DK0381514T3 - Anvendelse af N-methyl-sphingosin som inhibitor for cellevækst - Google Patents

Anvendelse af N-methyl-sphingosin som inhibitor for cellevækst

Info

Publication number
DK0381514T3
DK0381514T3 DK90301099.9T DK90301099T DK0381514T3 DK 0381514 T3 DK0381514 T3 DK 0381514T3 DK 90301099 T DK90301099 T DK 90301099T DK 0381514 T3 DK0381514 T3 DK 0381514T3
Authority
DK
Denmark
Prior art keywords
sphingosine
methyl
pharmaceutically acceptable
prepared
growth
Prior art date
Application number
DK90301099.9T
Other languages
Danish (da)
English (en)
Inventor
Sen-Itiroh Hakomori
Yasuyuki Igarashi
Tatsushi Toyokuni
Efraim Racker
Shuji Fujita
Mamoru Sugimoto
Masayoshi Ito
Yoshiyasu Shitori
Tomoya Ogawa
Original Assignee
Biomembrane Inst
Cornell Res Foundation Inc
Kanto Ishi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomembrane Inst, Cornell Res Foundation Inc, Kanto Ishi Pharma Co Ltd filed Critical Biomembrane Inst
Application granted granted Critical
Publication of DK0381514T3 publication Critical patent/DK0381514T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK90301099.9T 1989-02-03 1990-02-02 Anvendelse af N-methyl-sphingosin som inhibitor for cellevækst DK0381514T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30637889A 1989-02-03 1989-02-03
US39013589A 1989-08-07 1989-08-07

Publications (1)

Publication Number Publication Date
DK0381514T3 true DK0381514T3 (da) 1995-09-04

Family

ID=26975128

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90301099.9T DK0381514T3 (da) 1989-02-03 1990-02-02 Anvendelse af N-methyl-sphingosin som inhibitor for cellevækst

Country Status (6)

Country Link
EP (1) EP0381514B1 (de)
JP (1) JP2976055B2 (de)
AT (1) ATE122560T1 (de)
CA (1) CA2007507C (de)
DE (1) DE69019388T2 (de)
DK (1) DK0381514T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583160A (en) * 1989-02-03 1996-12-10 The Biomembrane Institute Methylsphingosine used to treat apoptosis
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
US5260288A (en) * 1992-04-03 1993-11-09 The Biomembrane Institute Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives
IL121320A (en) 1997-02-23 2000-12-06 Ibr Ltd Extracts from cells or tissue of organisms which are capable of entering dormancy for inhibition of proliferation of target cells or tissue
US6107520A (en) * 1997-04-15 2000-08-22 The Board Of Trustees Of The University Of Illinois Spisulosine compounds
USRE38793E1 (en) 1997-04-15 2005-09-06 Rinehart Kenneth L Spisulosine compounds
US6800661B1 (en) 1997-04-15 2004-10-05 Board Of Trustees Of The University Of Illinois Spisulosine compounds
US6649362B2 (en) 1997-09-08 2003-11-18 Medvet Science Pty. Ltd. Screening method for an agent having an effect on a sphingosine kinase signaling pathway
AUPO900297A0 (en) * 1997-09-08 1997-10-02 Medvet Science Pty. Ltd. A method of modulating cellular activity
AU3387301A (en) * 2000-02-16 2001-08-27 Pharma Mar Sa Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity
EP1195604A1 (de) * 2000-09-29 2002-04-10 Warner-Lambert Company Verfahren und Zusammensetzungen zum Screenen von Modulatoren von Lipidkinasen
WO2002060405A1 (en) * 2001-01-29 2002-08-08 Cosmoferm B.V. Veterinary dermatologic composition comprising a sphingoid base and/or a sphingoid base derivative
KR100457113B1 (ko) * 2001-12-27 2004-11-16 한국원자력연구소 세라마이드류 또는 그 유도체와 다이메틸스핑고신을 유효성분으로 포함하는 방사선민감도 증진제
KR100459484B1 (ko) * 2002-05-20 2004-12-03 한국원자력연구소 엔-아세틸 파이토스핑고신과 다이메틸 파이토스핑고신을유효 성분으로 포함하는 방사선 치료 민감제 조성물
EP1426053A1 (de) * 2002-12-03 2004-06-09 Fresenius Kabi Deutschland GmbH Verwendung von amphiphilen Lipiden zur Hemmung von Tumormetastasierung
AU2005310341A1 (en) 2004-11-30 2006-06-08 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae
US20110152267A1 (en) * 2009-11-12 2011-06-23 Texas Tech University System Compositions and Methods for Treating Hyperproliferative Disorders
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases

Also Published As

Publication number Publication date
EP0381514A2 (de) 1990-08-08
DE69019388T2 (de) 1996-01-04
ATE122560T1 (de) 1995-06-15
EP0381514B1 (de) 1995-05-17
CA2007507A1 (en) 1990-08-03
EP0381514A3 (de) 1991-07-17
JP2976055B2 (ja) 1999-11-10
CA2007507C (en) 1998-05-19
DE69019388D1 (de) 1995-06-22
JPH03157336A (ja) 1991-07-05

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