DK0413516T3 - 4-Methylen-1-oxa-2-oxo-8-azaspiro(4,5)-decanderivater fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf - Google Patents

4-Methylen-1-oxa-2-oxo-8-azaspiro(4,5)-decanderivater fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf

Info

Publication number
DK0413516T3
DK0413516T3 DK90308783.1T DK90308783T DK0413516T3 DK 0413516 T3 DK0413516 T3 DK 0413516T3 DK 90308783 T DK90308783 T DK 90308783T DK 0413516 T3 DK0413516 T3 DK 0413516T3
Authority
DK
Denmark
Prior art keywords
alkyl
azaspiro
oxa
oxo
methylene
Prior art date
Application number
DK90308783.1T
Other languages
Danish (da)
English (en)
Inventor
Eva Dr Palosi
Dora Dr Groo
Bela Kiss
Jozsef Toerley
Istvan Dr Laszlovszky
Erzsebet Dr Lapis
Ferenc Auth
Laszlo Dr Gaal
Edit Toth
Laszlo Dr Szporny
Sandor Dr Goeroeg
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of DK0413516T3 publication Critical patent/DK0413516T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
DK90308783.1T 1989-08-10 1990-08-09 4-Methylen-1-oxa-2-oxo-8-azaspiro(4,5)-decanderivater fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf DK0413516T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU894094A HU204276B (en) 1989-08-10 1989-08-10 Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
DK0413516T3 true DK0413516T3 (da) 1994-05-24

Family

ID=10966866

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90308783.1T DK0413516T3 (da) 1989-08-10 1990-08-09 4-Methylen-1-oxa-2-oxo-8-azaspiro(4,5)-decanderivater fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf

Country Status (26)

Country Link
US (2) US5132303A (fr)
EP (2) EP0413516B1 (fr)
JP (2) JPH0381277A (fr)
KR (2) KR940002826B1 (fr)
CN (1) CN1025031C (fr)
AT (2) ATE113951T1 (fr)
AU (2) AU621771B2 (fr)
CA (2) CA2023018C (fr)
DD (2) DD299428A5 (fr)
DE (2) DE69008275T2 (fr)
DK (1) DK0413516T3 (fr)
ES (2) ES2052179T3 (fr)
FI (1) FI93456C (fr)
HK (1) HK118295A (fr)
HU (2) HU204276B (fr)
IE (1) IE902885A1 (fr)
IL (2) IL95324A (fr)
IN (1) IN170979B (fr)
IS (1) IS3612A7 (fr)
MY (1) MY107240A (fr)
NO (1) NO903511L (fr)
NZ (2) NZ234846A (fr)
PL (2) PL164662B1 (fr)
SG (1) SG59864G (fr)
YU (2) YU150489A (fr)
ZA (3) ZA906300B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2608079B2 (ja) * 1986-12-17 1997-05-07 グラクソ、グループ、リミテッド 医 薬
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
EP0492020A1 (fr) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Utilisation de certains esters de la hexahydro-8-hydroxy-2,6-méthano-2H-quinolizine-3(4H)-one et des composés apparentés pour le traitement des maladies cognitives
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!
US6100256A (en) * 1996-12-02 2000-08-08 Merck Sharp & Dohme Ltd. Use of NK-1 receptors antagonists for treating schizophrenic disorders
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
KR20030087248A (ko) * 2002-05-08 2003-11-14 (주)씨엔아이 온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
EP2443124B1 (fr) * 2009-06-16 2014-01-22 Merck Sharp & Dohme Corp. 1,3,8-triazaspiro[4,5]décane-2,4-diones substituées
GB201416352D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
GB201416346D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127065C (fr) * 1964-04-22
CH601304A5 (fr) * 1974-02-12 1978-07-14 Buskine Sa
BE790675A (fr) * 1971-10-29 1973-04-27 Science Union & Cie Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
HU204530B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost

Also Published As

Publication number Publication date
NO903511L (no) 1991-02-11
PL291648A1 (en) 1992-06-01
PL163899B1 (pl) 1994-05-31
IL95324A0 (en) 1991-06-30
DE69008275D1 (de) 1994-05-26
KR910004631A (ko) 1991-03-29
YU150489A (sh) 1992-12-21
EP0412821A3 (en) 1991-11-27
KR940002826B1 (ko) 1994-04-04
HU903233D0 (en) 1990-10-28
CA2023018C (fr) 1995-11-28
CA2023015A1 (fr) 1991-02-11
DE69014008T2 (de) 1995-03-23
HUT59375A (en) 1992-05-28
PL286443A1 (en) 1992-01-13
AU621771B2 (en) 1992-03-19
DE69008275T2 (de) 1994-08-04
JPH0381277A (ja) 1991-04-05
KR910004630A (ko) 1991-03-29
EP0412821B1 (fr) 1994-11-09
ES2052179T3 (es) 1994-07-01
US5132303A (en) 1992-07-21
EP0413516A2 (fr) 1991-02-20
IL95325A (en) 1994-06-24
AU6080490A (en) 1991-02-14
IL95324A (en) 1994-02-27
HU204276B (en) 1991-12-30
ES2063923T3 (es) 1995-01-16
EP0413516A3 (en) 1991-11-27
ATE104671T1 (de) 1994-05-15
HU206677B (en) 1992-12-28
CN1049349A (zh) 1991-02-20
IN170979B (fr) 1992-06-27
HK118295A (en) 1995-07-28
AU621238B2 (en) 1992-03-05
KR940000830B1 (ko) 1994-02-02
MY107240A (en) 1995-10-31
DE69014008D1 (de) 1994-12-15
DD299431A5 (de) 1992-04-16
ATE113951T1 (de) 1994-11-15
ZA906304B (en) 1991-06-26
FI93456C (fi) 1995-04-10
JPH0383985A (ja) 1991-04-09
US5132309A (en) 1992-07-21
CA2023018A1 (fr) 1991-02-11
FI93456B (fi) 1994-12-30
NZ234846A (en) 1992-03-26
NO903511D0 (no) 1990-08-09
HUT55785A (en) 1991-06-28
AU6080390A (en) 1991-02-14
SG59864G (en) 1995-09-01
IE902885A1 (en) 1991-02-27
DD299428A5 (de) 1992-04-16
IL95325A0 (en) 1991-06-30
EP0412821A2 (fr) 1991-02-13
EP0413516B1 (fr) 1994-04-20
IS3612A7 (is) 1991-02-11
ZA906300B (en) 1991-05-29
FI903974A0 (fi) 1990-08-10
PL164662B1 (pl) 1994-09-30
YU154090A (sh) 1992-12-21
CN1025031C (zh) 1994-06-15
ZA906299B (en) 1991-06-26
NZ234843A (en) 1992-03-26

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