ATE528287T1 - Nicht peptidische rgd-analoga mit adhäsions-, migrations- und proliferationshemmender wirkung - Google Patents
Nicht peptidische rgd-analoga mit adhäsions-, migrations- und proliferationshemmender wirkungInfo
- Publication number
- ATE528287T1 ATE528287T1 AT02708622T AT02708622T ATE528287T1 AT E528287 T1 ATE528287 T1 AT E528287T1 AT 02708622 T AT02708622 T AT 02708622T AT 02708622 T AT02708622 T AT 02708622T AT E528287 T1 ATE528287 T1 AT E528287T1
- Authority
- AT
- Austria
- Prior art keywords
- adhesion
- migration
- proliferation effects
- peptidic
- proliferation
- Prior art date
Links
- 230000005012 migration Effects 0.000 title abstract 2
- 238000013508 migration Methods 0.000 title abstract 2
- 230000035755 proliferation Effects 0.000 title abstract 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000089A ITRM20010089A1 (it) | 2001-02-21 | 2001-02-21 | Molecole non peptidiche analoghe al peptide rgd con effetto inibitorio sulla adesione, la migrazione e la proliferazione cellulare. |
| PCT/IT2002/000099 WO2002066421A1 (en) | 2001-02-21 | 2002-02-19 | Rgd-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE528287T1 true ATE528287T1 (de) | 2011-10-15 |
Family
ID=11455245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02708622T ATE528287T1 (de) | 2001-02-21 | 2002-02-19 | Nicht peptidische rgd-analoga mit adhäsions-, migrations- und proliferationshemmender wirkung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6627769B2 (de) |
| EP (1) | EP1366022B1 (de) |
| JP (1) | JP2004527488A (de) |
| AT (1) | ATE528287T1 (de) |
| AU (1) | AU2002242948B2 (de) |
| IT (1) | ITRM20010089A1 (de) |
| WO (1) | WO2002066421A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004094457A2 (en) * | 2003-04-16 | 2004-11-04 | Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University | Stable rgd peptidomimetic composition |
| US20060029544A1 (en) * | 2004-08-06 | 2006-02-09 | The Regents Of The University Of California Office Of Technology Transfer | Receptor-binding cyclic peptides and methods of use |
| WO2017040037A1 (en) | 2015-08-31 | 2017-03-09 | Dow Global Technologies Llc | Methods of preparing vinylidene chloride polymer compositions |
| WO2017040036A1 (en) | 2015-08-31 | 2017-03-09 | Dow Global Technologies Llc | Vinylidene chloride polymer compositions and articles comprising the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992013552A1 (en) | 1991-02-05 | 1992-08-20 | Smithkline Beecham Corporation | Anti-aggregatory peptides containing an aromatic ester or amide |
| US5352667A (en) | 1991-11-22 | 1994-10-04 | Ofer Lider | Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmaceutical compositions comprising them |
| JP3274225B2 (ja) | 1992-06-03 | 2002-04-15 | 富士写真フイルム株式会社 | アミノ酸誘導体及びその用途 |
| US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
-
2001
- 2001-02-21 IT IT2001RM000089A patent/ITRM20010089A1/it unknown
-
2002
- 2002-02-19 JP JP2002565939A patent/JP2004527488A/ja active Pending
- 2002-02-19 AU AU2002242948A patent/AU2002242948B2/en not_active Ceased
- 2002-02-19 WO PCT/IT2002/000099 patent/WO2002066421A1/en not_active Ceased
- 2002-02-19 EP EP02708622A patent/EP1366022B1/de not_active Expired - Lifetime
- 2002-02-19 AT AT02708622T patent/ATE528287T1/de not_active IP Right Cessation
- 2002-02-20 US US10/077,948 patent/US6627769B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1366022B1 (de) | 2011-10-12 |
| JP2004527488A (ja) | 2004-09-09 |
| WO2002066421A1 (en) | 2002-08-29 |
| AU2002242948B2 (en) | 2007-12-20 |
| ITRM20010089A1 (it) | 2002-08-21 |
| ITRM20010089A0 (it) | 2001-02-21 |
| US20020119932A1 (en) | 2002-08-29 |
| EP1366022A1 (de) | 2003-12-03 |
| US6627769B2 (en) | 2003-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |