CA2023018A1 - Derives de 2-oxo-3,8-diazaspiro/4,5/decane, composes pharmaceutiques les contenant et procede de preparation - Google Patents
Derives de 2-oxo-3,8-diazaspiro/4,5/decane, composes pharmaceutiques les contenant et procede de preparationInfo
- Publication number
- CA2023018A1 CA2023018A1 CA2023018A CA2023018A CA2023018A1 CA 2023018 A1 CA2023018 A1 CA 2023018A1 CA 2023018 A CA2023018 A CA 2023018A CA 2023018 A CA2023018 A CA 2023018A CA 2023018 A1 CA2023018 A1 CA 2023018A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- 4alkyl
- same
- diazaspiro
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU894094A HU204276B (en) | 1989-08-10 | 1989-08-10 | Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
HU4094/89 | 1989-08-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2023018A1 true CA2023018A1 (fr) | 1991-02-11 |
CA2023018C CA2023018C (fr) | 1995-11-28 |
Family
ID=10966866
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002023015A Abandoned CA2023015A1 (fr) | 1989-08-10 | 1990-08-09 | Dejrives de 4-methylene-2-oxo-8-azaspiro/4,5/decane, composes pharmaceutiques les contenant et procede de preparation |
CA002023018A Expired - Fee Related CA2023018C (fr) | 1989-08-10 | 1990-08-09 | Derives de 2-oxo-3,8-diazaspiro/4,5/decane, composes pharmaceutiques les contenant et procede de preparation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002023015A Abandoned CA2023015A1 (fr) | 1989-08-10 | 1990-08-09 | Dejrives de 4-methylene-2-oxo-8-azaspiro/4,5/decane, composes pharmaceutiques les contenant et procede de preparation |
Country Status (26)
Country | Link |
---|---|
US (2) | US5132309A (fr) |
EP (2) | EP0413516B1 (fr) |
JP (2) | JPH0381277A (fr) |
KR (2) | KR940002826B1 (fr) |
CN (1) | CN1025031C (fr) |
AT (2) | ATE113951T1 (fr) |
AU (2) | AU621238B2 (fr) |
CA (2) | CA2023015A1 (fr) |
DD (2) | DD299431A5 (fr) |
DE (2) | DE69014008T2 (fr) |
DK (1) | DK0413516T3 (fr) |
ES (2) | ES2052179T3 (fr) |
FI (1) | FI93456C (fr) |
HK (1) | HK118295A (fr) |
HU (2) | HU204276B (fr) |
IE (1) | IE902885A1 (fr) |
IL (2) | IL95324A (fr) |
IN (1) | IN170979B (fr) |
IS (1) | IS3612A7 (fr) |
MY (1) | MY107240A (fr) |
NO (1) | NO903511L (fr) |
NZ (2) | NZ234843A (fr) |
PL (2) | PL163899B1 (fr) |
SG (1) | SG59864G (fr) |
YU (2) | YU150489A (fr) |
ZA (3) | ZA906300B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4985437A (en) * | 1986-12-17 | 1991-01-15 | Glaxo Group Limited | Medicaments |
YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
HU204529B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
EP0492020A1 (fr) * | 1990-12-21 | 1992-07-01 | Merrell Dow Pharmaceuticals Inc. | Utilisation de certains esters de la hexahydro-8-hydroxy-2,6-méthano-2H-quinolizine-3(4H)-one et des composés apparentés pour le traitement des maladies cognitives |
GB9206989D0 (en) * | 1992-03-31 | 1992-05-13 | Glaxo Group Ltd | Chemical compounds |
US5756743A (en) * | 1996-04-10 | 1998-05-26 | Hoechst Marion Roussel Inc. | Spiro cyclopent b!indole-piperidines! |
US6100256A (en) * | 1996-12-02 | 2000-08-08 | Merck Sharp & Dohme Ltd. | Use of NK-1 receptors antagonists for treating schizophrenic disorders |
US6974825B1 (en) | 1996-12-20 | 2005-12-13 | Astrazeneca Canada Inc. | Compounds with analgesic effect |
SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE0101771D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101773D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101769D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101770D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
KR20030087248A (ko) * | 2002-05-08 | 2003-11-14 | (주)씨엔아이 | 온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치 |
US8921555B2 (en) * | 2009-06-16 | 2014-12-30 | Merck Sharp & Dohme Corp. | Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones |
GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
GB201416352D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL127065C (fr) * | 1964-04-22 | |||
CH601304A5 (fr) * | 1974-02-12 | 1978-07-14 | Buskine Sa | |
BE790675A (fr) * | 1971-10-29 | 1973-04-27 | Science Union & Cie | Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane |
FR2615515B1 (fr) * | 1987-05-22 | 1989-06-30 | Adir | Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant |
YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
HU204529B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
HU204530B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
-
1989
- 1989-07-27 YU YU150489A patent/YU150489A/sh unknown
- 1989-08-10 HU HU894094A patent/HU204276B/hu not_active IP Right Cessation
- 1989-08-10 HU HU903233A patent/HU206677B/hu not_active IP Right Cessation
-
1990
- 1990-08-08 KR KR1019900012168A patent/KR940002826B1/ko not_active IP Right Cessation
- 1990-08-08 KR KR1019900012169A patent/KR940000830B1/ko not_active IP Right Cessation
- 1990-08-09 EP EP90308783A patent/EP0413516B1/fr not_active Expired - Lifetime
- 1990-08-09 NZ NZ234843A patent/NZ234843A/en unknown
