DE69924973T2 - Eingekapselte brachytherapie quellen mit niedriger energie - Google Patents
Eingekapselte brachytherapie quellen mit niedriger energie Download PDFInfo
- Publication number
- DE69924973T2 DE69924973T2 DE69924973T DE69924973T DE69924973T2 DE 69924973 T2 DE69924973 T2 DE 69924973T2 DE 69924973 T DE69924973 T DE 69924973T DE 69924973 T DE69924973 T DE 69924973T DE 69924973 T2 DE69924973 T2 DE 69924973T2
- Authority
- DE
- Germany
- Prior art keywords
- source according
- source
- substrate
- annulus
- plug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002725 brachytherapy Methods 0.000 title claims description 23
- 239000002775 capsule Substances 0.000 claims description 35
- 239000000758 substrate Substances 0.000 claims description 28
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 19
- 239000010457 zeolite Substances 0.000 claims description 19
- 229910021536 Zeolite Inorganic materials 0.000 claims description 18
- 229910052751 metal Inorganic materials 0.000 claims description 16
- 239000002184 metal Substances 0.000 claims description 16
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 12
- KDLHZDBZIXYQEI-OIOBTWANSA-N palladium-103 Chemical group [103Pd] KDLHZDBZIXYQEI-OIOBTWANSA-N 0.000 claims description 12
- 239000010936 titanium Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 10
- 229910052719 titanium Inorganic materials 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 9
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 claims description 9
- 238000003466 welding Methods 0.000 claims description 8
- 229940044173 iodine-125 Drugs 0.000 claims description 7
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 claims description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 229910001385 heavy metal Inorganic materials 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- 229910045601 alloy Inorganic materials 0.000 claims description 2
- 239000000956 alloy Substances 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 229910052709 silver Inorganic materials 0.000 claims description 2
- 239000004332 silver Substances 0.000 claims description 2
- 229910052715 tantalum Inorganic materials 0.000 claims description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 2
- 229910052721 tungsten Inorganic materials 0.000 claims description 2
- 239000010937 tungsten Substances 0.000 claims description 2
- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical group [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 description 25
- 230000005855 radiation Effects 0.000 description 22
- 230000002285 radioactive effect Effects 0.000 description 15
- PNDPGZBMCMUPRI-XXSWNUTMSA-N [125I][125I] Chemical compound [125I][125I] PNDPGZBMCMUPRI-XXSWNUTMSA-N 0.000 description 6
- 239000007943 implant Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012857 radioactive material Substances 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 241001457926 Brachys Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- GKOZUEZYRPOHIO-IGMARMGPSA-N iridium-192 Chemical compound [192Ir] GKOZUEZYRPOHIO-IGMARMGPSA-N 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- TVFDJXOCXUVLDH-YPZZEJLDSA-N cesium-131 Chemical compound [131Cs] TVFDJXOCXUVLDH-YPZZEJLDSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000012938 design process Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- -1 platinum-iridium alloy metals Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229910052705 radium Inorganic materials 0.000 description 1
- HCWPIIXVSYCSAN-UHFFFAOYSA-N radium atom Chemical compound [Ra] HCWPIIXVSYCSAN-UHFFFAOYSA-N 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- KZUNJOHGWZRPMI-FTXFMUIASA-N samarium-145 Chemical compound [145Sm] KZUNJOHGWZRPMI-FTXFMUIASA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- GZCRRIHWUXGPOV-NJFSPNSNSA-N terbium-161 Chemical compound [161Tb] GZCRRIHWUXGPOV-NJFSPNSNSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- FRNOGLGSGLTDKL-OUBTZVSYSA-N thulium-170 Chemical compound [170Tm] FRNOGLGSGLTDKL-OUBTZVSYSA-N 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1024—Seeds
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7455098P | 1998-02-12 | 1998-02-12 | |
| US74550P | 1998-02-12 | ||
| PCT/CA1999/000112 WO1999040970A1 (en) | 1998-02-12 | 1999-02-09 | Encapsulated low-energy brachytherapy sources |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69924973D1 DE69924973D1 (de) | 2005-06-02 |
| DE69924973T2 true DE69924973T2 (de) | 2006-03-09 |
