DK0508699T3 - 9-deoxo-8a-aza-8a-homoerythromycin-A-derivater modificeret ved 4"- og 8a-stillingerne - Google Patents

9-deoxo-8a-aza-8a-homoerythromycin-A-derivater modificeret ved 4"- og 8a-stillingerne

Info

Publication number
DK0508699T3
DK0508699T3 DK92303003.5T DK92303003T DK0508699T3 DK 0508699 T3 DK0508699 T3 DK 0508699T3 DK 92303003 T DK92303003 T DK 92303003T DK 0508699 T3 DK0508699 T3 DK 0508699T3
Authority
DK
Denmark
Prior art keywords
hydrogen
homoerythromycin
deoxo
aza
positions
Prior art date
Application number
DK92303003.5T
Other languages
Danish (da)
English (en)
Inventor
Thomas N Salzmann
James V Heck
William J Leanza
Robert R Wilkening
Ronald W Ratcliffe
Michael J Szymonifka
Kothandaraman Shankaran
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/855,242 external-priority patent/US5985844A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0508699T3 publication Critical patent/DK0508699T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DK92303003.5T 1991-04-04 1992-04-03 9-deoxo-8a-aza-8a-homoerythromycin-A-derivater modificeret ved 4"- og 8a-stillingerne DK0508699T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68021791A 1991-04-04 1991-04-04
US81116191A 1991-12-19 1991-12-19
US07/855,242 US5985844A (en) 1992-03-26 1992-03-26 Homoerythromycin A derivatives modified at the 4"-and 8A-positions

Publications (1)

Publication Number Publication Date
DK0508699T3 true DK0508699T3 (da) 1998-05-04

Family

ID=27418367

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92303003.5T DK0508699T3 (da) 1991-04-04 1992-04-03 9-deoxo-8a-aza-8a-homoerythromycin-A-derivater modificeret ved 4"- og 8a-stillingerne

Country Status (12)

Country Link
EP (1) EP0508699B1 (de)
JP (1) JP2503156B2 (de)
AT (1) ATE164165T1 (de)
CA (1) CA2064634C (de)
CY (1) CY2097B1 (de)
DE (1) DE69224765T2 (de)
DK (1) DK0508699T3 (de)
ES (1) ES2113410T3 (de)
GR (1) GR3026677T3 (de)
HK (1) HK1009649A1 (de)
IE (1) IE921076A1 (de)
LV (1) LV12211B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (de) * 1991-12-20 1993-06-30 Merck & Co. Inc. Verfahren zur Herstellung von 4"-Derivaten von 9-Deoxo-8a-Aza-8a-Alkyl-8a-Homoerythromycin A
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5958888A (en) * 1996-07-02 1999-09-28 Merial, Inc. Water miscible macrolide solutions
AU4911097A (en) * 1996-11-15 1998-06-03 Pharmacia & Upjohn Company 1- and 2-substituted marcfortines and paraherquamides as antiparasitic agents
GB9705323D0 (en) * 1997-03-14 1997-04-30 Biochemie Sa Organic compounds
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
US6407074B1 (en) 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
GB9806029D0 (en) * 1998-03-20 1998-05-20 Merck & Co Inc 8a-Azalides as veterinary antimicrobial agents
JP2003512290A (ja) * 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての８ａ−アザライド
KR100426510B1 (ko) * 1997-09-10 2004-04-13 머크 앤드 캄파니 인코포레이티드 수의용 항미생물제로서의 8ａ-아잘리드
AU1082599A (en) * 1997-10-16 1999-05-03 Merck & Co., Inc. 8a-azalides, compositions containing such compounds and methods of treatment
US6733767B2 (en) * 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
EP1437360A3 (de) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11-Carbamate von antibakteriellen Makroliden
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6353096B1 (en) 1999-04-01 2002-03-05 Merial Process of use in converting the 4″(S)-OH functional group of the cladinose unit of an azamacrolide to 4″(R)-NH2
FR2788524B1 (fr) * 1999-01-18 2002-04-26 Merial Sas Procede utile pour transformer la fonction 4"(s)-oh du motif cladinose d'un aza macrolide en 4"(r)-nh2
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide
OA11945A (en) 1999-05-24 2006-04-13 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
US6590084B2 (en) 1999-12-20 2003-07-08 Merial Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
FR2802534B1 (fr) * 1999-12-20 2002-02-01 Merial Sas Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
FR2806724B1 (fr) * 2000-03-24 2003-12-05 Merial Sas Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
US6562953B2 (en) 2000-05-30 2003-05-13 Merial Process which is useful for converting the carbonyl function in position 4″ of the cladinose unit of an aza-macrolide into an amine derivative
FR2809728B1 (fr) * 2000-05-30 2003-02-28 Merial Sas Procede utile pour transformer la fonction carbonyle en position 4" du motif cladinose d'un aza macrolide en un derive amine
GB0025688D0 (en) 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
CN100413879C (zh) 2001-04-27 2008-08-27 辉瑞产品公司 4″-取代-9-脱氧-9a-氮杂-9a-高红霉素A衍生物的制备方法
GB0127349D0 (en) * 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
JP2008540503A (ja) 2005-05-10 2008-11-20 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 細菌感染症の処置に有用なエーテル結合マクロライド
US20080312167A1 (en) * 2005-05-10 2008-12-18 Sulejman Alihodzic 4'' Amino Linked Macrolides Useful for the Treatment of Microbial Infections
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
NZ592373A (en) 2008-10-24 2012-01-12 Merial Ltd Method of synthesizing antibacterial macrolide compounds
CN112521617B (zh) * 2020-05-21 2022-05-10 南阳师范学院 一种可用于吸附抗生素的多酸基金属有机框架材料及其制备方法和用途
CN113332238A (zh) * 2021-06-09 2021-09-03 四川恒通动保生物科技有限公司 一种加米霉素的复合溶液剂的制备方法
WO2023038852A1 (en) * 2021-09-07 2023-03-16 Zoetis Services Llc Immunomodulating azalides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
SI8911498B (sl) * 1989-07-26 1998-10-31 Pliva Postopek za pripravo derivatov tilozina
YU45590A (sh) * 1990-03-07 1992-07-20 PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje

Also Published As

Publication number Publication date
CA2064634A1 (en) 1992-10-05
DE69224765T2 (de) 1998-10-15
LV12211B (en) 1999-03-20
CA2064634C (en) 1998-08-04
GR3026677T3 (en) 1998-07-31
IE921076A1 (en) 1992-10-07
EP0508699A1 (de) 1992-10-14
LV12211A (lv) 1999-01-20
CY2097B1 (en) 2002-04-05
HK1009649A1 (en) 1999-06-04
JP2503156B2 (ja) 1996-06-05
EP0508699B1 (de) 1998-03-18
JPH05255375A (ja) 1993-10-05
DE69224765D1 (de) 1998-04-23
ES2113410T3 (es) 1998-05-01
ATE164165T1 (de) 1998-04-15

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