DK0474691T3 - Monoklonale antistoffer til induktion af tolerance - Google Patents

Monoklonale antistoffer til induktion af tolerance

Info

Publication number
DK0474691T3
DK0474691T3 DK90908270.3T DK90908270T DK0474691T3 DK 0474691 T3 DK0474691 T3 DK 0474691T3 DK 90908270 T DK90908270 T DK 90908270T DK 0474691 T3 DK0474691 T3 DK 0474691T3
Authority
DK
Denmark
Prior art keywords
depleting
monoclonal antibodies
induce tolerance
monoclonal antibody
tolerance
Prior art date
Application number
DK90908270.3T
Other languages
Danish (da)
English (en)
Inventor
Stephen Paul Cobbold
Herman Waldmann
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of DK0474691T3 publication Critical patent/DK0474691T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK90908270.3T 1989-05-31 1990-05-31 Monoklonale antistoffer til induktion af tolerance DK0474691T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912497A GB8912497D0 (en) 1989-05-31 1989-05-31 Monoclonal antibodies

Publications (1)

Publication Number Publication Date
DK0474691T3 true DK0474691T3 (da) 1996-12-02

Family

ID=10657649

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90908270.3T DK0474691T3 (da) 1989-05-31 1990-05-31 Monoklonale antistoffer til induktion af tolerance

Country Status (19)

Country Link
EP (1) EP0474691B1 (ja)
JP (1) JP2763197B2 (ja)
KR (1) KR0183029B1 (ja)
AT (1) ATE145246T1 (ja)
AU (1) AU657255B2 (ja)
CA (1) CA2055615C (ja)
DD (1) DD296843A5 (ja)
DE (1) DE69029134T2 (ja)
DK (1) DK0474691T3 (ja)
ES (1) ES2096588T3 (ja)
GB (1) GB8912497D0 (ja)
HU (1) HUT61341A (ja)
IE (1) IE80735B1 (ja)
IL (1) IL94566A0 (ja)
MY (1) MY135673A (ja)
NZ (1) NZ233889A (ja)
PT (1) PT94214B (ja)
WO (1) WO1990015152A1 (ja)
ZA (1) ZA904174B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100741D0 (en) * 1991-01-14 1991-02-27 Univ London Treatment of disease
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
WO1994004188A1 (en) * 1992-08-21 1994-03-03 Genentech, Inc. Method for treating an lfa-1-mediated disorder
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
DE69627665T2 (de) * 1995-05-18 2004-02-19 Ortho-Mcneil Pharmaceutical, Inc. Induktion von immunologischer toleranz unter verwendung von nicht-zellmengeverringernden anti-cd4-antikoepern
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
ES2316446T3 (es) 2000-04-29 2009-04-16 University Of Iowa Research Foundation Diagnostico y terapeutica para trastornos relacionados con la degeneracion macular.
CA2450700A1 (en) * 2001-06-14 2002-12-27 Mark Frewin Trx1 antibody and uses therefor
US7541443B2 (en) 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
EP1460088A1 (en) 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
GB0314461D0 (en) * 2003-06-20 2003-07-23 Isis Innovation Suppression of transplant rejection
KR20070036138A (ko) * 2004-06-22 2007-04-02 톨러알엑스, 인크. 영장류에서 관용 유발을 위한 항-ｃｄ４ 항체를 사용하는최적화 용량 결정
WO2009121690A1 (en) 2008-03-13 2009-10-08 Biotest Ag Agent for treating disease
RU2540018C2 (ru) 2008-03-13 2015-01-27 Биотест Аг Средство для лечения заболевания
CN102027016A (zh) 2008-03-13 2011-04-20 生物测试股份公司 一种治疗疾病的试剂
EP2297204A4 (en) * 2008-06-06 2013-10-23 Baylor Res Inst ANTI-CD8 ANTIBODIES BLOCK THE PRIMES OF CYTOTOXIC EFFECTORS AND LEAD TO THE FORMATION OF REGULATORY CD8 + T CELLS
US20100021460A1 (en) * 2008-07-15 2010-01-28 Genentech, Inc. Methods of Treating Autoimmune Diseases Using CD4 Antibodies
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
JPH04505919A (ja) 1992-10-15
JP2763197B2 (ja) 1998-06-11
DE69029134D1 (de) 1996-12-19
PT94214B (pt) 1997-03-31
AU5725890A (en) 1991-01-07
IE901949L (en) 1990-11-30
DD296843A5 (de) 1991-12-19
MY135673A (en) 2008-06-30
NZ233889A (en) 1997-06-24
EP0474691A1 (en) 1992-03-18
ATE145246T1 (de) 1996-11-15
CA2055615A1 (en) 1990-12-13
IE80735B1 (en) 1998-12-30
EP0474691B1 (en) 1996-11-13
IL94566A0 (en) 1991-03-10
KR0183029B1 (ko) 1999-04-01
AU657255B2 (en) 1995-03-09
HU905134D0 (en) 1992-02-28
HUT61341A (en) 1992-12-28
CA2055615C (en) 2001-07-17
GB8912497D0 (en) 1989-07-19
ES2096588T3 (es) 1997-03-16
ZA904174B (en) 1992-02-26
DE69029134T2 (de) 1997-03-06
WO1990015152A1 (en) 1990-12-13
PT94214A (pt) 1991-02-08

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