Family
ID=22120163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69924973T Expired - Fee Related DE69924973T2 (de) | 1998-02-12 | 1999-02-09 | Eingekapselte brachytherapie quellen mit niedriger energie |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6099458A (enExample) |
| EP (1) | EP1054707B1 (enExample) |
| JP (1) | JP2002502676A (enExample) |
| CN (1) | CN1198668C (enExample) |
| AU (1) | AU745288B2 (enExample) |
| CA (1) | CA2261338A1 (enExample) |
| DE (1) | DE69924973T2 (enExample) |
| WO (1) | WO1999040970A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6503186B1 (en) | 1997-08-01 | 2003-01-07 | North American Scientific, Inc. | Radioactive seed with multiple markers and method for using same |
| HUP0004411A3 (en) * | 1997-11-14 | 2001-06-28 | Pont Pharmaceuticals Company W | Process for the selective oxidation of organic compounds and for the preparing of the moleculesieve catalysts |
| US6080099A (en) * | 1998-08-12 | 2000-06-27 | Syntheon, Llc | Radioactive therapeutic seeds |
| DE19850203C1 (de) * | 1998-10-23 | 2000-05-31 | Eurotope Entwicklungsgesellsch | Radioaktive Jod-125-Seeds basierend auf Keramikträgern und Verfahren zur Herstellung dieser Seeds |
| CN1206079C (zh) * | 1998-11-20 | 2005-06-15 | 阿默森保健公司 | 焊接方法 |
| US6482143B1 (en) * | 1999-02-28 | 2002-11-19 | Syntheon, Llc | Raidoactive therapeutic seed having selective marker configuration |
| US6575888B2 (en) | 2000-01-25 | 2003-06-10 | Biosurface Engineering Technologies, Inc. | Bioabsorbable brachytherapy device |
| JP2006500115A (ja) | 2000-11-16 | 2006-01-05 | マイクロスフエリツクス・エル・エル・シー | 密封小線源治療用の可撓性および／または弾性シードまたはストランド |
| US6746661B2 (en) * | 2000-11-16 | 2004-06-08 | Microspherix Llc | Brachytherapy seed |
| US6527693B2 (en) * | 2001-01-30 | 2003-03-04 | Implant Sciences Corporation | Methods and implants for providing radiation to a patient |
| US20020169354A1 (en) | 2001-05-10 | 2002-11-14 | Munro John J. | Brachytherapy systems and methods |
| US6471632B1 (en) | 2001-05-18 | 2002-10-29 | Syntheon, Llc | Radioactive therapeutic seeds |
| US6723052B2 (en) | 2001-06-07 | 2004-04-20 | Stanley L. Mills | Echogenic medical device |
| JP4166691B2 (ja) * | 2001-08-03 | 2008-10-15 | タイコ ヘルスケア グループ エルピー | 組織マーキング装置および方法 |
| IL147898A (en) * | 2002-01-30 | 2007-05-15 | Yuval Golan | A method of treating cancer based on the Ugar effect |
| US7410458B2 (en) * | 2003-11-12 | 2008-08-12 | Isoray Medical, Inc. | Brachytherapy implant seeds |
| CA2571349C (en) * | 2004-06-28 | 2014-04-22 | Isoray Medical, Inc. | Method of separating and purifying cesium-131 from barium nitrate |
| US7517508B2 (en) * | 2004-07-26 | 2009-04-14 | Isoray Medical, Inc. | Method of separating and purifying Yttrium-90 from Strontium-90 |
| WO2006038958A1 (en) * | 2004-07-28 | 2006-04-13 | Isoray Medical, Inc. | Method of separating and purifying cesium-131 from barium carbonate |
| EA200700216A1 (ru) * | 2004-08-18 | 2007-08-31 | Айсорей Медикал, Инк. | Способ получения частиц радиоактивного порошка, содержащего цезий-131, для использования в источниках для брахитерапии |
| US7350479B2 (en) * | 2004-09-10 | 2008-04-01 | United States Of America As Represented By The Secretary Of The Army | System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp |
| US8187159B2 (en) | 2005-07-22 | 2012-05-29 | Biocompatibles, UK | Therapeutic member including a rail used in brachytherapy and other radiation therapy |
| US7736293B2 (en) | 2005-07-22 | 2010-06-15 | Biocompatibles Uk Limited | Implants for use in brachytherapy and other radiation therapy that resist migration and rotation |
| US7510691B2 (en) * | 2006-02-28 | 2009-03-31 | Isoray Medical, Inc. | Method for improving the recovery of cesium-131 from barium carbonate |
| WO2008041230A1 (en) * | 2006-10-02 | 2008-04-10 | Ben-Gurion University Of The Negev Research And Development Authority | Thulium-based capsule and devices for use in high dose rate brachytherapy |
| WO2008111065A1 (en) * | 2007-03-12 | 2008-09-18 | Ben-Gurion University Of The Negev Research And Development Authority | Thulium-containing low dose rate brachytherapy seed |
| US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
| EP3143627B1 (en) * | 2014-05-13 | 2018-07-11 | QSA Global Inc. | Device and method for enhanced iridium gamma radiation sources |
| EP3329495B1 (en) * | 2015-07-28 | 2019-11-20 | Illinois Tool Works Inc. | Source wire assembly for radiographic applications |
