DK0415296T4 - Nye højalkaliske proteaser - Google Patents

Nye højalkaliske proteaser

Info

Publication number
DK0415296T4
DK0415296T4 DK90116322T DK90116322T DK0415296T4 DK 0415296 T4 DK0415296 T4 DK 0415296T4 DK 90116322 T DK90116322 T DK 90116322T DK 90116322 T DK90116322 T DK 90116322T DK 0415296 T4 DK0415296 T4 DK 0415296T4
Authority
DK
Denmark
Prior art keywords
dna sequences
amino acids
alkaline proteases
alkaline
point mutation
Prior art date
Application number
DK90116322T
Other languages
English (en)
Other versions
DK0415296T3 (da
Inventor
Roman Vetter
Detlef Wilke
Andre Clippe
Wolfgang Aehle
Dietmar Schomburg
Antoine Amory
Original Assignee
Biotechnolog Forschung Gmbh
Genencor Internat Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25884604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0415296(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotechnolog Forschung Gmbh, Genencor Internat Gmbh filed Critical Biotechnolog Forschung Gmbh
Publication of DK0415296T3 publication Critical patent/DK0415296T3/da
Application granted granted Critical
Publication of DK0415296T4 publication Critical patent/DK0415296T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK90116322T 1989-08-31 1990-08-25 Nye højalkaliske proteaser DK0415296T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3928804 1989-08-31
DE4023458A DE4023458A1 (de) 1989-08-31 1990-07-24 Neue hochalkalische proteasen

Publications (2)

Publication Number Publication Date
DK0415296T3 DK0415296T3 (da) 1996-11-18
DK0415296T4 true DK0415296T4 (da) 2001-11-12

Family

ID=25884604

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90116322T DK0415296T4 (da) 1989-08-31 1990-08-25 Nye højalkaliske proteaser

Country Status (7)

Country Link
EP (1) EP0415296B2 (da)
JP (1) JPH03139277A (da)
KR (1) KR100196785B1 (da)
AT (1) ATE143689T1 (da)
DE (2) DE4023458A1 (da)
DK (1) DK0415296T4 (da)
ES (1) ES2093624T5 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482849A (en) * 1990-12-21 1996-01-09 Novo Nordisk A/S Subtilisin mutants
ATE159757T1 (de) * 1990-12-21 1997-11-15 Novo Nordisk As Enzym-mutanten mit einer geringen variation der molekularladung über einen ph-bereich
DE4106525A1 (de) * 1991-03-01 1992-09-10 Solvay Enzymes Gmbh & Co Kg Verfahren zur verbesserung der stabilitaet von hochalkalischen proteasen
DK58391D0 (da) * 1991-04-03 1991-04-03 Novo Nordisk As Hidtil ukendte proteaser
EP0995801A1 (de) * 1991-07-27 2000-04-26 Genencor International GmbH Verfahren zur Verbesserung des Stabilität von Enzymen und stabilisierte Enzyme
ES2198514T3 (es) * 1991-08-27 2004-02-01 F. Hoffmann-La Roche Ag Cebadores y sondas para la deteccion de la hepatitis c.
US5371198A (en) * 1991-12-16 1994-12-06 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
US5256557A (en) * 1991-12-27 1993-10-26 Solvay Enzymes, Inc. Purified alkaline protease concentrate and method of preparation
US5623059A (en) * 1992-03-09 1997-04-22 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
DE69333463D1 (de) * 1992-05-18 2004-05-06 Genencor Int Alkalische Proteasen produzierende Bakterien, und Verfahren zur Herstellung dieser alkalischen Proteasen
JP4028592B2 (ja) * 1992-07-17 2007-12-26 ジェネンコー インターナショナル インコーポレイテッド 高アルカリ性セリンプロテアーゼ
DE4304161A1 (de) * 1993-02-12 1994-08-25 Solvay Enzymes Gmbh & Co Kg Verbesserte hochalkalische Proteasen
DE4411223A1 (de) * 1994-03-31 1995-10-05 Solvay Enzymes Gmbh & Co Kg Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren
CN103181400B (zh) 2004-09-10 2016-08-10 诺维信北美公司 防止、去除、减少或破坏生物膜的方法
BR112012028466B1 (pt) * 2010-05-06 2020-03-17 The Procter & Gamble Company Composição de produtos com variantes de protease e método para tratar e/ou limpar uma superfície
WO2012001145A1 (en) 2010-07-01 2012-01-05 Novozymes A/S Bleaching of pulp
CA2834865C (en) 2011-05-05 2021-03-09 Danisco Us Inc. Compositions and methods comprising serine protease variants
BR112014005290B1 (pt) 2011-09-09 2021-11-09 Novozymes A/S Método para melhoramento da resistência do papel
AU2013326968B2 (en) * 2012-10-03 2019-08-08 Agrivida, Inc. Multiprotein expression cassettes
EP2740840A1 (en) 2012-12-07 2014-06-11 Novozymes A/S Improving drainage of paper pulp
WO2016007309A1 (en) 2014-07-07 2016-01-14 Novozymes A/S Use of prehydrolysate liquor in engineered wood
CN114402105B (zh) 2019-07-26 2024-01-30 诺维信公司 纸浆的酶处理
CA3182928A1 (en) 2020-05-29 2021-12-02 Novozymes A/S Method for controlling slime in a pulp or paper making process
CA3220135A1 (en) 2021-06-16 2022-12-22 Novozymes A/S Method for controlling slime in a pulp or paper making process
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770587A (en) * 1971-02-09 1973-11-06 Pfizer Chemically modified proteolytic enzymes
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
FR2598430B1 (fr) * 1986-05-06 1990-02-02 Roussel Uclaf Nouveaux vecteurs d'expression, leur procede d'obtention et leur application pour exprimer une proteine quelconque dans escherichia coli
DK6488D0 (da) * 1988-01-07 1988-01-07 Novo Industri As Enzymer
PT89702B (pt) * 1988-02-11 1994-04-29 Gist Brocades Nv Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem
DK316989D0 (da) * 1989-06-26 1989-06-26 Novo Nordisk As Enzymer

