DE69839911D1 - - Google Patents

Info

Publication number
DE69839911D1
DE69839911D1 DE69839911T DE69839911T DE69839911D1 DE 69839911 D1 DE69839911 D1 DE 69839911D1 DE 69839911 T DE69839911 T DE 69839911T DE 69839911 T DE69839911 T DE 69839911T DE 69839911 D1 DE69839911 D1 DE 69839911D1
Authority
DE
Germany
Prior art keywords
cell
sonication
contents
apparatus includes
working electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839911T
Other languages
German (de)
English (en)
Inventor
Jacob N Wohlstadter
James Wilbur
George Sigal
Mark Martin
Alan Fischer
Larry R Helms
Ramin Darvari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meso Scale Technologies LLC
Original Assignee
Meso Scale Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meso Scale Technologies LLC filed Critical Meso Scale Technologies LLC
Application granted granted Critical
Publication of DE69839911D1 publication Critical patent/DE69839911D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69839911T 1997-09-18 1998-09-11 Expired - Lifetime DE69839911D1 (https=)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/932,985 US6413783B1 (en) 1997-09-18 1997-09-18 Assay sonication apparatus and methodology
PCT/US1998/019118 WO1999014599A1 (en) 1997-09-18 1998-09-11 Assay sonication apparatus and methodology

Publications (1)

Publication Number Publication Date
DE69839911D1 true DE69839911D1 (https=) 2008-10-02

Family

ID=25463245

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839911T Expired - Lifetime DE69839911D1 (https=) 1997-09-18 1998-09-11

Country Status (7)