| RU2719322C1 (ru) * | 2016-05-24 | 2020-04-17 | КьюЭсЭй ГЛОБАЛ ИНК. | Сферический иридиевый источник низкой плотности |
| WO2018207105A1 (en) | 2017-05-11 | 2018-11-15 | Alpha Tau Medical Ltd. | Polymer coatings for brachytherapy devices |
| KR102715288B1 (ko) | 2018-04-02 | 2024-10-11 | 알파 타우 메디컬 리미티드 | 방사성 핵종의 제어된 방출 |
| WO2019246073A1 (en) * | 2018-06-19 | 2019-12-26 | Qsa Global Inc. | Low density iridium source |
| US12285627B2 (en) | 2018-10-19 | 2025-04-29 | Colorado School Of Mines | Fabrication and irradiation of a radioactive isotope skin patch |
| US11504546B2 (en) | 2019-02-28 | 2022-11-22 | Cowles Ventures, Llc | Needle guidance device for brachytherapy and method of use |
| US11524176B2 (en) | 2019-03-14 | 2022-12-13 | Cowles Ventures, Llc | Locator for placement of fiducial support device method |
| EP4262888A4 (en) | 2020-12-16 | 2024-10-30 | Alpha Tau Medical Ltd. | DIFFUSION ALPHA-EMITTER RADIATION THERAPY WITH IMPROVED BETA TREATMENT |
| US12076583B2 (en) | 2021-06-10 | 2024-09-03 | Alpha Tau Medical Ltd. | Diffusing alpha-emitter radiation therapy for melanoma |
| US12070620B2 (en) | 2021-06-10 | 2024-08-27 | Alpha Tau Medical Ltd. | Activity levels for diffusing alpha-emitter radiation therapy |
| US12064643B2 (en) | 2021-06-10 | 2024-08-20 | Alpha Tau Medical Ltd. | Diffusing alpha-emitter radiation therapy for breast cancer |
| US12076581B2 (en) | 2021-06-10 | 2024-09-03 | Alpha Tau Medical Ltd. | Diffusing alpha-emitter radiation therapy for glioblastoma |
| US12076582B2 (en) | 2021-06-10 | 2024-09-03 | Alpha Tau Medical Ltd. | Diffusing alpha-emitter radiation therapy for colorectal cancer |
| US12070621B2 (en) | 2021-06-10 | 2024-08-27 | Alpha Tau Medical Ltd. | Diffusing alpha-emitter radiation therapy for pancreatic cancer |
| US12042668B2 (en) | 2021-06-10 | 2024-07-23 | Alpha Tau Medical Ltd. | Diffusing alpha-emitter radiation therapy for squamous cell carcinoma |
| US11964168B2 (en) | 2021-06-10 | 2024-04-23 | Alpha Tau Medical Ltd. | Diffusing alpha-emitter radiation therapy for prostate cancer |
| DE102023125069B3 (de) * | 2023-09-15 | 2025-02-13 | Framatome | Bestrahlungseinheit zur Emission einer Kernstrahlung und entsprechendes Verfahren zur Herstellung einer Bestrahlungseinheit |
| WO2025245220A1 (en) * | 2024-05-22 | 2025-11-27 | Fusion Energy Solutions, Inc. | Welding machine |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1753287A (en) | 1925-05-15 | 1930-04-08 | Failla Gioacchino | Method and means for applying radium emanation |
| US3351049A (en) | 1965-04-12 | 1967-11-07 | Hazleton Nuclear Science Corp | Therapeutic metal seed containing within a radioactive isotope disposed on a carrier and method of manufacture |
| US4323055A (en) | 1980-04-08 | 1982-04-06 | Minnesota Mining And Manufacturing Company | Radioactive iodine seed |
| US4702228A (en) | 1985-01-24 | 1987-10-27 | Theragenics Corporation | X-ray-emitting interstitial implants |
| US4994013A (en) | 1988-07-28 | 1991-02-19 | Best Industries, Inc. | Pellet for a radioactive seed |
| US4891165A (en) | 1988-07-28 | 1990-01-02 | Best Industries, Inc. | Device and method for encapsulating radioactive materials |
| US5342283A (en) | 1990-08-13 | 1994-08-30 | Good Roger R | Endocurietherapy |
| US5405309A (en) | 1993-04-28 | 1995-04-11 | Theragenics Corporation | X-ray emitting interstitial implants |
| US6007475A (en) * | 1998-08-12 | 1999-12-28 | Cns Technology, Inc. | Radioactive therapeutic seeds |
-
1999
- 1999-02-09 CA CA002261338A patent/CA2261338A1/en not_active Abandoned
- 1999-02-09 CN CNB998049743A patent/CN1198668C/zh not_active Expired - Fee Related
- 1999-02-09 DE DE69924973T patent/DE69924973T2/de not_active Expired - Fee Related
- 1999-02-09 EP EP99904644A patent/EP1054707B1/en not_active Expired - Lifetime
- 1999-02-09 WO PCT/CA1999/000112 patent/WO1999040970A1/en not_active Ceased
- 1999-02-09 JP JP2000531221A patent/JP2002502676A/ja active Pending
- 1999-02-09 AU AU25058/99A patent/AU745288B2/en not_active Ceased
- 1999-02-11 US US09/248,099 patent/US6099458A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU745288B2 (en) | 2002-03-21 |
| EP1054707B1 (en) | 2005-04-27 |
| CA2261338A1 (en) | 1999-08-12 |
| US6099458A (en) | 2000-08-08 |
| CN1329512A (zh) | 2002-01-02 |
| DE69924973D1 (de) | 2005-06-02 |
| EP1054707A1 (en) | 2000-11-29 |
| CN1198668C (zh) | 2005-04-27 |
| AU2505899A (en) | 1999-08-30 |
| WO1999040970A1 (en) | 1999-08-19 |
| JP2002502676A (ja) | 2002-01-29 |
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