DK0486290T3 - Fremgangsmåde og præparat til forøgelse af akkumulering af squalen og specifikke steroler i gær - Google Patents

Fremgangsmåde og præparat til forøgelse af akkumulering af squalen og specifikke steroler i gær

Info

Publication number
DK0486290T3
DK0486290T3 DK91310494T DK91310494T DK0486290T3 DK 0486290 T3 DK0486290 T3 DK 0486290T3 DK 91310494 T DK91310494 T DK 91310494T DK 91310494 T DK91310494 T DK 91310494T DK 0486290 T3 DK0486290 T3 DK 0486290T3
Authority
DK
Denmark
Prior art keywords
squalene
yeast
accumulation
enhancing
preparation
Prior art date
Application number
DK91310494T
Other languages
Danish (da)
English (en)
Inventor
Court A Saunders
Fred Richard Wolf
Indrani Mukharji
Original Assignee
Bp Corp North America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bp Corp North America Inc filed Critical Bp Corp North America Inc
Application granted granted Critical
Publication of DK0486290T3 publication Critical patent/DK0486290T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces
    • C12R2001/865—Saccharomyces cerevisiae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK91310494T 1990-11-15 1991-11-14 Fremgangsmåde og præparat til forøgelse af akkumulering af squalen og specifikke steroler i gær DK0486290T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61338090A 1990-11-15 1990-11-15
US07/783,861 US5460949A (en) 1990-11-15 1991-10-28 Method and composition for increasing the accumulation of squalene and specific sterols in yeast

Publications (1)

Publication Number Publication Date
DK0486290T3 true DK0486290T3 (da) 2002-09-16

Family

ID=27087007

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91310494T DK0486290T3 (da) 1990-11-15 1991-11-14 Fremgangsmåde og præparat til forøgelse af akkumulering af squalen og specifikke steroler i gær

Country Status (6)

Country Link
US (1) US5460949A (es)
EP (1) EP0486290B1 (es)
JP (1) JP3283551B2 (es)
DE (1) DE69133012T2 (es)
DK (1) DK0486290T3 (es)
ES (1) ES2176177T3 (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741898A (en) * 1994-09-22 1998-04-21 Hanley; Kathleen Marie DNA sequence encoding nicotiana squalene synthetase
US20020086380A1 (en) * 1996-03-29 2002-07-04 Francis X. Cunningham Jr Genes encoding epsilon lycopene cyclase and method for producing bicyclic carotene
DE19744212B4 (de) * 1997-09-30 2006-01-19 Schering Ag Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen
EP0955363A3 (en) * 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
CA2331343C (en) 1998-07-06 2014-01-14 Dcv, Inc., Doing Business As Bio-Technical Resources Production of isoprenoid in recombinant yeast
US6410755B1 (en) 1998-07-06 2002-06-25 Dcv, Inc. Method of vitamin production
WO2000001686A1 (en) 1998-07-06 2000-01-13 Eastman Chemical Company Method of producing vitamin e
US6399796B2 (en) 2000-03-17 2002-06-04 Roche Vitamins Inc. Activation of a Diels-Alder reaction of a sterol 5,7-diene
US7009045B2 (en) * 2000-07-14 2006-03-07 Archer-Daniels-Midland Company Transformation systems for flavinogenic yeast
JP3838033B2 (ja) * 2000-12-28 2006-10-25 トヨタ自動車株式会社 プレニルアルコールの製造方法
WO2002053747A1 (en) * 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Process for producing prenyl alcohol
JP3894119B2 (ja) * 2000-12-28 2007-03-14 トヨタ自動車株式会社 プレニルアルコールの製造方法
US6822142B2 (en) * 2001-01-05 2004-11-23 Monsanto Company Transgenic plants containing altered levels of steroid compounds
DE10203352A1 (de) * 2002-01-29 2003-07-31 Basf Ag Verfahren zur Herstellung von 7-Dehydrocholesterol und/oder dessen biosynthetischen Zwischen- und/oder Folgeprodukten in transgenen Organismen
DE10312314A1 (de) 2003-03-19 2004-09-30 Basf Ag Verfahren zur Herstellung von Ergosta-5,7-dienol und/oder dessen biosynthetischen Zwischen- und/oder Folgeprodukten in transgenen Organismen
FR2869914B1 (fr) * 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications
ATE537269T1 (de) 2004-05-21 2011-12-15 Univ California Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen
EP1775304A4 (en) * 2004-07-13 2010-04-28 Mitsubishi Chem Corp PROCESS FOR THE PRODUCTION OF STEROIDS
US8828684B2 (en) * 2004-07-27 2014-09-09 The Regents Of The University Of California Genetically modified host cells and use of same for producing isoprenoid compounds
AU2006227165B2 (en) 2005-03-18 2011-11-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
BRPI0614990A2 (pt) * 2005-08-19 2011-04-26 Univ California células hospedeiras geneticamente modificadas e uso das mesmas para produção de compostos isoprenóides
WO2007044688A1 (en) * 2005-10-07 2007-04-19 The Regents Of The University Of California Nucleic acids encoding modified cytochrome p450 enzymes and methods of use thereof
JP2007210888A (ja) 2006-01-12 2007-08-23 Mitsubishi Chemicals Corp ステロイド化合物の製造方法
US8114645B2 (en) * 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
AU2007267033B2 (en) * 2006-05-26 2012-05-24 Amyris, Inc. Production of isoprenoids
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
WO2008130372A2 (en) 2006-09-28 2008-10-30 Microbia, Inc. Production of sterols in oleaginous yeast and fungi
WO2009006429A1 (en) * 2007-06-29 2009-01-08 Regents Of The University Of California Host cells and methods for producing 3-methyl-2-buten-1-ol, 3-methyl-3-buten-1-ol, and 3-methyl-butan-1-ol
WO2009006386A2 (en) 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing isoprenyl alkanoates
CA2725175A1 (en) 2008-05-23 2009-11-26 Cibus Oils, Llc Production of squalene using yeast
RS51999B (en) 2008-08-28 2012-04-30 Novartis Ag Obtaining squalene from hyperproductive yeasts
DE102009022772A1 (de) * 2009-05-21 2010-11-25 Organobalance Gmbh Mikroorganismus zur Expression eines humanen Membranproteins
JP4821886B2 (ja) * 2009-06-04 2011-11-24 トヨタ自動車株式会社 組換え酵母、当該組換え酵母を用いた分岐アルコールの製造方法
JP2012531917A (ja) * 2009-07-01 2012-12-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 微細藻類コロニーからの細胞外テルペノイドの抽出法
EP2292741A1 (en) 2009-08-26 2011-03-09 OrganoBalance GmbH Genetically modified organisms for the production of lipids
UA111813C2 (uk) 2009-11-23 2016-06-24 Нукеліс, Інк. Спосіб одержання сквалену з застосуванням дріжджів
WO2011067144A1 (en) 2009-12-03 2011-06-09 Dsm Ip Assets B.V. Production of non-yeast sterols by yeast
BR122021005283B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol
WO2012116783A2 (en) 2011-02-28 2012-09-07 Organobalance Gmbh A yeast cell for the production of terpenes and uses thereof
EP3009508B1 (en) 2011-08-08 2020-11-25 Evolva SA Recombinant production of steviol glycosides
IN2014CN01129A (es) 2011-08-08 2015-04-10 Evolva Sa
CA2899276C (en) 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US10017804B2 (en) 2013-02-11 2018-07-10 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
WO2014139989A1 (en) * 2013-03-13 2014-09-18 Sanofi-Aventis Deutschland Gmbh Production of squalene and/or sterol from cell suspensions of fermented yeast
WO2015156369A1 (ja) * 2014-04-09 2015-10-15 株式会社Adeka 変異酵素及び前記変異酵素を用いたテルペノイドの製造方法
JP2017528125A (ja) 2014-08-11 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの産生
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの生産
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3271457B1 (en) 2015-03-16 2021-01-20 DSM IP Assets B.V. Udp-glycosyltransferases
EP3332018B1 (en) 2015-08-07 2022-07-27 Evolva SA Production of steviol glycosides in recombinant hosts
CN109195457A (zh) 2016-04-13 2019-01-11 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts

Also Published As

Publication number Publication date
EP0486290A2 (en) 1992-05-20
DE69133012T2 (de) 2003-01-02
EP0486290B1 (en) 2002-05-22
JPH05192184A (ja) 1993-08-03
EP0486290A3 (en) 1993-03-17
JP3283551B2 (ja) 2002-05-20
US5460949A (en) 1995-10-24
DE69133012D1 (de) 2002-06-27
ES2176177T3 (es) 2002-12-01

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