DE473151C - Process for obtaining total alkaloids from ergot - Google Patents

Process for obtaining total alkaloids from ergot

Info

Publication number
DE473151C
DE473151C DEST40748D DEST040748D DE473151C DE 473151 C DE473151 C DE 473151C DE ST40748 D DEST40748 D DE ST40748D DE ST040748 D DEST040748 D DE ST040748D DE 473151 C DE473151 C DE 473151C
Authority
DE
Germany
Prior art keywords
ergot
alkaloids
total alkaloids
obtaining total
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEST40748D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to DEST40748D priority Critical patent/DE473151C/en
Application granted granted Critical
Publication of DE473151C publication Critical patent/DE473151C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G5/00—Alkaloids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Description

Verfahren zur Gewinnung der Gesamtalkaloide aus 1Kutterkorn Durch das Hauptpatent 439 042 ist ein Verfahren geschützt, mit -dessen Hilfe es möglich ist, die Alkaloide aus dem Mutterkorn ohne die sonst übliche vorherige Entfettung herauszulösen und in- einem Arbeitsgange fettfrei zu gewinnen.Process for obtaining the total alkaloids from 1Kutterkorn Avg the main patent 439 042 is a process protected, with the help of which it is possible is, the alkaloids from ergot without the usual prior degreasing to be extracted and to be extracted fat-free in one operation.

Es wurde nun festgestellt, daB es möglich ist, das im Hauptpatent verwendete Aceton durch 45- bis 6oprozentigen Äthylalkohol zu ersetzen und mit diesem Lösungsmittel ein gleich günstiges Ergebnis zu erzielen. Im übrigen wird dasVerfahren in analogerWeise wie dasjenige des Hauptpatentes durchgeführt.It has now been found that it is possible to do so in the main patent used to replace acetone with 45 to 6 percent ethyl alcohol and with this Solvent to achieve an equally favorable result. Otherwise the procedure is carried out in a manner analogous to that of the main patent.

Alkohol der angegebenen Konzentration wurde bis jetzt nur zur Gewinnung von Mutterkornextrakten, nicht aber zur Abscheidung der Alkaloide verwendet. Die älteren Untersucher haben aber die Bedeutung, welche die Löslichkeit der Alkaloide in verdünntem Alkohol für die Abscheidung besitzt, nicht erkannt, sondern im Gegenteil diejenigen Stoffe, welche bei der Entfernung oder Verdünnung des Alkohols ausfallen, entfernt und das Filtrat zur Gewinnung des Extraktes weiterverarbeitet. Bei dieser Arbeitsweise gehen aber erhebliche Mengen der Alkaloide verloren, die nach dem neuen Verfahren gewonnen werden.Alcohol of the stated concentration has only been used for extraction until now from ergot extracts, but not used to separate the alkaloids. the but older investigators have the importance of the solubility of the alkaloids possesses in dilute alcohol for the deposition, not recognized, but on the contrary those substances which precipitate when the alcohol is removed or diluted, removed and the filtrate processed to obtain the extract. At this However, considerable amounts of the alkaloids are lost after the new one works Procedure can be obtained.

Beispiel i kg gemahlenes Mutterkorn wird mit 2i', Liter einer Mischung von gleichen Teilen Alkohol und Wasser pereoliert.Example 1 kg of ground ergot is mixed with 2½ liters pereolated from equal parts of alcohol and water.

Das fettfreie Percolat reagiert stark sauer. Durch allmählich erfolgenden Zusatz von 40 bis 5o ccm ioprozentiger Natronlauge wird die Säure so weit abgestumpft, daß nach dreistündigem Stehen eine nur ganz schwach saure Reaktion bestehen bleibt.The fat-free percolate reacts strongly acidic. By gradually occurring The addition of 40 to 50 ccm of 10% sodium hydroxide solution will dull the acid to such an extent that that after standing for three hours a very weakly acidic reaction persists.

Aus dem Percolat wird der Alkohol durch Destillation im Vakuum bei niederer Temperatur verjagt. Hierbei scheidet sich ein in Wasser unlöslicher, hellbrauner, flockiger Niederschlag aus, der die gesamten Alkaloide enthält. Er wird abfiltriert, ausgewaschen und getrocknet. Ausbeute an Rohalkaloid 7e2 g.The alcohol is expelled from the percolate by distillation in vacuo at a low temperature. A light brown, flaky precipitate, which is insoluble in water and contains all of the alkaloids, separates out. It is filtered off, washed and dried. Yield of crude alkaloid 7e2 g.

Das so gewonnene Rohprodukt kann nach den bekannten Alkaloidreinigungsmethoden in reines Alkaloidpräparat übergeführt werden. Ausbeute ungefähr o,8 g.The crude product obtained in this way can be purified by the known alkaloid cleaning methods be converted into a pure alkaloid preparation. Yield about 0.8 g.

Claims (1)

PATENTANSPRUCH: Abänderung des durch Patent 439 042 geschützten Verfahrens zur Gewinnung !der Gesamtalkaloide haus Mutterkorn, 'darin bestehend, daB man an Stelle von Aceton 45- bis 6oprozentigen Äthylalkohol als Lösungsmittel verwendet und die in die Lösung gegangenen Alkaloide durch Entfernung des Äthylalkohols zur Abscheidung bringt.PATENT CLAIM: Modification of the process, protected by patent 439 042 , for the production of total alkaloids from ergot, consisting in using 45 to 6 percent ethyl alcohol as a solvent instead of acetone and separating the alkaloids that have gone into solution by removing the ethyl alcohol .
DEST40748D 1926-03-18 1926-03-18 Process for obtaining total alkaloids from ergot Expired DE473151C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEST40748D DE473151C (en) 1926-03-18 1926-03-18 Process for obtaining total alkaloids from ergot

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEST40748D DE473151C (en) 1926-03-18 1926-03-18 Process for obtaining total alkaloids from ergot

Publications (1)

Publication Number Publication Date
DE473151C true DE473151C (en) 1929-03-11

Family

ID=7463791

Family Applications (1)

Application Number Title Priority Date Filing Date
DEST40748D Expired DE473151C (en) 1926-03-18 1926-03-18 Process for obtaining total alkaloids from ergot

Country Status (1)

Country Link
DE (1) DE473151C (en)

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