DK0512883T3 - Fremgangsmåde til fremstilling af et koncentrat af blodkoaguleringsfaktor XI med høj specifik aktivitet, til terapeutisk anvendelse - Google Patents
Fremgangsmåde til fremstilling af et koncentrat af blodkoaguleringsfaktor XI med høj specifik aktivitet, til terapeutisk anvendelseInfo
- Publication number
- DK0512883T3 DK0512883T3 DK92401157.0T DK92401157T DK0512883T3 DK 0512883 T3 DK0512883 T3 DK 0512883T3 DK 92401157 T DK92401157 T DK 92401157T DK 0512883 T3 DK0512883 T3 DK 0512883T3
- Authority
- DK
- Denmark
- Prior art keywords
- concentrate
- specific activity
- high specific
- therapeutic use
- preparing
- Prior art date
Links
- 239000012141 concentrate Substances 0.000 title abstract 3
- 108010074864 Factor XI Proteins 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 201000007219 factor XI deficiency Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000009256 replacement therapy Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6443—Coagulation factor XIa (3.4.21.27)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21027—Coagulation factor XIa (3.4.21.27)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9105572A FR2676231A1 (fr) | 1991-05-07 | 1991-05-07 | Concentre de facteur xi de la coagulation sanguine a haute activite specifique, approprie a usage therapeutique et son procede de preparation. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0512883T3 true DK0512883T3 (da) | 1998-03-16 |
Family
ID=9412593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92401157.0T DK0512883T3 (da) | 1991-05-07 | 1992-04-23 | Fremgangsmåde til fremstilling af et koncentrat af blodkoaguleringsfaktor XI med høj specifik aktivitet, til terapeutisk anvendelse |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5252217A (https=) |
| EP (1) | EP0512883B1 (https=) |
| AT (1) | ATE156360T1 (https=) |
| AU (1) | AU652043B2 (https=) |
| BR (1) | BR9201718A (https=) |
| CA (1) | CA2068069C (https=) |
| DE (1) | DE69221369T2 (https=) |
| DK (1) | DK0512883T3 (https=) |
| EE (1) | EE03017B1 (https=) |
| ES (1) | ES2107511T3 (https=) |
| FR (1) | FR2676231A1 (https=) |
| GR (1) | GR3025134T3 (https=) |
| IL (1) | IL99567A (https=) |
| LT (1) | LT3417B (https=) |
| RU (1) | RU2097047C1 (https=) |
| UA (1) | UA27733C2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2151604C1 (ru) * | 1999-01-21 | 2000-06-27 | Станкевич Виктор Евгеньевич | Способ приготовления универсальной гемотрансфузионной среды |
| AU2002354846B2 (en) * | 2001-07-20 | 2007-08-02 | Novo Nordisk Health Care Ag | Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides |
| US20030040480A1 (en) * | 2001-07-20 | 2003-02-27 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides |
| US20050181978A1 (en) * | 2003-11-20 | 2005-08-18 | Rasmus Rojkjaer | Therapeutic use of factor XI |
| RU2006115783A (ru) * | 2003-11-20 | 2007-12-27 | Ново Нордиск Хелс Кеа Аг (Ch) | Терапевтическое применение фактора xi |
| WO2006128497A1 (en) * | 2005-06-01 | 2006-12-07 | Novo Nordisk A/S | Pharmaceutical formulation of factor xi |
| CN101511387A (zh) * | 2006-09-08 | 2009-08-19 | 惠氏公司 | 使用亲和色谱法纯化蛋白质的精氨酸洗涤液 |
| EP2102335B1 (en) * | 2007-01-04 | 2012-02-22 | Crucell Holland B.V. | Purification of factor xi |
| KR101773551B1 (ko) * | 2008-10-15 | 2017-08-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | 인자 １１ 발현의 조정 |
| FR2974301B1 (fr) * | 2011-04-20 | 2013-08-23 | Lab Francais Du Fractionnement | Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes |
| FR2974366B1 (fr) * | 2011-04-20 | 2016-06-24 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre de facteur xi |
| IL212911A0 (en) | 2011-05-16 | 2011-07-31 | Omrix Biopharmaceuticals Ltd | Immunoglobulin reduced in thrombogenic contaminants and preparation thereof |
| DE102012022233A1 (de) | 2012-11-14 | 2014-05-15 | Instraction Gmbh | Verfahren zur Reinigung eines (Blut)plasmaproteins |
| DE102012022234A1 (de) | 2012-11-14 | 2014-05-15 | Instraction Gmbh | Einstufiges Verfahren zur Reinigung von (Blut)Plasmaproteinen wie Albumin aus Gemischen |
| FR3032621A1 (fr) | 2015-02-13 | 2016-08-19 | Lab Francais Du Fractionnement | Colle biologique et son utilisation comme medicament |
| KR101941974B1 (ko) * | 2016-11-18 | 2019-01-24 | 주식회사 녹십자 | 혈장 단백질 정제시 fxi의 제거방법 |
| CU20200082A7 (es) | 2018-05-09 | 2021-06-08 | Ionis Pharmaceuticals Inc | Compuestos y métodos para la reducción de la expresión de fxi |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859340A (en) * | 1976-03-15 | 1989-08-22 | Cuno, Incorporated | Filter sheet |
| US4783262A (en) * | 1987-03-30 | 1988-11-08 | Cuno Incorporated | Separator for cell type filter element |
-
1991
- 1991-05-07 FR FR9105572A patent/FR2676231A1/fr active Granted
- 1991-09-25 IL IL9956791A patent/IL99567A/en not_active IP Right Cessation
-
1992
- 1992-04-23 DK DK92401157.0T patent/DK0512883T3/da active
- 1992-04-23 AT AT92401157T patent/ATE156360T1/de active
- 1992-04-23 DE DE69221369T patent/DE69221369T2/de not_active Expired - Lifetime
- 1992-04-23 EP EP92401157A patent/EP0512883B1/fr not_active Expired - Lifetime
- 1992-04-23 ES ES92401157T patent/ES2107511T3/es not_active Expired - Lifetime
- 1992-04-29 AU AU15263/92A patent/AU652043B2/en not_active Expired
- 1992-05-06 RU SU925011788A patent/RU2097047C1/ru active
- 1992-05-06 CA CA002068069A patent/CA2068069C/en not_active Expired - Lifetime
- 1992-05-07 BR BR929201718A patent/BR9201718A/pt not_active Application Discontinuation
- 1992-05-07 US US07/879,273 patent/US5252217A/en not_active Expired - Lifetime
- 1992-12-29 LT LTIP265A patent/LT3417B/lt not_active IP Right Cessation
-
1993
- 1993-05-21 UA UA93002714A patent/UA27733C2/uk unknown
-
1994
- 1994-05-23 EE EE9400003A patent/EE03017B1/xx not_active IP Right Cessation
-
1997
- 1997-10-22 GR GR970402766T patent/GR3025134T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69221369D1 (de) | 1997-09-11 |
| DE69221369T2 (de) | 1998-03-19 |
| CA2068069A1 (en) | 1992-11-08 |
| EP0512883A1 (fr) | 1992-11-11 |
| CA2068069C (en) | 2005-03-15 |
| UA27733C2 (uk) | 2000-10-16 |
| IL99567A (en) | 1996-01-19 |
| ES2107511T3 (es) | 1997-12-01 |
| US5252217A (en) | 1993-10-12 |
| AU1526392A (en) | 1992-11-12 |
| LT3417B (en) | 1995-09-25 |
| EP0512883B1 (fr) | 1997-08-06 |
| AU652043B2 (en) | 1994-08-11 |
| GR3025134T3 (en) | 1998-02-27 |
| ATE156360T1 (de) | 1997-08-15 |
| LTIP265A (en) | 1994-10-25 |
| IL99567A0 (en) | 1992-08-18 |
| FR2676231B1 (https=) | 1995-04-21 |
| FR2676231A1 (fr) | 1992-11-13 |
| EE03017B1 (et) | 1997-08-15 |
| BR9201718A (pt) | 1992-12-29 |
| RU2097047C1 (ru) | 1997-11-27 |
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