Country Link
US (2) US6413783B1 (https=)
EP (1) EP1018015B1 (https=)
AT (1) ATE405835T1 (https=)
AU (1) AU9774598A (https=)
CA (1) CA2303891C (https=)
DE (1) DE69839911D1 (https=)
WO (1) WO1999014599A1 (https=)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
DE69937747T2 (de) * 1998-10-28 2008-12-04 Covaris, Inc., Woburn Vorrichtung und verfahren zur kontrolle einer akustischen behandlung
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US7687039B2 (en) * 1998-10-28 2010-03-30 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
DE60138934D1 (de) * 2000-02-25 2009-07-23 Hitachi Ltd Mischvorrichtung für Analysenautomat
US20040209303A1 (en) 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
WO2002029076A1 (en) * 2000-10-03 2002-04-11 Mirari Biosciences, Inc. Methods and compositions for directed microwave chemistry
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
JP2004532743A (ja) * 2000-10-25 2004-10-28 ワシントン ステート ユニバーシティ リサーチ ファウンデーション 圧電マイクロトランスデューサ、その使用法および製造法
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
DK1412725T3 (en) 2001-06-29 2019-03-25 Meso Scale Technologies Llc Multi-well plates for LUMINESCENSE TEST MEASUREMENTS
AU2020204526B2 (en) * 2001-06-29 2022-04-07 Meso Scale Technologies, Llc. Assay plates reader systems and methods for luminescence test measurements
EP1412487B1 (en) 2001-07-30 2010-06-16 Meso Scale Technologies LLC Assay electrodes having immobilized lipid/protein layers and methods of making and using the same
AU2002341621A1 (en) 2001-09-10 2003-03-24 Meso Scale Technologies, Llc Methods, reagents, kits and apparatus for protein function analysis
US6939032B2 (en) * 2001-10-25 2005-09-06 Erie Scientific Company Cover slip mixing apparatus
US6838888B2 (en) * 2001-12-13 2005-01-04 Agilent Technologies, Inc. Flow cell humidity sensor system
US20040066703A1 (en) * 2002-10-03 2004-04-08 Protasis Corporation Fluid-handling apparatus and methods
US7000870B2 (en) * 2002-11-07 2006-02-21 Aerion Corporation Laminar flow wing for transonic cruise
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
WO2005056748A1 (en) 2003-12-08 2005-06-23 Covaris, Inc. Apparatus and methods for sample preparation
EP1628136A1 (en) * 2004-08-19 2006-02-22 B.R.A.H.M.S. Aktiengesellschaft Method of diagnosis of disease using copeptin
JP4365813B2 (ja) * 2004-09-22 2009-11-18 オリンパス株式会社 攪拌装置、容器および攪拌装置を備えた分析装置
JP4469928B2 (ja) * 2004-09-22 2010-06-02 ベックマン・コールター・インコーポレーテッド 攪拌容器
SG164389A1 (en) * 2004-12-23 2010-09-29 Hoffmann La Roche Detection of a therapeutic antibody in an experimental animal
GB2426050A (en) 2005-05-09 2006-11-15 Orion Diagnostica Oy Method of measuring binding rate using sonication
US7757561B2 (en) * 2005-08-01 2010-07-20 Covaris, Inc. Methods and systems for processing samples using acoustic energy
US7372562B2 (en) * 2005-10-17 2008-05-13 Hewlett-Packard Development Company, L.P. Dynamic random separation among nanoparticles for nano enhanced Raman spectroscopy (NERS) molecular sensing
US7342656B2 (en) * 2005-10-17 2008-03-11 Hewlett-Packard Development Company, L.P. Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
US10203286B2 (en) 2008-04-11 2019-02-12 Meso Scale Diagnostics, Llc Continuous interleaved process for conducting an assay in a multi-well plate
US20070292844A1 (en) * 2006-03-22 2007-12-20 Northrop Grumman Corporation Enhanced biohazard detection system
WO2008016691A2 (en) * 2006-08-01 2008-02-07 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
EP1925359A1 (en) 2006-11-22 2008-05-28 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy to form particles and particulates
DE102007017450A1 (de) * 2007-04-02 2008-10-09 Niro-Plan Ag Verfahren und Vorrichtung zur Herstellung von Caffe Latte Macchiato
US20100008178A1 (en) * 2008-07-14 2010-01-14 Dale Fahrion Acoustic Beverage Mixer
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
EP2470914B1 (en) 2009-07-27 2020-05-13 Meso Scale Technologies, LLC Assay apparatuses and methods
CN103068852B (zh) 2010-08-17 2016-04-20 弗·哈夫曼-拉罗切有限公司 抗人IgG1抗体
JP5943927B2 (ja) 2010-10-14 2016-07-05 メソ スケール テクノロジーズ エルエルシー アッセイデバイスにおける試薬貯蔵
WO2012051519A2 (en) 2010-10-14 2012-04-19 The Johns Hopkins University Biomarkers of brain injury
BR112013007614B1 (pt) 2010-10-25 2020-12-29 F. Hoffmann-La Roche Ag método para medir um analito, composição reagente, mistura reagente, uso de uma composição reagente, uso de uma amida de ácido carbônico e kit
US8459121B2 (en) 2010-10-28 2013-06-11 Covaris, Inc. Method and system for acoustically treating material
US8709359B2 (en) 2011-01-05 2014-04-29 Covaris, Inc. Sample holder and method for treating sample material
CA2824404C (en) 2011-01-06 2023-01-03 Meso Scale Technologies, Llc Assay cartridges for pcr analysis and methods of use thereof
US20140141458A1 (en) 2011-05-12 2014-05-22 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
EP2776833B1 (en) 2011-11-11 2018-09-05 Eli N. Glezer Co-binder assisted assay methods
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
CA3235305A1 (en) 2013-01-04 2014-07-10 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9789483B2 (en) 2013-03-11 2017-10-17 Cue Inc. System for portable and easy-to-use detection of analytes with mobile computing device
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
DK2972353T3 (da) 2013-03-11 2023-03-27 Meso Scale Technologies Llc Forbedrede fremgangsmåder til udførelse af multipleksanalyser
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
US10202500B2 (en) 2013-03-15 2019-02-12 Lubrizol Advanced Materials, Inc. Heavy metal free CPVC compounds
US10534003B2 (en) 2013-07-17 2020-01-14 The Johns Hopkins University Multi-protein biomarker assay for brain injury detection and outcome
US10300453B2 (en) * 2013-10-16 2019-05-28 University Of Iowa Research Foundation Thin layer sonochemistry and sonoelectrochemistry devices and methods
JP6410422B2 (ja) * 2013-11-25 2018-10-24 株式会社タウンズ タンパク質検出装置およびタンパク質検出方法
CA3229509A1 (en) 2014-05-09 2015-11-12 Meso Scale Technologies, Llc. Graphene-modified electrodes
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
WO2016044697A1 (en) 2014-09-19 2016-03-24 The Johns Hopkins University Biomarkers of cognitive dysfunction
US11041865B2 (en) 2015-02-20 2021-06-22 The Johns Hopkins University Biomarkers of myocardial injury
US10509045B2 (en) 2015-05-29 2019-12-17 University Of Florida Research Foundation, Incorporated Methods for diagnosing Huntington's disease
CA2992596C (en) 2015-07-17 2023-08-22 Cue Inc. Systems and methods for enhanced detection and quantification of analytes
EP3489668B1 (en) * 2015-11-25 2023-03-22 C A Casyso GmbH System for mixing and testing a liquid
WO2017153574A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Branched-chain amines in electrochemiluminescence detection
US10940161B2 (en) 2016-04-04 2021-03-09 University Of Florida Research Foundation, Incorporated Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
WO2018195110A1 (en) 2017-04-17 2018-10-25 University Of Florida Research Foundation, Incorporated Regolation of ran translation by pkr and eif2a-p pathways
WO2018197996A1 (en) 2017-04-24 2018-11-01 Abdolahad Mohammad Ultrasound-assisted electrochemical distinction of normal and cancerous cells
EP3688020A4 (en) 2017-09-25 2021-07-14 University of Florida Research Foundation, Incorporated IMMUNOASSAYS FOR DETECTION OF RAN PROTEINS
AU2018342105B2 (en) 2017-09-26 2023-11-16 University Of Florida Research Foundation, Incorporated Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders
EP4310184A3 (en) 2018-02-23 2024-05-01 Meso Scale Technologies, LLC. Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule
CN112272775A (zh) 2018-06-04 2021-01-26 雅芳产品公司 用于鉴定和治疗衰老皮肤和皮肤病症的蛋白生物标志物
AU2019418498A1 (en) 2019-01-03 2021-07-15 Meso Scale Technologies, Llc Compositions and methods for carrying out assay measurements
CN120098057A (zh) 2019-03-01 2025-06-06 中尺度技术有限责任公司 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒
CN120665985A (zh) 2019-06-07 2025-09-19 豪夫迈·罗氏有限公司 杂交全lna寡核苷酸
IL325928A (en) 2019-07-16 2026-03-01 Meso Scale Technologies Llc Testing instruments, methods and reagents
WO2021055880A1 (en) 2019-09-20 2021-03-25 University Of Florida Researchfoundation, Incorporated Detection of antibodies against ran proteins from serum and tissue lysates
US20240018571A1 (en) 2020-05-19 2024-01-18 Meso Scale Technologies, Llc. Methods, compositions, and kits for nucleic acid detection
EP4176263A1 (en) 2020-07-01 2023-05-10 Meso Scale Technologies, LLC Compositions and methods for assay measurements
EP4222498A4 (en) 2020-09-29 2024-10-16 The Johns Hopkins University INTEGRATED PROTEOMIC BIOMARKERS FOR THE DETECTION OF AGGRESSIVE PROSTATE CANCER
JP2023554517A (ja) 2020-12-22 2023-12-27 エフ． ホフマン－ラ ロシュ アーゲー 試料中の目的の分析物を検出するための方法
CN118922555A (zh) 2021-12-30 2024-11-08 中尺度技术有限责任公司 用于电化学发光检测的方法
JP2025506652A (ja) 2022-02-18 2025-03-13 エフ． ホフマン－ラ ロシュ アーゲー 試料中の目的の分析物を検出するための方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1063486A (en) * 1976-04-22 1979-10-02 Bristol-Myers Squibb Company Ultrasonic cleaner
US4575485A (en) * 1983-08-29 1986-03-11 Syntex (U.S.A.) Inc. Ultrasonic enhanced immuno-reactions
US4983523A (en) * 1988-04-08 1991-01-08 Gene-Trak Systems Methods for preparing sample nucleic acids for hybridization
JPH02312591A (ja) * 1989-05-26 1990-12-27 Chisso Corp 超音波による酵素反応の制御法
US5247954A (en) * 1991-11-12 1993-09-28 Submicron Systems, Inc. Megasonic cleaning system
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5866434A (en) * 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions

