DK0464325T3 - Fremgangsmåde til fremstilling af salte af L-ornithin - Google Patents
Fremgangsmåde til fremstilling af salte af L-ornithinInfo
- Publication number
- DK0464325T3 DK0464325T3 DK91105851.9T DK91105851T DK0464325T3 DK 0464325 T3 DK0464325 T3 DK 0464325T3 DK 91105851 T DK91105851 T DK 91105851T DK 0464325 T3 DK0464325 T3 DK 0464325T3
- Authority
- DK
- Denmark
- Prior art keywords
- ornithine
- salts
- preparation
- prepared
- reaction mixture
- Prior art date
Links
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 title abstract 6
- 150000003839 salts Chemical class 0.000 title abstract 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003104 ornithine Drugs 0.000 title abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4020980A DE4020980C1 (enExample) | 1990-07-02 | 1990-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0464325T3 true DK0464325T3 (da) | 1995-11-27 |
Family
ID=6409473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91105851.9T DK0464325T3 (da) | 1990-07-02 | 1991-04-12 | Fremgangsmåde til fremstilling af salte af L-ornithin |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5405761A (enExample) |
| EP (1) | EP0464325B1 (enExample) |
| JP (1) | JPH04229184A (enExample) |
| AT (1) | ATE126829T1 (enExample) |
| DE (2) | DE4020980C1 (enExample) |
| DK (1) | DK0464325T3 (enExample) |
| ES (1) | ES2076398T3 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591613A (en) * | 1990-07-02 | 1997-01-07 | Degussa Aktiengesellschaft | Method for the preparation of D-arginine and L-ornithine |
| DE9116462U1 (de) * | 1991-06-10 | 1992-11-19 | Degussa-Hüls AG, 60311 Frankfurt | Stabilisierte, metallionenaktivierte L-Arginase (L-Arginin Amidinohydrolase; E.C. 3.5.3.1.) |
| JP4042397B2 (ja) * | 2001-11-07 | 2008-02-06 | ひかり製菓株式会社 | 呈味改良剤 |
| WO2006001345A1 (ja) * | 2004-06-23 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | Ｌ－リジン・クエン酸塩結晶 |
| CN1972899A (zh) * | 2004-06-25 | 2007-05-30 | 协和发酵工业株式会社 | L－鸟氨酸·柠檬酸盐结晶 |
| DE602005019319D1 (de) | 2004-11-26 | 2010-03-25 | Ucl Business Plc | Zusammensetzungen mit ornithin und phenylacetat oder phenylbutyrat zur behandlung von hepatischer enzephalopathie |
| CN1322139C (zh) * | 2004-12-15 | 2007-06-20 | 南京大学 | 固定化细胞酶法制备l－鸟氨酸的方法 |
| CN101851646B (zh) * | 2009-03-31 | 2013-11-27 | 上海汉飞生化科技有限公司 | 一种固定化酶法生产l-鸟氨酸盐酸盐的方法 |
| PT2413924T (pt) | 2009-04-03 | 2018-01-04 | Ocera Therapeutics Inc | Fenil acetato de l-ornitina e métodos de preparação do mesmo |
| EA025735B1 (ru) | 2009-06-08 | 2017-01-30 | ЮСиЭл БИЗНЕС ПиЭлСи | Способ лечения портальной гипертензии с использованием l-орнитина в сочетании по меньшей мере с одним из соединений, выбранных из фенилацетата и фенилбутирата |
| EA028395B1 (ru) | 2010-10-06 | 2017-11-30 | Осера Терапьютикс, Инк. | Способы получения фенилацетата l-орнитина |
| CN102863346B (zh) * | 2012-09-07 | 2014-12-31 | 宜兴市前成生物有限公司 | 一种制备l-天门冬氨酸-l-鸟氨酸的方法 |
| BR112017010761B1 (pt) | 2014-11-24 | 2022-10-18 | Ucl Business Plc | Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia |
| WO2016144247A1 (en) | 2015-03-12 | 2016-09-15 | Biopetrolia Ab | L-ornithine production in eukaryotic cells |
| CN105175275B (zh) * | 2015-07-01 | 2017-03-01 | 山东民强生物科技股份有限公司 | 一种l‑鸟氨酸的分离纯化方法 |
| JP6990170B2 (ja) | 2015-08-18 | 2022-01-12 | オセラ セラピューティクス， インコーポレイテッド | Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防 |
| CN106699586B (zh) * | 2016-12-08 | 2019-01-25 | 陕西天宇制药有限公司 | 门冬氨酸鸟氨酸的制备方法 |
| AU2018266357B2 (en) | 2017-05-11 | 2022-12-08 | Ocera Therapeutics, Inc. | Processes of making L-ornithine phenylacetate |
| CN108440324B (zh) * | 2018-04-19 | 2021-04-20 | 成都倍特药业股份有限公司 | 一种门冬氨酸鸟氨酸及其结晶方法 |
| CN109651181A (zh) * | 2018-12-29 | 2019-04-19 | 南通紫琅生物医药科技有限公司 | 一种l-鸟氨酸盐酸盐生产工艺 |
| CN113372232B (zh) * | 2021-06-04 | 2023-06-13 | 无锡晶海氨基酸股份有限公司 | 去除盐酸鸟氨酸中鸟氨酸内酰胺的方法 |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2988489A (en) * | 1957-09-19 | 1961-06-13 | Kyowa Hakko Kogyo Kk | Method of producing l-ornithine by fermentation |
| CH421984A (fr) * | 1962-07-14 | 1966-10-15 | Ajinomoto Kk | Procédé de préparation d'acides aminés |
| US3668072A (en) * | 1969-01-02 | 1972-06-06 | Chugai Pharmaceutical Co Ltd | Fermentation process for the production of l-ornithine |
| US4248677A (en) * | 1978-07-10 | 1981-02-03 | Tokuyama Soda Kabushiki Kaisha | Process for producing alpha-aminocarboxylic acids and salts thereof |
| DE2945790C2 (de) * | 1978-11-20 | 1987-03-12 | Tanabe Seiyaku Co., Ltd., Osaka | Neutrales L-Ornithin-L-malat-dihydrat und neutrales L-Lysin-L-malat-monohydrat und Verfahren zu deren Herstellung |
| US4346169A (en) * | 1980-09-15 | 1982-08-24 | Ajinomoto Company, Incorporated | Method for production of L-arginine by fermentation |
| US4698442A (en) * | 1982-12-21 | 1987-10-06 | Syntex (U.S.A.) Inc. | ω-Guanidino-substituted-α-amino acids |
| US4882226A (en) * | 1986-09-23 | 1989-11-21 | Akzo N.V. | Carrier material for use in chromatography or carrying out enzymatic reactions |
| US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
-
1990
- 1990-07-02 DE DE4020980A patent/DE4020980C1/de not_active Expired - Lifetime
-
1991
- 1991-04-12 DE DE59106289T patent/DE59106289D1/de not_active Expired - Fee Related
- 1991-04-12 DK DK91105851.9T patent/DK0464325T3/da active
- 1991-04-12 AT AT91105851T patent/ATE126829T1/de not_active IP Right Cessation
- 1991-04-12 EP EP91105851A patent/EP0464325B1/de not_active Expired - Lifetime
- 1991-04-12 ES ES91105851T patent/ES2076398T3/es not_active Expired - Lifetime
- 1991-06-17 US US07/715,963 patent/US5405761A/en not_active Expired - Fee Related
- 1991-07-01 JP JP3160190A patent/JPH04229184A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US5405761A (en) | 1995-04-11 |
| EP0464325A2 (de) | 1992-01-08 |
| DE4020980C1 (enExample) | 1991-09-26 |
| EP0464325A3 (en) | 1992-04-08 |
| JPH04229184A (ja) | 1992-08-18 |
| ES2076398T3 (es) | 1995-11-01 |
| DE59106289D1 (de) | 1995-09-28 |
| EP0464325B1 (de) | 1995-08-23 |
| ATE126829T1 (de) | 1995-09-15 |
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