- 1990-08-09 NO NO90903511A patent/NO903511L/no unknown
- 1990-08-09 AT AT90308779T patent/ATE113951T1/de not_active IP Right Cessation
- 1990-08-09 IS IS3612A patent/IS3612A7/is unknown
- 1990-08-09 ZA ZA906300A patent/ZA906300B/xx unknown
- 1990-08-09 AU AU60804/90A patent/AU621238B2/en not_active Ceased
- 1990-08-09 NZ NZ234846A patent/NZ234846A/en unknown
- 1990-08-09 DK DK90308783.1T patent/DK0413516T3/da active
- 1990-08-09 AU AU60803/90A patent/AU621771B2/en not_active Ceased
- 1990-08-09 SG SG1995903969A patent/SG59864G/en unknown
- 1990-08-09 IL IL9532490A patent/IL95324A/en not_active IP Right Cessation
- 1990-08-09 DD DD90343359A patent/DD299431A5/de not_active IP Right Cessation
- 1990-08-09 IL IL9532590A patent/IL95325A/en not_active IP Right Cessation
- 1990-08-09 AT AT9090308783T patent/ATE104671T1/de not_active IP Right Cessation
- 1990-08-09 DE DE69014008T patent/DE69014008T2/de not_active Expired - Fee Related
- 1990-08-09 EP EP90308779A patent/EP0412821B1/fr not_active Expired - Lifetime
- 1990-08-09 JP JP2209362A patent/JPH0381277A/ja active Pending
- 1990-08-09 CA CA002023015A patent/CA2023015A1/fr not_active Abandoned
- 1990-08-09 CA CA002023018A patent/CA2023018C/fr not_active Expired - Fee Related
- 1990-08-09 YU YU154090A patent/YU154090A/sh unknown
- 1990-08-09 ZA ZA906299A patent/ZA906299B/xx unknown
- 1990-08-09 IE IE288590A patent/IE902885A1/en unknown
- 1990-08-09 DE DE69008275T patent/DE69008275T2/de not_active Expired - Fee Related
- 1990-08-09 ES ES90308783T patent/ES2052179T3/es not_active Expired - Lifetime
- 1990-08-09 ES ES90308779T patent/ES2063923T3/es not_active Expired - Lifetime
- 1990-08-09 DD DD90343354A patent/DD299428A5/de not_active IP Right Cessation
- 1990-08-09 ZA ZA906304A patent/ZA906304B/xx unknown
- 1990-08-09 IN IN687/CAL/90A patent/IN170979B/en unknown
- 1990-08-09 JP JP2209363A patent/JPH0383985A/ja active Pending
- 1990-08-10 PL PL90286443A patent/PL163899B1/pl unknown
- 1990-08-10 CN CN90106974A patent/CN1025031C/zh not_active Expired - Fee Related
- 1990-08-10 US US07/566,279 patent/US5132309A/en not_active Expired - Fee Related
- 1990-08-10 PL PL90291648A patent/PL164662B1/pl unknown
- 1990-08-10 US US07/566,278 patent/US5132303A/en not_active Expired - Fee Related
- 1990-08-10 FI FI903974A patent/FI93456C/fi not_active IP Right Cessation
- 1990-08-10 MY MYPI90001343A patent/MY107240A/en unknown
-
1995
- 1995-07-20 HK HK118295A patent/HK118295A/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2023018A1 (fr) | Derives de 2-oxo-3,8-diazaspiro/4,5/decane, composes pharmaceutiques les contenant et procede de preparation | |
GR3018387T3 (en) | Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them. | |
ES8706670A1 (es) | Un procedimiento para preparar 1,4-dihidropiridinas | |
ES8602033A1 (es) | Un procedimiento para preparar derivados de adenosina. | |
KR100271416B1 (en) | Carbamate derivatives of 4-amino-3-isoxazolidinones,3-amino-1-hydroxypyrrolidin-2-ones and1-amino-1-cyclopropanecarboxylic acid analogs, aprocess for their preparation and a pharmaceuticalcomposition comprising the same | |
RU94046141A (ru) | Замещенные производные /арилалкоксибензил/ аминопропанамида, способы их получения, фармацевтическая композиция | |
HUT53354A (en) | Process for producing substituted 2-amino-1,2,3,4-tetrahydronaphthalene and 3-aminochromane derivatives | |
AU2522692A (en) | Imidazol-1-yl methyl pyridine derivatives, processes for their production and their use as pharmaceuticals | |
AU7216087A (en) | Benzhydrylpiperazine derivatives, pharmaceutical compositions containing them and process for preparing same | |
ES2009689A6 (es) | Procedimiento para preparar derivados de 3-piperidina-carbaldehido-oxima. | |
NZ228182A (en) | Substituted 4,5,6,7-tetrahydroisothiazolo(4,5-c) pyridine derivatives and pharmaceutical compositions; methods for preparation | |
IE873212L (en) | Medicaments based on derivatives of 3,4-di-phenylpiperidine,¹the use of the derivatives as medicaments, and novel¹3,4-diphenylpiperidine derivatives and a process for the¹preparation therefor | |
NZ233728A (en) | Amino acid compounds and pharmaceutical compositions thereof | |
ES8101646A1 (es) | Un procedimiento para producir un compuesto opticamente ac- tivo | |
MY107125A (en) | Novel 2-oxo-1-oxa-8-azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and process for preparing same. | |
ES8704463A1 (es) | Procedimiento para preparar 2-(n-alquinil-n-fenilamino)-imidazolinas | |
ATE147075T1 (de) | Purinverbindungen, verfahren zu ihrer herstellung, pharmazeutische präparate und zwischenverbindungen | |
DE3378980D1 (en) | Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds | |
ES8401062A1 (es) | Procedimiento para la preparacion de nuevas 1-furil-3,4-dihidroisoquinoleinas. | |
ATE36154T1 (de) | 4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. | |
EP0424528A4 (en) | Phenylalkanoylamine derivatives, process for their preparation, and their uses |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |