DE69917281T2 - Coumarin und damit verwandte aromatische polymere prodrugs - Google Patents
Coumarin und damit verwandte aromatische polymere prodrugs Download PDFInfo
- Publication number
- DE69917281T2 DE69917281T2 DE69917281T DE69917281T DE69917281T2 DE 69917281 T2 DE69917281 T2 DE 69917281T2 DE 69917281 T DE69917281 T DE 69917281T DE 69917281 T DE69917281 T DE 69917281T DE 69917281 T2 DE69917281 T2 DE 69917281T2
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- Germany
- Prior art keywords
- substituted
- group
- alkyl
- compound according
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 229920000642 polymer Polymers 0.000 title claims abstract description 56
- 239000000651 prodrug Substances 0.000 title claims abstract description 46
- 229940002612 prodrug Drugs 0.000 title claims abstract description 46
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title description 20
- 229960000956 coumarin Drugs 0.000 title description 10
- 235000001671 coumarin Nutrition 0.000 title description 10
- -1 C3-8 Chemical group 0.000 claims abstract description 45
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 39
- 150000001412 amines Chemical class 0.000 claims abstract description 26
- 125000003118 aryl group Chemical group 0.000 claims abstract description 26
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims abstract description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 24
- 239000001257 hydrogen Substances 0.000 claims abstract description 22
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- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 18
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 16
- 125000003107 substituted aryl group Chemical group 0.000 claims abstract description 14
- 125000002252 acyl group Chemical group 0.000 claims abstract description 12
- 125000004181 carboxyalkyl group Chemical group 0.000 claims abstract description 12
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract description 10
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- 125000000623 heterocyclic group Chemical class 0.000 claims abstract description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
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- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US114860 | 1998-07-13 | ||
| US09/114,860 US6214330B1 (en) | 1998-07-13 | 1998-07-13 | Coumarin and related aromatic-based polymeric prodrugs |
| PCT/US1999/015652 WO2000002568A1 (en) | 1998-07-13 | 1999-07-12 | Coumarin and related aromatic-based polymeric prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69917281D1 DE69917281D1 (de) | 2004-06-17 |
| DE69917281T2 true DE69917281T2 (de) | 2005-06-30 |
Family
ID=22357836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69917281T Expired - Lifetime DE69917281T2 (de) | 1998-07-13 | 1999-07-12 | Coumarin und damit verwandte aromatische polymere prodrugs |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6214330B1 (https=) |
| EP (1) | EP1102592B1 (https=) |
| JP (1) | JP4999226B2 (https=) |
| AT (1) | ATE266424T1 (https=) |
| AU (1) | AU4983999A (https=) |
| CA (1) | CA2336663C (https=) |
| DE (1) | DE69917281T2 (https=) |
| DK (1) | DK1102592T3 (https=) |
| WO (1) | WO2000002568A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004264958B2 (en) | 2003-08-13 | 2010-04-15 | Biocon, Ltd | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
| WO2005047245A2 (en) * | 2003-11-14 | 2005-05-26 | Wisconsin Alumni Research Foundation | Fluorescence assays with improved blocking groups |
| US20090214472A1 (en) * | 2004-03-01 | 2009-08-27 | Enzon Pharmaceuticals Inc. | Interferon-beta polymer conjugates |
| JP2007533750A (ja) * | 2004-04-21 | 2007-11-22 | アルザ コーポレイション | 緩和なチオール分解条件下で遊離可能なポリマー結合体 |
| WO2005105154A1 (en) * | 2004-04-21 | 2005-11-10 | Alza Corporation | Polymer conjugate releasable under mild thiolytic conditions |
| JP2010503708A (ja) * | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | 多官能性リンカーを含む標的化ポリマープロドラッグ |
| US8367065B2 (en) * | 2006-09-15 | 2013-02-05 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
| EP2176404A4 (en) * | 2007-07-11 | 2014-11-19 | Belrose Pharma Inc | POLYMERIC DRUG DELIVERY SYSTEMS WITH AN AROMATIC ALLYLIC ACID |
| RU2453332C2 (ru) | 2007-10-16 | 2012-06-20 | Байокон Лимитид | Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц |
| US20100036110A1 (en) * | 2008-08-08 | 2010-02-11 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US20100227327A1 (en) * | 2008-08-08 | 2010-09-09 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| NZ758049A (en) | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| KR20180090290A (ko) | 2015-12-04 | 2018-08-10 | 시애틀 지네틱스, 인크. | 사차화 튜불리신 화합물들의 컨쥬게이트들 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| CN109843919A (zh) | 2016-03-25 | 2019-06-04 | 西雅图基因公司 | 用于制备聚乙二醇化的药物-接头及其中间体的方法 |
| KR102648564B1 (ko) | 2017-03-24 | 2024-03-19 | 씨젠 인크. | 글루쿠로니드 약물-링커의 제조 공정 및 그 중간물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| AU8052194A (en) * | 1993-10-20 | 1995-05-08 | Enzon, Inc. | 2'- and/or 7- substituted taxoids |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| PT751144E (pt) | 1995-06-27 | 2004-12-31 | Pharmachemie Bv | Novos pro-farmacos antraciclinicos, metodo para preparacao e tambem a sua utilizacao em quimioterapia selectiva |
| JPH1087815A (ja) * | 1996-08-22 | 1998-04-07 | Enzon Inc | ポリアルキレンオキシドカルボン酸の改良製造方法 |
| WO1998013059A1 (en) | 1996-09-27 | 1998-04-02 | Bristol-Myers Squibb Company | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
-
1998
- 1998-07-13 US US09/114,860 patent/US6214330B1/en not_active Expired - Lifetime
-
1999
- 1999-07-12 CA CA002336663A patent/CA2336663C/en not_active Expired - Fee Related
- 1999-07-12 WO PCT/US1999/015652 patent/WO2000002568A1/en not_active Ceased
- 1999-07-12 DK DK99933882T patent/DK1102592T3/da active
- 1999-07-12 EP EP99933882A patent/EP1102592B1/en not_active Expired - Lifetime
- 1999-07-12 AT AT99933882T patent/ATE266424T1/de not_active IP Right Cessation
- 1999-07-12 JP JP2000558827A patent/JP4999226B2/ja not_active Expired - Fee Related
- 1999-07-12 AU AU49839/99A patent/AU4983999A/en not_active Abandoned
- 1999-07-12 DE DE69917281T patent/DE69917281T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000002568A1 (en) | 2000-01-20 |
| JP4999226B2 (ja) | 2012-08-15 |
| EP1102592A1 (en) | 2001-05-30 |
| CA2336663A1 (en) | 2000-01-20 |
| EP1102592A4 (en) | 2001-12-19 |
| AU4983999A (en) | 2000-02-01 |
| ATE266424T1 (de) | 2004-05-15 |
| CA2336663C (en) | 2009-10-20 |
| DE69917281D1 (de) | 2004-06-17 |
| US6214330B1 (en) | 2001-04-10 |
| JP2002520288A (ja) | 2002-07-09 |
| DK1102592T3 (da) | 2004-08-16 |
| EP1102592B1 (en) | 2004-05-12 |
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| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |