DK0496830T3 - Total syntese af northebain, normorphin, noroxymorphonenantiomerer og derivater via N-nor-mellemprodukter - Google Patents
Total syntese af northebain, normorphin, noroxymorphonenantiomerer og derivater via N-nor-mellemprodukterInfo
- Publication number
- DK0496830T3 DK0496830T3 DK90917159T DK90917159T DK0496830T3 DK 0496830 T3 DK0496830 T3 DK 0496830T3 DK 90917159 T DK90917159 T DK 90917159T DK 90917159 T DK90917159 T DK 90917159T DK 0496830 T3 DK0496830 T3 DK 0496830T3
- Authority
- DK
- Denmark
- Prior art keywords
- ether
- intermediates
- northebain
- noroxymorphone
- normorphine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42190089A | 1989-10-16 | 1989-10-16 | |
PCT/US1990/005911 WO1991005768A1 (en) | 1989-10-16 | 1990-10-16 | Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0496830T3 true DK0496830T3 (da) | 1999-10-11 |
Family
ID=23672545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90917159T DK0496830T3 (da) | 1989-10-16 | 1990-10-16 | Total syntese af northebain, normorphin, noroxymorphonenantiomerer og derivater via N-nor-mellemprodukter |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0496830B1 (ja) |
JP (1) | JP2694156B2 (ja) |
AT (1) | ATE178329T1 (ja) |
AU (1) | AU642447B2 (ja) |
CA (1) | CA2067200C (ja) |
DE (1) | DE69033035T2 (ja) |
DK (1) | DK0496830T3 (ja) |
ES (1) | ES2129395T3 (ja) |
GR (1) | GR3030101T3 (ja) |
WO (1) | WO1991005768A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006084389A1 (de) * | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
EP1893616B1 (en) * | 2005-06-16 | 2010-12-29 | Mallinckrodt, Inc. | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
WO2008131567A1 (de) * | 2007-04-27 | 2008-11-06 | Cilag Ag | Lösungsmittelfreie kristalline form von naltrexon |
WO2009067275A1 (en) * | 2007-11-21 | 2009-05-28 | Progenics Pharmaceuticals, Inc | N-oxides of 4,5-epoxy-morphinanium analogs |
EP2222642B1 (en) * | 2007-12-17 | 2014-02-12 | Mallinckrodt LLC | Process and compounds for the production of (+) opiates |
JP5579076B2 (ja) * | 2007-12-17 | 2014-08-27 | マリンクロッド エルエルシー | シノメニン誘導体およびそれらの合成のためのプロセス |
US8580963B2 (en) | 2010-11-05 | 2013-11-12 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
JO3209B1 (ar) * | 2010-11-05 | 2018-03-08 | H Lundbeck As | طريقة لتصنيع نالتريكسون |
AU2011325563B2 (en) | 2010-11-05 | 2015-08-20 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
WO2012151669A1 (en) * | 2011-05-06 | 2012-11-15 | Brock University | Process for the preparation of morphine analogs via metal catalyzed n-demethylation/functionalization and intramolecular group transfer |
WO2013164383A1 (en) | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
ES2631197T3 (es) * | 2012-12-14 | 2017-08-29 | Purdue Pharma Lp | Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes |
US9340542B2 (en) | 2013-12-26 | 2016-05-17 | Purdue Pharma L.P. | Propellane-based compounds and the use thereof |
MA40170A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés hétérocycliques de morphinan et leur utilisation |
CA3194746A1 (en) | 2020-10-06 | 2022-04-14 | Tien-Li Lee | Oral delayed burst formulation of low-dose naltrexone or naloxone used for|treating fibromyalgia and long covid |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA913077A (en) * | 1972-10-24 | J. Pachter Irwin | Process of preparing n-substituted 14-hydroxydihydronormorphines | |
BE638369A (ja) * | 1962-10-10 | |||
FR2208902A1 (en) * | 1972-06-15 | 1974-06-28 | Merck & Co Inc | 14-Hydroxy dihydronormorphinone prepn. - from 1-halo-nor codeinone, by oxidn., catalytic redn. and hydrolysis |
US4141897A (en) * | 1976-12-20 | 1979-02-27 | Research Corporation | N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof |
NO793297L (no) * | 1978-10-19 | 1980-04-22 | Mallinckrodt Inc | Fremgangsmaate til fremstilling av oksymorfon |
NO802139L (no) * | 1979-08-09 | 1981-02-10 | Mallinckrodt Inc | Utgangsforbindelser for fremstilling av morfinderivater, samt fremgangsmaate til fremstilling av utgangsforbindelsene |
US4368326A (en) * | 1980-07-03 | 1983-01-11 | Rice Kenner C | Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone |
US4521601A (en) * | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
US4472253A (en) * | 1981-08-17 | 1984-09-18 | The Florida Board Of Regents On Behalf Of The Florida State University | Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative |
US4613668A (en) * | 1983-12-22 | 1986-09-23 | The United States Of America As Represented By The Department Of Health And Human Services | Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
US4639520A (en) * | 1984-03-27 | 1987-01-27 | Mallinckrodt, Inc. | Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone |
JPS62123444A (ja) * | 1985-08-07 | 1987-06-04 | Japan Synthetic Rubber Co Ltd | ポジ型感放射線性樹脂組成物 |
JPH0721626B2 (ja) * | 1985-08-10 | 1995-03-08 | 日本合成ゴム株式会社 | 半導体微細加工用レジスト組成物 |
-
1990
- 1990-10-16 ES ES90917159T patent/ES2129395T3/es not_active Expired - Lifetime
- 1990-10-16 DE DE69033035T patent/DE69033035T2/de not_active Expired - Fee Related
- 1990-10-16 WO PCT/US1990/005911 patent/WO1991005768A1/en active IP Right Grant
- 1990-10-16 CA CA002067200A patent/CA2067200C/en not_active Expired - Lifetime
- 1990-10-16 AT AT90917159T patent/ATE178329T1/de not_active IP Right Cessation
- 1990-10-16 JP JP3500396A patent/JP2694156B2/ja not_active Expired - Fee Related
- 1990-10-16 AU AU67426/90A patent/AU642447B2/en not_active Ceased
- 1990-10-16 DK DK90917159T patent/DK0496830T3/da active
- 1990-10-16 EP EP90917159A patent/EP0496830B1/en not_active Expired - Lifetime
-
1999
- 1999-04-30 GR GR990401183T patent/GR3030101T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0496830A4 (en) | 1992-09-30 |
JP2694156B2 (ja) | 1997-12-24 |
ES2129395T3 (es) | 1999-06-16 |
AU6742690A (en) | 1991-05-16 |
EP0496830A1 (en) | 1992-08-05 |
EP0496830B1 (en) | 1999-03-31 |
CA2067200A1 (en) | 1991-04-17 |
ATE178329T1 (de) | 1999-04-15 |
AU642447B2 (en) | 1993-10-21 |
DE69033035D1 (de) | 1999-05-06 |
CA2067200C (en) | 1998-06-30 |
DE69033035T2 (de) | 1999-08-05 |
GR3030101T3 (en) | 1999-07-30 |
JPH04504861A (ja) | 1992-08-27 |
WO1991005768A1 (en) | 1991-05-02 |
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