DK0451654T3 - Anvendelse af N-alkylerede 1,4-dihydropyridin-dicarboxylsyreestere som lægemidler, nye forbindelser og fremgangsmåder til deres fremstilling - Google Patents

Anvendelse af N-alkylerede 1,4-dihydropyridin-dicarboxylsyreestere som lægemidler, nye forbindelser og fremgangsmåder til deres fremstilling

Info

Publication number
DK0451654T3
DK0451654T3 DK91105115.9T DK91105115T DK0451654T3 DK 0451654 T3 DK0451654 T3 DK 0451654T3 DK 91105115 T DK91105115 T DK 91105115T DK 0451654 T3 DK0451654 T3 DK 0451654T3
Authority
DK
Denmark
Prior art keywords
alkylated
drugs
preparation
acid esters
methods
Prior art date
Application number
DK91105115.9T
Other languages
Danish (da)
English (en)
Inventor
Siegfried Dr Goldmann
Otto Dr Behner
Hartmut Dr Wollweber
Bruno Dr Rosen
Siegfried Dr Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0451654T3 publication Critical patent/DK0451654T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK91105115.9T 1990-04-11 1991-03-30 Anvendelse af N-alkylerede 1,4-dihydropyridin-dicarboxylsyreestere som lægemidler, nye forbindelser og fremgangsmåder til deres fremstilling DK0451654T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011695A DE4011695A1 (de) 1990-04-11 1990-04-11 Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DK0451654T3 true DK0451654T3 (da) 1995-02-13

Family

ID=6404197

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91105115.9T DK0451654T3 (da) 1990-04-11 1991-03-30 Anvendelse af N-alkylerede 1,4-dihydropyridin-dicarboxylsyreestere som lægemidler, nye forbindelser og fremgangsmåder til deres fremstilling

Country Status (18)

Country Link
US (2) US5234935A (pl)
EP (1) EP0451654B1 (pl)
JP (1) JP3012352B2 (pl)
KR (1) KR0180741B1 (pl)
AT (1) ATE111079T1 (pl)
AU (1) AU642992B2 (pl)
CA (1) CA2040062A1 (pl)
DE (2) DE4011695A1 (pl)
DK (1) DK0451654T3 (pl)
ES (1) ES2063998T3 (pl)
FI (1) FI101377B (pl)
HU (2) HUT59905A (pl)
IE (1) IE64452B1 (pl)
IL (1) IL97796A (pl)
NZ (1) NZ237722A (pl)
PT (1) PT97300B (pl)
TW (1) TW197423B (pl)
ZA (1) ZA912652B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
WO1993006082A1 (en) * 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
DE4133257A1 (de) * 1991-10-08 1993-04-15 Bayer Ag N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum
DE4200714A1 (de) * 1992-01-14 1993-07-15 Bayer Ag Spezieller 1,4-dihydropyridin-3,5-dicarbonsaeureester, verfahren zu seiner herstellung und seine pharmazeutische verwendung
DE4223867A1 (de) * 1992-07-20 1994-01-27 Bayer Ag Spezieller 1,4-Dihydropyridin-3,5-dicarbonsäureester, Verfahren zu seiner Herstellung und seine pharmazeutische Verwendung
DE4313691A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 2,6-Disubstituierte 4-Chinolyl-dihydropyridine
DE4313692A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE4313697A1 (de) * 1993-04-27 1994-11-03 Bayer Ag Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE4328884A1 (de) * 1993-08-27 1995-03-02 Bayer Ag Verwendung von N-alkylierten 1,4-Dihydropyridincarbonsäureestern als Arzneimittel
EE03192B1 (et) * 1993-12-10 1999-06-15 Bayer Aktiengesellschaft Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine
ES2193148T3 (es) * 1993-12-10 2003-11-01 Bayer Ag 1,4-dihidropiridinas sustituidas con fenilo con actividad cerebral.
DE4430094A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verwendung von 3,5-Dicarbonsäureester-1,4-Dihydropyridinen als Arzneimittel
DE19638570A1 (de) * 1996-09-20 1998-03-26 Bayer Ag Wirkstoffhaltige thermoplastische Polyurethane
WO2003053930A1 (en) * 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
CN110606822A (zh) 2011-11-24 2019-12-24 里克特吉迪翁公司 具有hsp调节活性的1,4-二氢吡啶衍生物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1813436C3 (de) * 1968-12-07 1979-01-11 Bayer Ag, 5090 Leverkusen N-Substituierte 2,6-Dimethyl-l,4dihydropyridine
US3883543A (en) * 1969-05-10 1975-05-13 Bayer Ag N-alkyl-1,4-dihydropyridines
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
CH550189A (de) * 1971-01-08 1974-06-14 Ciba Geigy Ag Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren.
DE2210667A1 (de) * 1972-03-06 1973-09-20 Bayer Ag Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2228377A1 (de) * 1972-06-10 1974-01-03 Bayer Ag Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH569043A5 (pl) * 1973-01-23 1975-11-14 Ciba Geigy Ag
US3956341A (en) * 1974-02-21 1976-05-11 Smithkline Corporation 1,3,5-Tricarbo-1,4-dihydropyridines
SU798099A1 (ru) * 1978-03-06 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp 1-Бензил-2,6-диметил-4-о-или-M-НиТРОфЕНил-3,5-диэТОКСиКАРбОНил- 1,4-дигидРОпиРидиНы, пРО Вл ющиЕКОРОНАРОдилАТиРующую АКТиВНОСТь
US4975440A (en) * 1984-09-28 1990-12-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Optically-active 1,4-dihydropyridine
EP0176956B1 (de) * 1984-09-28 1994-06-15 Byk Gulden Lomberg Chemische Fabrik GmbH Neue Diarylverbindungen
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
GB8616047D0 (en) * 1986-07-01 1986-08-06 Sandoz Ltd A 1 4-dihydropyridine derivatives
GR1002248B (en) * 1988-03-08 1996-04-23 Egyt Gyogyszervegyeszeti Gyar 1,4-dihydropyridine derivatives preparation method