Also Published As

Publication number Publication date
ATE405835T1 (de) 2008-09-15
WO1999014599A1 (en) 1999-03-25
EP1018015B1 (en) 2008-08-20
CA2303891A1 (en) 1999-03-25
CA2303891C (en) 2009-11-17
EP1018015A1 (en) 2000-07-12
US7008796B2 (en) 2006-03-07
US20020137234A1 (en) 2002-09-26
AU9774598A (en) 1999-04-05
US6413783B1 (en) 2002-07-02
EP1018015A4 (en) 2005-10-19

Similar Documents

Publication Publication Date Title
DE69839911D1 (https=)
DE69534599D1 (en) Intrazellulare expression von carboxypeptidase g2 in enzyme-prodrug-therapie
FI951814A7 (fi) Sähkökemiallinen laite energian luovuttamiseksi käyttäen ilmaelektrodia
GB9325775D0 (en) Electrochemical gas sensor with wraparound reference electrode
AU699526B3 (en) Power supply device
AU4919199A (en) Electrochemiluminescence cell with floating reaction electrodes
AU4020395A (en) Power supply for portable devices
CA2313761A1 (en) Spatial awareness device
AUPO910097A0 (en) Power generation process and apparatus
EP0651262A3 (en) Portable battery-operated device with battery tester.
GB2306761B (en) Electrode materials suitable for electrochemical cells
KR900007424U (ko) 보조전극을 설치한 플라즈마 표시소자
ZA966120B (en) Device adapted to be fixed and sealed to at least one cylindrical member.
SG44890A1 (en) An environmentally friendly and space efficient battery package
GB9727172D0 (en) Reagents specific for st2l and uses therefor
DE69307644D1 (de) Kathodenmaterial und dieses verwendende Sekundärbatterie
AU6123398A (en) Loading unit for air freight
AU2046299A (en) Method and device for improving the efficiency of active agents consisting at least of mineral substances
GB2284599A8 (en) Solid-electrolyte fuel cell electrode material andelectrode using same
ZA969222B (en) Flotation cell crowder device
JPS5616863A (en) Electrode unit
GB2343211A (en) Line marking apparatus
KR970060548A (ko) 전지삽입장치
JPS5391414A (en) Electric strain vibrator fitting tool for liquid atomizer
AU8732098A (en) A device and a process for the locating of an interrupt request allocated to a source

Legal Events

Date Code Title Description
8364 No opposition during term of opposition