DE841940T1 - Isolierung und/oder konservierung von dentritischen zellenfür die immuntherapie von prostatakrebs - Google Patents
Isolierung und/oder konservierung von dentritischen zellenfür die immuntherapie von prostatakrebsInfo
- Publication number
- DE841940T1 DE841940T1 DE0841940T DE96927268T DE841940T1 DE 841940 T1 DE841940 T1 DE 841940T1 DE 0841940 T DE0841940 T DE 0841940T DE 96927268 T DE96927268 T DE 96927268T DE 841940 T1 DE841940 T1 DE 841940T1
- Authority
- DE
- Germany
- Prior art keywords
- seq
- prostate cancer
- cells
- use according
- prostate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010060862 Prostate cancer Diseases 0.000 title claims 28
- 208000000236 Prostatic Neoplasms Diseases 0.000 title claims 28
- 238000009169 immunotherapy Methods 0.000 title 1
- 238000009413 insulation Methods 0.000 title 1
- 238000004321 preservation Methods 0.000 title 1
- 210000004443 dendritic cell Anatomy 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 8
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 8
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 6
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 239000006166 lysate Substances 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 5
- 208000023958 prostate neoplasm Diseases 0.000 claims 5
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 210000005259 peripheral blood Anatomy 0.000 claims 4
- 239000011886 peripheral blood Substances 0.000 claims 4
- 102000015728 Mucins Human genes 0.000 claims 3
- 108010063954 Mucins Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 210000002307 prostate Anatomy 0.000 claims 3
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 230000005907 cancer growth Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 210000001541 thymus gland Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229940126587 biotherapeutics Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001195—Prostate specific membrane antigen [PSMA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
- A61K40/4276—Prostate specific membrane antigen [PSMA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/58—Prostate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/509,254 US5788963A (en) | 1995-07-31 | 1995-07-31 | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| PCT/US1996/012389 WO1997004802A1 (en) | 1995-07-31 | 1996-07-29 | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE841940T1 true DE841940T1 (de) | 2001-08-23 |
Family
ID=24025874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0841940T Pending DE841940T1 (de) | 1995-07-31 | 1996-07-29 | Isolierung und/oder konservierung von dentritischen zellenfür die immuntherapie von prostatakrebs |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5788963A (enExample) |
| EP (2) | EP2377548A3 (enExample) |
| JP (1) | JP4267692B2 (enExample) |
| AU (1) | AU723607B2 (enExample) |
| CA (1) | CA2228176C (enExample) |
| DE (1) | DE841940T1 (enExample) |
| IL (1) | IL123079A0 (enExample) |
| NZ (1) | NZ315441A (enExample) |
| WO (1) | WO1997004802A1 (enExample) |
Families Citing this family (91)
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| WO1999043710A1 (en) * | 1998-02-26 | 1999-09-02 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
| WO1999046984A1 (en) * | 1998-03-20 | 1999-09-23 | Genzyme Corporation | Compositions and methods for the frozen storage of dendritic cells |
| CA2347067C (en) | 1998-03-31 | 2013-09-17 | Geron Corporation | Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer |
| US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
| WO1999058678A2 (en) * | 1998-05-11 | 1999-11-18 | Micromet Gmbh | Antibodies to dendritic cells and human dendritic cell populations and uses thereof |
| US7351546B2 (en) * | 1998-09-22 | 2008-04-01 | Becton, Dickinson And Company | Flow cytometric, whole blood dendritic cell immune function assay |
| US6495333B1 (en) | 1998-09-22 | 2002-12-17 | Becton Dickinson And Company | Flow cytometric, whole blood dendritic cell immune function assay |
| US6387888B1 (en) | 1998-09-30 | 2002-05-14 | American Foundation For Biological Research, Inc. | Immunotherapy of cancer through expression of truncated tumor or tumor-associated antigen |
| US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
| DE69942100D1 (de) | 1998-10-20 | 2010-04-15 | Androclus Technologies S R L I | Künstliche antigen-spezifischen zellen und zugehörige verfahren |
| US6787154B2 (en) * | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
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| CA2760534A1 (en) | 1999-04-14 | 2000-10-19 | Novartis Vaccines And Diagnostics, Inc. | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
| US7713739B1 (en) | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| US7015205B1 (en) | 1999-10-18 | 2006-03-21 | St. Vincent's Hospital And Medical Center Of New York | Melanoma vaccine and methods of making and using same |
| KR100363587B1 (ko) * | 1999-11-12 | 2002-12-06 | 이시우 | 대식세포와 종양세포의 융합에 의한 항종양 세포성 치료제 |
| AU785198B2 (en) * | 1999-11-15 | 2006-11-02 | Miltenyi Biotec B.V. & Co. KG | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognised thereby and cells obtained thereby |
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| JP2021533759A (ja) * | 2018-08-10 | 2021-12-09 | ユーティレックス カンパニー リミテッド | 癌抗原特異的cd8+t細胞を調製および凍結保存するための方法 |
Family Cites Families (11)
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|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) * | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| US5162504A (en) * | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
| US20030072751A1 (en) * | 1990-03-14 | 2003-04-17 | Heribert Bohlen | Idiotypic vaccination against b cell lymphoma |
| US5227471A (en) * | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
| AU4678993A (en) * | 1992-07-16 | 1994-02-14 | Board Of Trustees Of The Leland Stanford Junior University | Methods for using dendritic cells to activate t cells |
| EP0692973A1 (en) * | 1993-03-15 | 1996-01-24 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Peptide coated dendritic cells as immunogens |
| CA2192655A1 (en) * | 1994-06-14 | 1995-12-21 | Edgar G. Engleman | Methods for in vivo t cell activation by antigen-pulsed dendritic cells |
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1995
- 1995-07-31 US US08/509,254 patent/US5788963A/en not_active Expired - Lifetime
-
1996
- 1996-07-29 CA CA2228176A patent/CA2228176C/en not_active Expired - Lifetime
- 1996-07-29 EP EP10183831A patent/EP2377548A3/en not_active Withdrawn
- 1996-07-29 DE DE0841940T patent/DE841940T1/de active Pending
- 1996-07-29 EP EP96927268A patent/EP0841940A4/en not_active Withdrawn
- 1996-07-29 AU AU67146/96A patent/AU723607B2/en not_active Expired
- 1996-07-29 NZ NZ315441A patent/NZ315441A/xx unknown
- 1996-07-29 WO PCT/US1996/012389 patent/WO1997004802A1/en not_active Ceased
- 1996-07-29 IL IL12307996A patent/IL123079A0/xx not_active IP Right Cessation
- 1996-07-29 JP JP50782397A patent/JP4267692B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-14 US US13/523,828 patent/US20130017600A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2228176C (en) | 2015-05-26 |
| JP2001520633A (ja) | 2001-10-30 |
| EP2377548A2 (en) | 2011-10-19 |
| CA2228176A1 (en) | 1997-02-13 |
| US5788963A (en) | 1998-08-04 |
| AU6714696A (en) | 1997-02-26 |
| JP4267692B2 (ja) | 2009-05-27 |
| EP2377548A3 (en) | 2012-10-10 |
| MX9800821A (es) | 1998-10-31 |
| NZ315441A (en) | 1999-06-29 |
| AU723607B2 (en) | 2000-08-31 |
| US20130017600A1 (en) | 2013-01-17 |
| WO1997004802A1 (en) | 1997-02-13 |
| IL123079A0 (en) | 1998-09-24 |
| EP0841940A1 (en) | 1998-05-20 |
| EP0841940A4 (en) | 2005-01-05 |
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