Also Published As

Publication number Publication date
DE59010522D1 (de) 1996-11-07
JPH03139277A (ja) 1991-06-13
EP0415296A3 (en) 1991-10-02
DK0415296T3 (da) 1996-11-18
DE4023458A1 (de) 1991-03-07
ES2093624T5 (es) 2001-08-16
EP0415296A2 (de) 1991-03-06
EP0415296B1 (de) 1996-10-02
KR100196785B1 (ko) 1999-06-15
KR910004806A (ko) 1991-03-29
ATE143689T1 (de) 1996-10-15
EP0415296B2 (de) 2001-04-25
ES2093624T3 (es) 1997-01-01

Similar Documents

Publication Publication Date Title
DK0415296T3 (da) Nye højalkaliske proteaser
JP4086207B2 (ja) ズブチリシン変異体
BG89942A (bg) Метод за получаване на протеолитични ензими
DE69635444D1 (de) Gereinigte coprinus laccasen und nukleinsäuren welche dafür kodieren
BR9007477A (pt) Protease de subtilisina mutante e processo para a determinacao ou selecao da(s)posicao(oes)e do(s)aminoacido(s)a remover,substituir ou inserir no lugar do(s)aminoacido(s)da enzima mae
ES2125224T3 (es) Mutantes de subtilisina.
FI20031199A (fi) Stabiileja bakterisidisia/läpäisevyyttä parantavia proteiinituotteita ja näitä sisältäviä farmaseuttisia koostumuksia
ID27693A (id) RANGKAIAN-RANGKAIAN NUKLEOTIDA YANG MENGKODE GEN pck
EA200100419A1 (ru) Трансформационная система в области грибов гифомицетов-хозяев
KR930703438A (ko) pH의 범위에 걸쳐 낮은 분자전위의 변이도를 갖는 효소돌연변이체
DK1294888T3 (da) Interferonlignende protein Zcyto21
AU1003888A (en) Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host, process, expression vector and recombinant host therefore and pharmaceutical use thereof
BR9104613A (pt) Protease,sequencia de dna,vetor de expressao,transformante,metodo de producao de protease
DK0870833T3 (da) Gener for ultrathermostabile proteaser
DK0574347T3 (da) Hidtil ukendt svampeprotease
NO944181D0 (no) Proteaser for sopp
AU665935B2 (en) Thrombolytic peptide, production thereof and thrombolytic agent
MX9401068A (es) Mejoras en proteasa muy alcalinas que presentan una secuencia de aminoacidos.
Vetter et al. Highly alkaline proteases
EP0945512A3 (en) Novel serine proteases
AU3524593A (en) Mutation of the rhinovirus system