DE69931140D1 - Hemmung der angiogenese durch peptidanaloge der kininogen domäne 5mit hohem molekulargewicht - Google Patents

Hemmung der angiogenese durch peptidanaloge der kininogen domäne 5mit hohem molekulargewicht

Info

Publication number
DE69931140D1
DE69931140D1 DE69931140T DE69931140T DE69931140D1 DE 69931140 D1 DE69931140 D1 DE 69931140D1 DE 69931140 T DE69931140 T DE 69931140T DE 69931140 T DE69931140 T DE 69931140T DE 69931140 D1 DE69931140 D1 DE 69931140D1
Authority
DE
Germany
Prior art keywords
angiogenesis
molecular weight
high molecular
inhibition
peptide analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69931140T
Other languages
English (en)
Other versions
DE69931140T2 (de
Inventor
Robert Colman
Shaker Mousa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Temple University of Commonwealth System of Higher Education
Original Assignee
Temple University of Commonwealth System of Higher Education
DuPont Merck Pharmaceutical Co
DuPont Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University of Commonwealth System of Higher Education, DuPont Merck Pharmaceutical Co, DuPont Pharmaceuticals Co filed Critical Temple University of Commonwealth System of Higher Education
Application granted granted Critical
Publication of DE69931140D1 publication Critical patent/DE69931140D1/de
Publication of DE69931140T2 publication Critical patent/DE69931140T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69931140T 1998-11-10 1999-11-09 Hemmung der angiogenese durch peptidanaloge der kininogen domäne 5mit hohem molekulargewicht Expired - Lifetime DE69931140T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10784498P 1998-11-10 1998-11-10
US107844P 1998-11-10
PCT/US1999/026377 WO2000027415A2 (en) 1998-11-10 1999-11-09 Inhibition of angiogenesis by peptide analogs of high molecular weight kininogen domain 5

Publications (2)

Publication Number Publication Date
DE69931140D1 true DE69931140D1 (de) 2006-06-08
DE69931140T2 DE69931140T2 (de) 2007-02-01

Family

ID=22318781

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69931140T Expired - Lifetime DE69931140T2 (de) 1998-11-10 1999-11-09 Hemmung der angiogenese durch peptidanaloge der kininogen domäne 5mit hohem molekulargewicht

Country Status (6)

Country Link
US (1) US6284726B1 (de)
EP (1) EP1044012B1 (de)
AT (1) ATE324901T1 (de)
AU (1) AU1521500A (de)
DE (1) DE69931140T2 (de)
WO (1) WO2000027415A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767889B1 (en) * 1998-11-10 2004-07-27 Temple University Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof
US6821947B2 (en) * 2001-12-04 2004-11-23 Thomas Jefferson University Endorepellin: methods and compositions for inhibiting angiogenesis
EP1344531A1 (de) * 2002-03-15 2003-09-17 Aventis Behring GmbH Peptide abgeleitet von der Domäne 5 von Kininogen von hohem Molekulargewicht (HK) gegen thrombische Krankheiten
US7098187B2 (en) * 2002-09-13 2006-08-29 Attenuon, Llc Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent
SE0301431D0 (sv) * 2003-05-19 2003-05-19 Dermagen Novel antimicrobial peptides
US8440217B1 (en) 2005-06-15 2013-05-14 Mawaheb M. EL-Naggar Method and system with contact lens product for treating and preventing adverse eye conditions
US8883153B2 (en) * 2009-03-27 2014-11-11 The Research for The State University of New York Methods for preventing and treating angioedema
EP3390439A1 (de) 2015-12-15 2018-10-24 Dyax Corp. Peptidquantifizierungstest zur differenzierung von hochmolekularem kininogen voller länge (hmwk) und gespaltenem hmwk
EP3562499A1 (de) * 2016-12-29 2019-11-06 Development Center for Biotechnology Aus kininogen-1 abgeleitete peptide für proteinarzneimittel in vivo

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
US5596079A (en) 1991-12-16 1997-01-21 Smith; James R. Mimetics of senescent cell derived inhibitors of DNA synthesis
US5756291A (en) 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
JPH0782172A (ja) * 1993-09-17 1995-03-28 Hoechst Japan Ltd 創傷治療剤
EP0758452B1 (de) 1994-05-04 2001-11-07 Mount Sinai Hospital Corporation Modulatoren der cytokine der tgf-beta überfamilie und verfahren zu ihrer bestimmung
JPH08208692A (ja) 1994-09-28 1996-08-13 Sumitomo Pharmaceut Co Ltd 新規な細胞接着抑制ペプチド誘導体
EP2301562B1 (de) * 1994-12-12 2013-04-17 Omeros Corporation Bespülungslösung und deren Verwendung zur perioperativen Hemmung von Schmerzen, Entzündungen und/oder Spasmen
US5817748A (en) 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX
AU703256B2 (en) 1995-06-09 1999-03-25 Regents Of The University Of Michigan, The Bradykinin analogs as selective thrombin inhibitors
EP0808627A2 (de) 1996-05-22 1997-11-26 Hoechst Aktiengesellschaft Verwendung nicht-peptidischer Bradykinin-Antagonisten zur Behandlung und Prävention von chronisch-fibrogenetischen Lebererkrankungen, akuten Lebererkrankungen und den damit verbundenen Komplikationen
CA2187728A1 (en) 1996-05-29 1997-11-29 Mary Lou Guerinot Iron-regulated metal transporters and uses therefor

Also Published As

Publication number Publication date
US6284726B1 (en) 2001-09-04
EP1044012A4 (de) 2003-07-09
EP1044012A1 (de) 2000-10-18
AU1521500A (en) 2000-05-29
EP1044012B1 (de) 2006-05-03
WO2000027415A2 (en) 2000-05-18
DE69931140T2 (de) 2007-02-01
ATE324901T1 (de) 2006-06-15

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HI

Owner name: BRISTOL-MYERS SQUIBB PHARMA CO., PRINCETON, N.J.,

Owner name: COLMAN, W. ROBERT, MOYLAND, PA., US

Owner name: MOUSA, A. SHAKER, NEW LONDON, PA., US

8327 Change in the person/name/address of the patent owner

Owner name: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HI

Owner name: BRISTOL-MYERS SQUIBB PHARMA CO., PRINCETON, N.J.,

8328 Change in the person/name/address of the agent

Representative=s name: PATENTANWAELTE DR. STURIES EICHLER FUESSEL, 42289 WU

8364 No opposition during term of opposition