DE897145C - Method of making a remedy from butterbur - Google Patents

Method of making a remedy from butterbur

Info

Publication number
DE897145C
DE897145C DER7464A DER0007464A DE897145C DE 897145 C DE897145 C DE 897145C DE R7464 A DER7464 A DE R7464A DE R0007464 A DER0007464 A DE R0007464A DE 897145 C DE897145 C DE 897145C
Authority
DE
Germany
Prior art keywords
butterbur
remedy
making
concentration
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DER7464A
Other languages
German (de)
Inventor
Ernst Riedweg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE897145C publication Critical patent/DE897145C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Fats And Perfumes (AREA)
  • Medicines Containing Plant Substances (AREA)

Description

Verfahren zur Herstellung eines Heilmittels aus Pestwurz Gegenstand der Erfindung ist ein Verfahren zur Herstellung eines Heilmittels aus Pestwurz (radix petasitidis officinalis), welches dadurch gekennzeichnet ist, daß man Pestwurz mit Methanol extrahiert, den erhaltenen sauren Auszug durch Zusatz von Alkali alkalisch macht, aus der alkalischen Lösung durch Zusatz von Aceton die wirksame Substanz ausfällt und den erhaltenen Niederschlag trocknet.Method of making a remedy from butterbur object The invention is a method of making a remedy from butterbur (radix petasitidis officinalis), which is characterized by the fact that butterbur is mixed with Methanol extracted, the acid extract obtained alkaline by adding alkali turns the alkaline solution into the active substance by adding acetone precipitates and the resulting precipitate dries.

Das erhaltene Produkt zeigt starke spasmolytische Wirksamkeit. Es war bisher nicht bekannt, daß Pestwurz ein Spasmolytikum enthält. The product obtained shows strong spasmolytic activity. It was not previously known that butterbur contains an antispasmodic.

Beispiel I kg Pestwurz wird mit 1112 kg Methanol extrahiert und dem erhaltenen, sauer reagierenden Extrakt so viel Alkali zugesetzt, daß er ein PH von g aufweist. Bei Zusatz von 400 cm3 Aceton fallen weiße Plocken aus. Example I kg butterbur is extracted with 1112 kg methanol and the obtained acidic extract added so much alkali that it has a pH of g. When 400 cm3 of acetone are added, white flakes precipitate.

Die überstehende Flüssigkeit wird abdekantiert, und die Flocken werden eingetrocknet. Man erhält so eine erste Ausbeute von etwa 2 0/o.The supernatant liquid is decanted off and the flakes are dried up. An initial yield of about 2% is obtained in this way.

Der flüssige, alkalische Rückstand wird so weit angesäuert, daß er ein PH von 5,5 bis 6 aufweist, und dann pro Liter mit zl/2-l Äther versetzt. Es fallen wiederum weiße Flocken aus in einer Ausbeute von etwa 4010. Die überstehende Flüssigkeit wird zur Trockne verdampft, wobei nochmals ein gewisses Quantum wirksamer Substanz erhalten wird. The liquid, alkaline residue is acidified to such an extent that it has a pH of 5.5 to 6, and then added zl / 2-l of ether per liter. It turn out white flakes in a yield of about 4010. The protruding Liquid is evaporated to dryness, again being a certain amount more effective Substance is obtained.