Also Published As

Publication number Publication date
FI911700A (fi) 1991-10-12
DE4011695A1 (de) 1991-10-17
IE64452B1 (en) 1995-08-09
JP3012352B2 (ja) 2000-02-21
IL97796A (en) 1995-03-15
FI101377B1 (fi) 1998-06-15
HU911184D0 (en) 1991-10-28
NZ237722A (en) 1995-10-26
EP0451654A2 (de) 1991-10-16
EP0451654A3 (en) 1992-07-08
PT97300A (pt) 1992-01-31
HUT59905A (en) 1992-07-28
ATE111079T1 (de) 1994-09-15
US5234935A (en) 1993-08-10
IE911200A1 (en) 1991-10-23
EP0451654B1 (de) 1994-09-07
FI911700A0 (fi) 1991-04-09
HU211313A9 (en) 1995-11-28
KR910018025A (ko) 1991-11-30
FI101377B (fi) 1998-06-15
DE59102788D1 (de) 1994-10-13
KR0180741B1 (ko) 1999-03-20
ZA912652B (en) 1992-01-29
AU642992B2 (en) 1993-11-04
JPH04234847A (ja) 1992-08-24
US5432185A (en) 1995-07-11
IL97796A0 (en) 1992-06-21
PT97300B (pt) 1998-10-30
TW197423B (pl) 1993-01-01
CA2040062A1 (en) 1991-10-12
ES2063998T3 (es) 1995-01-16
AU7425391A (en) 1991-10-17

Similar Documents

Publication Publication Date Title
DK0451654T3 (da) Anvendelse af N-alkylerede 1,4-dihydropyridin-dicarboxylsyreestere som lægemidler, nye forbindelser og fremgangsmåder til deres fremstilling
MX9301348A (es) Nuevos compuestos que tienen actividad farmacologica, proceso para su preparacion y composicion farmaceutica que los comprende.
DE69223965D1 (de) Anticonvulsives aminosäurederivat
FI20115753A (fi) Farmaseuttisia koostumuksia IL-6:n tuoton aiheuttamien sairauksien hoitoon
BR9713186A (pt) Inibidores de metaloprotease 1,3-diheterocìclicos
BR9810841A (pt) Inibidores de metaloprotease alicìclicos
RU93005168A (ru) Индолиновые производные, способ их получения, промежуточные соединения синтеза, использование промежуточных соединений и фармацевтическая композиция
HUP9900508A2 (hu) 2-Amino-4-(4-fluor-benzil-amino)-1-(etoxi-karbonil-amino)-benzol alkalmazása agyi vérellátási zavarok, valamint neurodegeneratív megbetegedések következményeinek megelőzésére és kezelésére alkalmas gyógyszerkészítmények előállítására
SE8302361D0 (sv) New tricyclic amines
RU93055870A (ru) Производные бифенила, способ их получения и фармацевтическая композиция для лечения гипертонии и сердечных заболеваний
RU93045145A (ru) Замещенные производные циклогексана и их применение для лечения заболеваний, содержащее их лекарственное средство
RU94031161A (ru) Фармацевтическая композиция и способ ее получения, способ лечения нарушений, развивающихся вследствие нейродегенеративных процессов
FI103116B1 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten, N-substituoitujen atsaheterosyklisten karboksyylihappojohdannaisten valmistamiseksi
DE59010302D1 (de) R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthin, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel
DK0814791T3 (da) Aminotetralin-derivat til behandlingen af cardiovaskulære sygdomme
DE3380923D1 (de) Pharmazeutische zusammensetzungen zur behandlung von stoerungen, bedingt durch humanendrogen.
ES2060440T3 (es) Derivados de acidos 1,4-dihidropiridin-dicarboxilicos aril-quinolil substituidos, procedimiento para su fabricacion y su uso en medicamentos.
DK65691D0 (da) 2-aminocarboxylsyre-derivater, deres fremstilling og anvendelse som laegemidler
DE69025967D1 (de) Aryl- oder Heteroaryl-1-alkyl-pyrrol-2-carbonsäure-Derivate, zur Behandlung von durch Interleukin-1 hervorgerufenen Erkrankungen
NO933521D0 (no) Acylsulfonamido- og sulfonamidopyridin-2-karboksylsyreester samt deres pyridin-n-oksyder, fremgangsmaater for deres fremstilling og deres anvendelse som legemiddel
MX9306509A (es) Dihidroporidinas sustituidas por 4-heterociclilo, procedimiento para su obtencion y medicamentos quelas contienen.
RU95101840A (ru) Сложные эфиры циклогексанола и содержащий их фармацевтический препарат
RU93052408A (ru) Ациламино-алкилиден-гидрокси-бис-фосфоновые кислоты, способ их получения, фармацевтическая композиция
MX9303706A (es) 9-amino-piridazino[4', 5': 3, 4]pirrolo-[2, 1-a]isoquinolinas y su empleo para la produccion de preparados farmaceuticos.
DK0950053T3 (da) Hidtil ukendte benzoylalkyl.1,2,3,6-tetrahydropyridinderivater