FI911700A - Anvaendning av n-alkylerade 1,4 -dihydropyridinkarboxylsyraestrar som laekemedel, nya foereningar och foerfarande foer deras framstaellning. - Google Patents

Anvaendning av n-alkylerade 1,4 -dihydropyridinkarboxylsyraestrar som laekemedel, nya foereningar och foerfarande foer deras framstaellning. Download PDF

Info

Publication number
FI911700A
FI911700A FI911700A FI911700A FI911700A FI 911700 A FI911700 A FI 911700A FI 911700 A FI911700 A FI 911700A FI 911700 A FI911700 A FI 911700A FI 911700 A FI911700 A FI 911700A
Authority
FI
Finland
Prior art keywords
dihydropyridinkarboxylsyraestrar
alkylerade
anvaendning
foerfarande foer
och foerfarande
Prior art date
Application number
FI911700A
Other languages
English (en)
Other versions
FI101377B (fi
FI101377B1 (fi
FI911700A0 (fi
Inventor
Otto Behner
Hartmut Wollweber
Bruno Rosen
Siegfried Zaiss
Siegfried Goldmann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI911700A0 publication Critical patent/FI911700A0/fi
Publication of FI911700A publication Critical patent/FI911700A/fi
Application granted granted Critical
Publication of FI101377B publication Critical patent/FI101377B/fi
Publication of FI101377B1 publication Critical patent/FI101377B1/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI911700A 1990-04-11 1991-04-09 Menetelmä N-alkyloitujen 1,4-dihydropyridiiniyhdisteiden valmistamiseksi FI101377B1 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4011695 1990-04-11
DE4011695A DE4011695A1 (de) 1990-04-11 1990-04-11 Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung

Publications (4)

Publication Number Publication Date
FI911700A0 FI911700A0 (fi) 1991-04-09
FI911700A true FI911700A (fi) 1991-10-12
FI101377B FI101377B (fi) 1998-06-15
FI101377B1 FI101377B1 (fi) 1998-06-15

Family

ID=6404197

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911700A FI101377B1 (fi) 1990-04-11 1991-04-09 Menetelmä N-alkyloitujen 1,4-dihydropyridiiniyhdisteiden valmistamiseksi

Country Status (18)

Country Link
US (2) US5234935A (fi)
EP (1) EP0451654B1 (fi)
JP (1) JP3012352B2 (fi)
KR (1) KR0180741B1 (fi)
AT (1) ATE111079T1 (fi)
AU (1) AU642992B2 (fi)
CA (1) CA2040062A1 (fi)
DE (2) DE4011695A1 (fi)
DK (1) DK0451654T3 (fi)
ES (1) ES2063998T3 (fi)
FI (1) FI101377B1 (fi)
HU (2) HUT59905A (fi)
IE (1) IE64452B1 (fi)
IL (1) IL97796A (fi)
NZ (1) NZ237722A (fi)
PT (1) PT97300B (fi)
TW (1) TW197423B (fi)
ZA (1) ZA912652B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
WO1993006082A1 (en) * 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
DE4133257A1 (de) * 1991-10-08 1993-04-15 Bayer Ag N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum
DE4200714A1 (de) * 1992-01-14 1993-07-15 Bayer Ag Spezieller 1,4-dihydropyridin-3,5-dicarbonsaeureester, verfahren zu seiner herstellung und seine pharmazeutische verwendung
DE4223867A1 (de) * 1992-07-20 1994-01-27 Bayer Ag Spezieller 1,4-Dihydropyridin-3,5-dicarbonsäureester, Verfahren zu seiner Herstellung und seine pharmazeutische Verwendung
DE4313691A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 2,6-Disubstituierte 4-Chinolyl-dihydropyridine
DE4313697A1 (de) * 1993-04-27 1994-11-03 Bayer Ag Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE4313692A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE4328884A1 (de) * 1993-08-27 1995-03-02 Bayer Ag Verwendung von N-alkylierten 1,4-Dihydropyridincarbonsäureestern als Arzneimittel
PT657432E (pt) * 1993-12-10 2003-07-31 Bayer Ag 1,4-di-hidropiridinas fenil-substituidas com actividade cerebral
EE03192B1 (et) * 1993-12-10 1999-06-15 Bayer Aktiengesellschaft Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine
DE4430094A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verwendung von 3,5-Dicarbonsäureester-1,4-Dihydropyridinen als Arzneimittel
DE19638570A1 (de) * 1996-09-20 1998-03-26 Bayer Ag Wirkstoffhaltige thermoplastische Polyurethane
JP4486817B2 (ja) 2001-12-20 2010-06-23 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト １，４−ジヒドロ−１，４−ジフェニルピリジン誘導体
US8420790B2 (en) * 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
EP2782573B1 (en) 2011-11-24 2019-10-09 Richter Gedeon Nyrt. 1,4-dihydropyridine derivatives with hsp modulating activity

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1813436C3 (de) * 1968-12-07 1979-01-11 Bayer Ag, 5090 Leverkusen N-Substituierte 2,6-Dimethyl-l,4dihydropyridine
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
US3883543A (en) * 1969-05-10 1975-05-13 Bayer Ag N-alkyl-1,4-dihydropyridines
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
CH550189A (de) * 1971-01-08 1974-06-14 Ciba Geigy Ag Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren.
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2210667A1 (de) * 1972-03-06 1973-09-20 Bayer Ag Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2228377A1 (de) * 1972-06-10 1974-01-03 Bayer Ag Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH569043A5 (fi) * 1973-01-23 1975-11-14 Ciba Geigy Ag
US3956341A (en) * 1974-02-21 1976-05-11 Smithkline Corporation 1,3,5-Tricarbo-1,4-dihydropyridines
SU798099A1 (ru) * 1978-03-06 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp 1-Бензил-2,6-диметил-4-о-или-M-НиТРОфЕНил-3,5-диэТОКСиКАРбОНил- 1,4-дигидРОпиРидиНы, пРО Вл ющиЕКОРОНАРОдилАТиРующую АКТиВНОСТь
US4975440A (en) * 1984-09-28 1990-12-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Optically-active 1,4-dihydropyridine
EP0176956B1 (de) * 1984-09-28 1994-06-15 Byk Gulden Lomberg Chemische Fabrik GmbH Neue Diarylverbindungen
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
GB8616047D0 (en) * 1986-07-01 1986-08-06 Sandoz Ltd A 1 4-dihydropyridine derivatives
GR1002248B (en) * 1988-03-08 1996-04-23 Egyt Gyogyszervegyeszeti Gyar 1,4-dihydropyridine derivatives preparation method

Also Published As

Publication number Publication date
HU211313A9 (en) 1995-11-28
PT97300B (pt) 1998-10-30
ATE111079T1 (de) 1994-09-15
FI101377B (fi) 1998-06-15
IE64452B1 (en) 1995-08-09
KR0180741B1 (ko) 1999-03-20
KR910018025A (ko) 1991-11-30
DK0451654T3 (da) 1995-02-13
CA2040062A1 (en) 1991-10-12
ES2063998T3 (es) 1995-01-16
US5432185A (en) 1995-07-11
AU642992B2 (en) 1993-11-04
IL97796A0 (en) 1992-06-21
HU911184D0 (en) 1991-10-28
AU7425391A (en) 1991-10-17
ZA912652B (en) 1992-01-29
DE4011695A1 (de) 1991-10-17
JP3012352B2 (ja) 2000-02-21
DE59102788D1 (de) 1994-10-13
TW197423B (fi) 1993-01-01
HUT59905A (en) 1992-07-28
US5234935A (en) 1993-08-10
FI101377B1 (fi) 1998-06-15
EP0451654B1 (de) 1994-09-07
FI911700A0 (fi) 1991-04-09
IE911200A1 (en) 1991-10-23
NZ237722A (en) 1995-10-26
JPH04234847A (ja) 1992-08-24
PT97300A (pt) 1992-01-31
IL97796A (en) 1995-03-15
EP0451654A2 (de) 1991-10-16
EP0451654A3 (en) 1992-07-08

Similar Documents

Publication Publication Date Title
FI911700A0 (fi) Anvaendning av n-alkylerade 1,4 -dihydropyridinkarboxylsyraestrar som laekemedel, nya foereningar och foerfarande foer deras framstaellning.
RU94041223A (ru) Средство для лечения мотонейроновых заболеваний
DE3779500D1 (de) Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
ATE82121T1 (de) Arzneimittel fuer die therapeutische behandlung von alopezie.
MX9300014A (es) Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su elaboracion.
MX9301348A (es) Nuevos compuestos que tienen actividad farmacologica, proceso para su preparacion y composicion farmaceutica que los comprende.
RU92016463A (ru) Применение производных цистина для изготовления лекарственных препаратов с иммуномоделирующим действием, фармацевтические композиции на их основе
IT8322855A0 (it) Composizione farmaceutica per la cura delle arteriopatie periferiche.
RU93045145A (ru) Замещенные производные циклогексана и их применение для лечения заболеваний, содержащее их лекарственное средство
DK0412554T3 (da) Sustained-release-præparat til administration i hjernen
YU49215B (sh) Primena flupirtina za dobijanje medikamenta za tretman neurodegenerativnih oboljenja
ATE123944T1 (de) Verwendung von trifluormethylphenyl- tetrahydropyridinen zur herstellung von arzneimitteln zur behandlung anxio-depressiver erkrankungen.
FR2618331B1 (fr) Compositions pharmaceutiques utiles pour le traitement de l'uremie
ES2153842T3 (es) Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central.
DE59010302D1 (de) R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthin, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel
WO1993017691A3 (en) Pharmaceutical compositions containing monosialoganglioside gm1 or a derivative thereof suitable for the treatment of parkinson's disease
DE3380923D1 (de) Pharmazeutische zusammensetzungen zur behandlung von stoerungen, bedingt durch humanendrogen.
ES2060440T3 (es) Derivados de acidos 1,4-dihidropiridin-dicarboxilicos aril-quinolil substituidos, procedimiento para su fabricacion y su uso en medicamentos.
KR880002535A (ko) 약제로서의 15-데옥시스퍼구알린의 용도
NO913644D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
DE68901172D1 (de) (-)-2-pyrazolinverbindung, deren optischen aufspaltung und therapeutisches agens zur behandlung von zerebralen gefaesskrankheiten, diese verbindung als aktives ingredient enthaltend.
RU95101840A (ru) Сложные эфиры циклогексанола и содержащий их фармацевтический препарат
RU97104062A (ru) Применение селегилина для лечения эпилептических заболеваний
KR960003718A (ko) 말초신경병 및 중추신경변성병의 치료에 유용한 의약의 제조를 위한 이펜프로딜 및 그 부분입체이성질체의 이용
DE69009765D1 (de) Kynurensäurederivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.