DE69923840D1 - Transfer von mRNAs unter Verwendung von polykationischen Verbindungen - Google Patents

Transfer von mRNAs unter Verwendung von polykationischen Verbindungen

Info

Publication number
DE69923840D1
DE69923840D1 DE69923840T DE69923840T DE69923840D1 DE 69923840 D1 DE69923840 D1 DE 69923840D1 DE 69923840 T DE69923840 T DE 69923840T DE 69923840 T DE69923840 T DE 69923840T DE 69923840 D1 DE69923840 D1 DE 69923840D1
Authority
DE
Germany
Prior art keywords
transfer
mrnas
rna
polycationic compounds
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69923840T
Other languages
English (en)
Other versions
DE69923840T2 (de
Inventor
Prof Dr Jung
Ingmar Hoerr
Prof Dr Rammensee
Dr Obst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curevac SE
Original Assignee
Curevac AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac AG filed Critical Curevac AG
Publication of DE69923840D1 publication Critical patent/DE69923840D1/de
Application granted granted Critical
Publication of DE69923840T2 publication Critical patent/DE69923840T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE69923840T 1999-09-09 1999-09-09 Transfer von mRNAs unter Verwendung von polykationischen Verbindungen Expired - Lifetime DE69923840T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99117771A EP1083232B1 (de) 1999-09-09 1999-09-09 Transfer von mRNAs unter Verwendung von polykationischen Verbindungen

Publications (2)

Publication Number Publication Date
DE69923840D1 true DE69923840D1 (de) 2005-03-31
DE69923840T2 DE69923840T2 (de) 2006-04-06

Family

ID=8238953

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69943068T Expired - Lifetime DE69943068D1 (de) 1999-09-09 1999-09-09 Transfer von mRNA unter Verwendung von polykationischen Verbindungen
DE69923840T Expired - Lifetime DE69923840T2 (de) 1999-09-09 1999-09-09 Transfer von mRNAs unter Verwendung von polykationischen Verbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69943068T Expired - Lifetime DE69943068D1 (de) 1999-09-09 1999-09-09 Transfer von mRNA unter Verwendung von polykationischen Verbindungen

Country Status (4)

Country Link
EP (4) EP1541690A3 (de)
AT (2) ATE289630T1 (de)
DE (2) DE69943068D1 (de)
ES (1) ES2238799T3 (de)

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Also Published As

Publication number Publication date
DE69943068D1 (de) 2011-02-03
EP1083232A1 (de) 2001-03-14
ATE289630T1 (de) 2005-03-15
EP1541690A2 (de) 2005-06-15
ES2238799T3 (es) 2005-09-01
EP1541690A3 (de) 2005-07-27
EP1083232B1 (de) 2005-02-23
EP1619254B1 (de) 2010-12-22
ATE492644T1 (de) 2011-01-15
DE69923840T2 (de) 2006-04-06
EP1818409A1 (de) 2007-08-15
EP1619254A1 (de) 2006-01-25

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