3 (en) Use of xanthine derivatives for the manufacture of a medicament for the treatment of secondary nerve cell damages and function disorders after head-brain-traumata
SE8801729D0 (sv) Purine derivatives for use in therapy
DK499088A (da) 1-oe(2-pyrimidinyl)-aminoalkylaapiperidinderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende saadanne derivater
DK425487A (da) Pharmaceutisk aktive derivater af glutamin- og asparginsyre
ZA834532B (en) Novel derivatives of guanine i
ATE49000T1 (de) Pyrido(1,2-a>pyrimidinderivate.
SE8304545D0 (sv) Benzamide derivatives
DE69200365D1 (de) Pharmazeutische Zusammensetzung zur Verbesserung von Dysuria.
DE3160621D1 (en) Triazoloquinazolinone derivatives and their acid addition salts, their preparation, their use as medicaments and compositions containing them
GR3007087T3 (cg-RX-API-DMAC7.html)
IL89185A (en) 5-halo-2-(omega-)(4-(2-pyrimidinyl)-1-piperazinyl(alkyl)thieno-(2.3-d)isothiazol-3(2h)-one 1,1-dioxides,their preparation and pharmaceutical compositions containing them
DE3366181D1 (en) 2-aminomethyl-6-sulfamoylphenol derivatives, process for their preparation, their use and pharmaceutical preparations based on these compounds
GR861646B (en) 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidino-5-carbonic acid -(n-triphthoro - methyl-phenyl)-amides for antithrombotic protection and treatment use and preparation of antithrombotically active medicines
DE3862660D1 (de) 2,3-dihydro-2-oxo-3-benzofuranyl-essigsaeurederivate und diese enthaltende arzneimittel.
IL60176A0 (en) Xanthine derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
ATE57185T1 (de) Pyrido(1,2-a>pyrimidinderivate.
ES8103047A1 (es) Procedimiento de preparacion de derivados aminoisoquinolinosasi como de sus sales de adicion acidas, farmaceuticamente aceptables y de sus derivados amonicos cuaternarios
GR3006582T3 (cg-RX-API-DMAC7.html)
JPS5430161A (en) 2-aminomethylbenzoxazoles and their pharmaceutically acceptable acid salts