DE69927400T2 - Pge synthase und verfahren und mitteln zur modulation deren aktivität - Google Patents
Pge synthase und verfahren und mitteln zur modulation deren aktivität Download PDFInfo
- Publication number
- DE69927400T2 DE69927400T2 DE69927400T DE69927400T DE69927400T2 DE 69927400 T2 DE69927400 T2 DE 69927400T2 DE 69927400 T DE69927400 T DE 69927400T DE 69927400 T DE69927400 T DE 69927400T DE 69927400 T2 DE69927400 T2 DE 69927400T2
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- polypeptide
- pge
- pge synthase
- seq
- amino acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10768798P | 1998-11-09 | 1998-11-09 | |
| US107687P | 1998-11-09 | ||
| PCT/EP1999/008363 WO2000028022A1 (en) | 1998-11-09 | 1999-11-02 | Pge synthase and methods and means for modulating its activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69927400D1 DE69927400D1 (de) | 2006-02-02 |
| DE69927400T2 true DE69927400T2 (de) | 2006-06-29 |
Family
ID=22317930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69927400T Expired - Lifetime DE69927400T2 (de) | 1998-11-09 | 1999-11-02 | Pge synthase und verfahren und mitteln zur modulation deren aktivität |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6395502B1 (enExample) |
| EP (1) | EP1129188B1 (enExample) |
| JP (2) | JP4503849B2 (enExample) |
| AT (1) | ATE305040T1 (enExample) |
| AU (1) | AU770307B2 (enExample) |
| CA (1) | CA2349529C (enExample) |
| DE (1) | DE69927400T2 (enExample) |
| ES (1) | ES2249042T3 (enExample) |
| WO (1) | WO2000028022A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2249042T3 (es) * | 1998-11-09 | 2006-03-16 | Karolinska Innovations Ab | Pge sintasa y procedimientos y medios para la modulacion de su actividad. |
| US7169580B1 (en) | 2000-02-03 | 2007-01-30 | Chugai Seiyaku Kabushiki Kaisha | Protein having PGE2 synthase activity and use thereof |
| JP2005526483A (ja) * | 2001-08-24 | 2005-09-08 | ファイザー・プロダクツ・インク | 精製されたプロスタグランジンｅシンターゼを調製するための方法 |
| CN1592576A (zh) * | 2001-11-30 | 2005-03-09 | 辉瑞产品公司 | 前列腺素e合酶2基因的破环 |
| JP2006500066A (ja) * | 2002-09-25 | 2006-01-05 | ファルマシア・コーポレーション | ミクロソームのプロスタグランジンｅ２シンターゼ発現のアンチセンス調節 |
| JP2006515763A (ja) * | 2003-01-27 | 2006-06-08 | ファイザー・プロダクツ・インク | プロスタグランジン・エンドペルオキシドｈ２を用いる又は生成する酵素の活性の測定にかかわる新規な方法 |
| WO2005024059A2 (en) * | 2003-09-09 | 2005-03-17 | Karolinska Innovations Ab | Methods for identifying compounds for inhibiting fever |
| US7638331B2 (en) | 2004-01-02 | 2009-12-29 | The Administration of the Tulane Rducation Fund | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
| US20090088400A1 (en) * | 2007-09-11 | 2009-04-02 | Puymirat Jack | Prostaglandin e2 modulation and uses thereof |
| CN117323320B (zh) * | 2023-11-20 | 2025-10-31 | 复旦大学附属中山医院 | 长链脂肪酸12-hht在睡眠呼吸暂停合并高血压中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US914356A (en) * | 1901-11-30 | 1909-03-02 | Harry Ward Leonard | Electric-circuit controller. |
| EP1015624A2 (en) * | 1997-09-17 | 2000-07-05 | The Johns Hopkins University | P53-induced apoptosis |
| ES2249042T3 (es) * | 1998-11-09 | 2006-03-16 | Karolinska Innovations Ab | Pge sintasa y procedimientos y medios para la modulacion de su actividad. |
-
1999
- 1999-11-02 ES ES99957275T patent/ES2249042T3/es not_active Expired - Lifetime
- 1999-11-02 AT AT99957275T patent/ATE305040T1/de not_active IP Right Cessation
- 1999-11-02 WO PCT/EP1999/008363 patent/WO2000028022A1/en not_active Ceased
- 1999-11-02 DE DE69927400T patent/DE69927400T2/de not_active Expired - Lifetime
- 1999-11-02 AU AU15041/00A patent/AU770307B2/en not_active Expired
- 1999-11-02 CA CA002349529A patent/CA2349529C/en not_active Expired - Lifetime
- 1999-11-02 EP EP99957275A patent/EP1129188B1/en not_active Expired - Lifetime
- 1999-11-02 JP JP2000581189A patent/JP4503849B2/ja not_active Expired - Lifetime
- 1999-11-04 US US09/433,466 patent/US6395502B1/en not_active Expired - Lifetime
-
2002
- 2002-03-28 US US10/109,438 patent/US7067296B2/en not_active Expired - Lifetime
-
2004
- 2004-10-07 US US10/962,155 patent/US7192733B2/en not_active Expired - Lifetime
-
2007
- 2007-02-27 US US11/679,585 patent/US7645601B2/en not_active Expired - Lifetime
-
2010
- 2010-01-21 JP JP2010011053A patent/JP2010115205A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7067296B2 (en) | 2006-06-27 |
| JP2002539762A (ja) | 2002-11-26 |
| AU770307B2 (en) | 2004-02-19 |
| US7192733B2 (en) | 2007-03-20 |
| US7645601B2 (en) | 2010-01-12 |
| ATE305040T1 (de) | 2005-10-15 |
| CA2349529A1 (en) | 2000-05-18 |
| EP1129188B1 (en) | 2005-09-21 |
| JP2010115205A (ja) | 2010-05-27 |
| WO2000028022A1 (en) | 2000-05-18 |
| EP1129188A1 (en) | 2001-09-05 |
| US20030064493A1 (en) | 2003-04-03 |
| JP4503849B2 (ja) | 2010-07-14 |
| US20050118696A1 (en) | 2005-06-02 |
| US20080153107A1 (en) | 2008-06-26 |
| DE69927400D1 (de) | 2006-02-02 |
| ES2249042T3 (es) | 2006-03-16 |
| CA2349529C (en) | 2009-10-27 |
| AU1504100A (en) | 2000-05-29 |
| US6395502B1 (en) | 2002-05-28 |
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