DE69910031D1 - Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen - Google Patents
Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungenInfo
- Publication number
- DE69910031D1 DE69910031D1 DE69910031T DE69910031T DE69910031D1 DE 69910031 D1 DE69910031 D1 DE 69910031D1 DE 69910031 T DE69910031 T DE 69910031T DE 69910031 T DE69910031 T DE 69910031T DE 69910031 D1 DE69910031 D1 DE 69910031D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- vitamin
- producing hydroxy
- ene vitamin
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 235000019166 vitamin D Nutrition 0.000 abstract 2
- 239000011710 vitamin D Substances 0.000 abstract 2
- -1 vitamin D compounds Chemical class 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8722298P | 1998-05-29 | 1998-05-29 | |
| US87222P | 1998-05-29 | ||
| PCT/US1999/011950 WO1999061417A2 (en) | 1998-05-29 | 1999-05-28 | Method for making hydroxy-25-ene-vitamin d compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69910031D1 true DE69910031D1 (de) | 2003-09-04 |
| DE69910031T2 DE69910031T2 (de) | 2004-04-29 |
Family
ID=22203846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69910031T Expired - Lifetime DE69910031T2 (de) | 1998-05-29 | 1999-05-28 | Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6441207B1 (de) |
| EP (1) | EP1091936B1 (de) |
| JP (1) | JP2002516306A (de) |
| CN (1) | CN1148347C (de) |
| AT (1) | ATE246172T1 (de) |
| AU (1) | AU755701B2 (de) |
| CA (1) | CA2333256A1 (de) |
| DE (1) | DE69910031T2 (de) |
| ES (1) | ES2204165T3 (de) |
| IL (1) | IL139354A (de) |
| WO (1) | WO1999061417A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1270556A4 (de) * | 2000-03-30 | 2005-01-12 | Teijin Ltd | Vitamin d intermediate und verfahren zu deren herstellung |
| KR100679115B1 (ko) | 2004-11-12 | 2007-02-05 | (주)유케이케미팜 | 1-알파-히드록시콜레칼시페롤 유도체의 제조방법 |
| CA2643714C (en) * | 2006-03-02 | 2014-04-29 | Novozymes Biopolymer A/S | Aryl/alkyl vinyl sulfone hyaluronic acid derivatives |
| WO2010009879A2 (en) * | 2008-07-22 | 2010-01-28 | Azad Pharmaceutical Ingredients Ag | Methods for producing paricalcitol |
| SG173119A1 (en) | 2009-01-27 | 2011-08-29 | Berg Biosystems Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| PL216135B1 (pl) * | 2009-08-07 | 2014-03-31 | Inst Farmaceutyczny | Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D |
| EP3603646B1 (de) | 2009-08-14 | 2024-04-03 | BPGbio, Inc. | Vitamin d3 und analoge davon zur behandlung von alopezie |
| US20130172588A1 (en) * | 2010-09-10 | 2013-07-04 | Genzyme Corporation | Continuous photolytic process for the preparation of vitamin d related substances |
| ES2472241B1 (es) * | 2012-12-27 | 2015-03-09 | Vinas Lab | Procedimiento para obtener compuestos diénicos de configuración trans útiles como intermedios para la síntesis de análogos de vitamina D y uso de un microrreactor correspondiente |
| CN112156097A (zh) | 2013-05-29 | 2021-01-01 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
| EP0028484B1 (de) | 1979-10-23 | 1985-08-14 | Teijin Limited | Verfahren zur Herstellung aktiver Vitamin D3-Verbindungen und von Cholesta-5,7-dien-Vorläufern und so erhaltene Produkte |
| US4310511A (en) | 1980-10-02 | 1982-01-12 | Massachusetts General Hospital | Sunscreen compositions containing Δ5,7 steroidal dienes |
| JPS57149224A (en) | 1981-03-13 | 1982-09-14 | Chugai Pharmaceut Co Ltd | Tumor-suppressing agent |
| US4749710A (en) | 1985-05-01 | 1988-06-07 | Hoffmann-La Roche Inc. | Immunosuppressive agents |
| EP0373687B1 (de) | 1988-12-12 | 1993-06-02 | Duphar International Research B.V | Verfahren zur photochemischen Umwandlung von Tachysterol-Derivaten in Prävitamin D-Derivate und von Transvitamin D-Derivaten in Cisvitamin D-Derivate |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| CA2066716A1 (en) | 1989-09-25 | 1991-03-26 | Raymond A. Daynes | Use of steroid hormones in compositions for inducing t cell lymphokine production |
| US5562910A (en) | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
| US5030772A (en) * | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
| ATE124394T1 (de) | 1990-04-27 | 1995-07-15 | Duphar Int Res | Verfahren zur photochemischen isomerisierung von organischen verbindungen unter dem einfluss eines photosensibilisators. |
| ES2200238T3 (es) * | 1991-01-08 | 2004-03-01 | Bone Care International, Inc. | Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2. |
| IT1247175B (it) | 1991-04-19 | 1994-12-12 | Fidia Spa | Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. |
| GB9220439D0 (en) | 1992-09-28 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
| US5880114A (en) | 1993-06-16 | 1999-03-09 | Wisconsin Alumni Research Foundation | Treatment of immune deficiency with vitamin D compounds |
| US5716946A (en) | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
-
1999
- 1999-05-28 AT AT99953335T patent/ATE246172T1/de not_active IP Right Cessation
- 1999-05-28 JP JP2000550823A patent/JP2002516306A/ja active Pending
- 1999-05-28 EP EP99953335A patent/EP1091936B1/de not_active Expired - Lifetime
- 1999-05-28 IL IL13935499A patent/IL139354A/xx not_active IP Right Cessation
- 1999-05-28 WO PCT/US1999/011950 patent/WO1999061417A2/en active IP Right Grant
- 1999-05-28 DE DE69910031T patent/DE69910031T2/de not_active Expired - Lifetime
- 1999-05-28 CA CA002333256A patent/CA2333256A1/en not_active Abandoned
- 1999-05-28 ES ES99953335T patent/ES2204165T3/es not_active Expired - Lifetime
- 1999-05-28 AU AU43209/99A patent/AU755701B2/en not_active Ceased
- 1999-05-28 CN CNB998067881A patent/CN1148347C/zh not_active Expired - Fee Related
-
2000
- 2000-11-20 US US09/716,316 patent/US6441207B1/en not_active Expired - Lifetime
-
2002
- 2002-08-26 US US10/228,002 patent/US20030009042A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999061417A2 (en) | 1999-12-02 |
| CA2333256A1 (en) | 1999-12-02 |
| IL139354A0 (en) | 2001-11-25 |
| JP2002516306A (ja) | 2002-06-04 |
| EP1091936B1 (de) | 2003-07-30 |
| CN1148347C (zh) | 2004-05-05 |
| WO1999061417A3 (en) | 2000-01-13 |
| DE69910031T2 (de) | 2004-04-29 |
| CN1303369A (zh) | 2001-07-11 |
| AU755701B2 (en) | 2002-12-19 |
| IL139354A (en) | 2005-08-31 |
| AU4320999A (en) | 1999-12-13 |
| ATE246172T1 (de) | 2003-08-15 |
| EP1091936A2 (de) | 2001-04-18 |
| US6441207B1 (en) | 2002-08-27 |
| US20030009042A1 (en) | 2003-01-09 |
| ES2204165T3 (es) | 2004-04-16 |
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