Von Pharmakologen angestellte Versuche mit dem erhaltenen Produkt ergaben folgendes: Bei einem Meerschweinchen wurde durch Einwirkung von Histamindihydrochlorid in Konzentration von 5Io-8 eine Darmkontraktur hervorgerufen. Diese Kontraktur konnte behoben werden: I. mit dem Produkt des ersten Arbeitsganges des Beispiels in einer Konzen- tration von 5.Io-U, 2. mit dem Rückstand aus diesem Arbeitsgang in einer Konzentration von 2.IO4, 3. mit dem verarbeiteten Rückstand (2. Arbeitsgang des Beispiels) in einer Konzentration von I.IO3, 4. mit dem Produkt aus dem 3. Arbeitsgang des Beispiels in einer Konzentration von 5.IO6, 5. mit dem Gesamtprodukt des im Beispiel beschriebenen Verfahrens in einer Konzentration von PATENTANSPR jJCHE I. Verfahren zur Herstellung eines Heilmittels aus Pestwurz, dadurch gekennzeichnet, daß man Pestwurz mit Methanol extrahiert, den erhaltenen sauren Auszug durch Zusatz von Alkali alkalisch macht, aus der alkalischen Lösung durch Zusatz von Aceton die wirksame Substanz ausfällt und den erhaltenen Niederschlag trocknet. Tests carried out by pharmacologists on the product obtained found the following: In a guinea pig, the action of histamine dihydrochloride caused an intestinal contracture in a concentration of 5Io-8. This contracture could be corrected: I. with the product of the first operation of the example in one Concentration tration of 5.Io-U, 2. with the residue from this operation in a concentration of 2.IO4, 3. with the processed residue (2. work step of the example) in a concentration of I.IO3, 4th with the product from the 3rd operation of the example in a concentration of 5.IO6, 5. with the total product of the im Example described method in a concentration of PATENT CLAIM jJCHE I. Process for the production of a remedy from butterbur, characterized in, that butterbur is extracted with methanol, the acid extract obtained by addition of alkali makes the alkaline solution alkaline by adding acetone active substance precipitates and the resulting precipitate dries.

Claims (1)

2. Verfahren nach Anspruch I, dadurch gekennzeichnet, daß man den nach der Ausfällung mit Aceton erhaltenen flüssigen Rückstand bis auf ein pH von 5,5 bis 6 ansäuert, mit Äther versetzt und die über dem gebildeten, aus wirksamer Substanz bestehenden Niederschlag stehende Flüssigkeit zur Trockne verdampft, wobei nochmals wirksame Substanz erhalten wird. 2. The method according to claim I, characterized in that the liquid residue obtained after precipitation with acetone down to a pH of 5.5 to 6 acidified, mixed with ether and those formed above, from more effective Substance existing precipitate, standing liquid evaporated to dryness, whereby again active substance is obtained. Angezogene Druckschriften: Thoms, Handbuch d. Pharmazie, Bd. V, S. I678 und I680; schweizerische Patentschrift Nr. 228 340. Printed publications: Thoms, Handbuch d. Pharmacy, Vol. V, p. I678 and I680; Swiss patent specification No. 228 340.
DER7464A 1950-11-09 1951-10-26 Method of making a remedy from butterbur Expired DE897145C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH897145X 1950-11-09

Publications (1)

Publication Number Publication Date
DE897145C true DE897145C (en) 1953-11-19

Family

ID=4546315

Family Applications (1)

Application Number Title Priority Date Filing Date
DER7464A Expired DE897145C (en) 1950-11-09 1951-10-26 Method of making a remedy from butterbur

Country Status (1)

Country Link
DE (1) DE897145C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281656A1 (en) * 1987-03-12 1988-09-14 Plantamed Arzneimittel GmbH Use of petasite extracts in the preparation of a medicine for the treatment of gastrointestinal diseases
EP0547465A1 (en) * 1991-12-14 1993-06-23 WEBER & WEBER GmbH Process of preparation of extracts of Petasites rhizomas

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH228340A (en) * 1942-08-12 1943-08-15 Schaub & Niederhaeusern Process for the production of a therapeutically effective preparation.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH228340A (en) * 1942-08-12 1943-08-15 Schaub & Niederhaeusern Process for the production of a therapeutically effective preparation.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281656A1 (en) * 1987-03-12 1988-09-14 Plantamed Arzneimittel GmbH Use of petasite extracts in the preparation of a medicine for the treatment of gastrointestinal diseases
EP0547465A1 (en) * 1991-12-14 1993-06-23 WEBER & WEBER GmbH Process of preparation of extracts of Petasites rhizomas

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