ATE528287T1 - Nicht peptidische rgd-analoga mit adhäsions-, migrations- und proliferationshemmender wirkung - Google Patents

Nicht peptidische rgd-analoga mit adhäsions-, migrations- und proliferationshemmender wirkung

Info

Publication number
ATE528287T1
ATE528287T1 AT02708622T AT02708622T ATE528287T1 AT E528287 T1 ATE528287 T1 AT E528287T1 AT 02708622 T AT02708622 T AT 02708622T AT 02708622 T AT02708622 T AT 02708622T AT E528287 T1 ATE528287 T1 AT E528287T1
Authority
AT
Austria
Prior art keywords
adhesion
migration
proliferation effects
peptidic
proliferation
Prior art date
Application number
AT02708622T
Other languages
English (en)
Inventor
Antonio Facchiano
Francesco Facchiano
Ivan Rossi
Rita Casadio
Original Assignee
Provincia Italiana Della Congregazione Dei Figli Dell Immacolata Concezione Istituto Dermopatico Del
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provincia Italiana Della Congregazione Dei Figli Dell Immacolata Concezione Istituto Dermopatico Del filed Critical Provincia Italiana Della Congregazione Dei Figli Dell Immacolata Concezione Istituto Dermopatico Del
Application granted granted Critical
Publication of ATE528287T1 publication Critical patent/ATE528287T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02708622T 2001-02-21 2002-02-19 Nicht peptidische rgd-analoga mit adhäsions-, migrations- und proliferationshemmender wirkung ATE528287T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001RM000089A ITRM20010089A1 (it) 2001-02-21 2001-02-21 Molecole non peptidiche analoghe al peptide rgd con effetto inibitorio sulla adesione, la migrazione e la proliferazione cellulare.
PCT/IT2002/000099 WO2002066421A1 (en) 2001-02-21 2002-02-19 Rgd-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects

Publications (1)

Publication Number Publication Date
ATE528287T1 true ATE528287T1 (de) 2011-10-15

Family

ID=11455245

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02708622T ATE528287T1 (de) 2001-02-21 2002-02-19 Nicht peptidische rgd-analoga mit adhäsions-, migrations- und proliferationshemmender wirkung

Country Status (7)

Country Link
US (1) US6627769B2 (de)
EP (1) EP1366022B1 (de)
JP (1) JP2004527488A (de)
AT (1) ATE528287T1 (de)
AU (1) AU2002242948B2 (de)
IT (1) ITRM20010089A1 (de)
WO (1) WO2002066421A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060246104A1 (en) * 2003-04-16 2006-11-02 Massia Stephen P Stable rgd peptidomimetic composition
WO2006017619A2 (en) * 2004-08-06 2006-02-16 The Regents Of The University Of California Receptor-binding cyclic peptides and methods of use
WO2017040037A1 (en) 2015-08-31 2017-03-09 Dow Global Technologies Llc Methods of preparing vinylidene chloride polymer compositions
BR112018002495A2 (pt) 2015-08-31 2018-09-18 Dow Global Technologies Llc composições de polímero de cloreto de vinidileno e artigos compreendendo as mesmas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0570507A4 (en) 1991-02-05 1994-09-21 Smithkline Beecham Corp Anti-aggregatory peptides containing an aromatic ester or amide
JPH07503944A (ja) 1991-11-22 1995-04-27 イエダ　リサーチ　アンド　デベロツプメント　カンパニー　リミテツド Ａｒｇ−ｇｌｙ−ａｓｐ配列の非ペプチド代替物およびそれらからなる医薬組成物
JP3274225B2 (ja) 1992-06-03 2002-04-15 富士写真フイルム株式会社 アミノ酸誘導体及びその用途
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions

Also Published As

Publication number Publication date
US6627769B2 (en) 2003-09-30
EP1366022A1 (de) 2003-12-03
US20020119932A1 (en) 2002-08-29
EP1366022B1 (de) 2011-10-12
AU2002242948B2 (en) 2007-12-20
WO2002066421A1 (en) 2002-08-29
JP2004527488A (ja) 2004-09-09
ITRM20010089A0 (it) 2001-02-21
ITRM20010089A1 (it) 2002-08-21

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties