DE69839911D1 - - Google Patents

Info

Publication number
DE69839911D1
DE69839911D1 DE69839911T DE69839911T DE69839911D1 DE 69839911 D1 DE69839911 D1 DE 69839911D1 DE 69839911 T DE69839911 T DE 69839911T DE 69839911 T DE69839911 T DE 69839911T DE 69839911 D1 DE69839911 D1 DE 69839911D1
Authority
DE
Germany
Prior art keywords
cell
sonication
contents
apparatus includes
working electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839911T
Other languages
English (en)
Inventor
Jacob N Wohlstadter
James Wilbur
George Sigal
Mark Martin
Alan Fischer
Larry R Helms
Ramin Darvari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meso Scale Technologies LLC
Original Assignee
Meso Scale Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meso Scale Technologies LLC filed Critical Meso Scale Technologies LLC
Application granted granted Critical
Publication of DE69839911D1 publication Critical patent/DE69839911D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69839911T 1997-09-18 1998-09-11 Expired - Lifetime DE69839911D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/932,985 US6413783B1 (en) 1997-09-18 1997-09-18 Assay sonication apparatus and methodology
PCT/US1998/019118 WO1999014599A1 (en) 1997-09-18 1998-09-11 Assay sonication apparatus and methodology

Publications (1)

Publication Number Publication Date
DE69839911D1 true DE69839911D1 (de) 2008-10-02

Family

ID=25463245

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839911T Expired - Lifetime DE69839911D1 (de) 1997-09-18 1998-09-11

Country Status (7)

Country Link
US (2) US6413783B1 (de)
EP (1) EP1018015B1 (de)
AT (1) ATE405835T1 (de)
AU (1) AU9774598A (de)
CA (1) CA2303891C (de)
DE (1) DE69839911D1 (de)
WO (1) WO1999014599A1 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6719449B1 (en) * 1998-10-28 2004-04-13 Covaris, Inc. Apparatus and method for controlling sonic treatment
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US7687039B2 (en) * 1998-10-28 2010-03-30 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
DE60138934D1 (de) * 2000-02-25 2009-07-23 Hitachi Ltd Mischvorrichtung für Analysenautomat
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
US20040209303A1 (en) 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
EP1330532B1 (de) * 2000-10-03 2011-12-14 Mirari Biosciences, Inc. Verfahren und zusammensetzungen für die gerichtete mikrowellenchemiie
EP1350276A2 (de) * 2000-10-25 2003-10-08 Washington State University Research Foundation Piezoelektrischer mikro-wandler sowie deren verwendungs- und herstellungsverfahren
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
DK2461156T3 (da) 2001-06-29 2020-08-03 Meso Scale Technologies Llc Indretning til luminescenstestmålinger
AU2020204526B2 (en) * 2001-06-29 2022-04-07 Meso Scale Technologies, Llc. Assay plates reader systems and methods for luminescence test measurements
AU2002365119A1 (en) 2001-07-30 2003-09-04 Meso Scale Technologies, Llc. Assay electrodes having immobilized lipid/protein layers and methods of making and using the same
CA2459893C (en) 2001-09-10 2014-01-21 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
US6939032B2 (en) * 2001-10-25 2005-09-06 Erie Scientific Company Cover slip mixing apparatus
US6838888B2 (en) * 2001-12-13 2005-01-04 Agilent Technologies, Inc. Flow cell humidity sensor system
US20040066703A1 (en) * 2002-10-03 2004-04-08 Protasis Corporation Fluid-handling apparatus and methods
US7000870B2 (en) * 2002-11-07 2006-02-21 Aerion Corporation Laminar flow wing for transonic cruise
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
US7981362B2 (en) * 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
EP1694814A1 (de) 2003-12-08 2006-08-30 Covaris, Inc. Vorrichtungen und verfahren zur probenvorbereitung
EP1628136A1 (de) * 2004-08-19 2006-02-22 B.R.A.H.M.S. Aktiengesellschaft Diagnoseverfahren für Krankheiten unter Verwendung von Copeptin
JP4365813B2 (ja) * 2004-09-22 2009-11-18 オリンパス株式会社 攪拌装置、容器および攪拌装置を備えた分析装置
JP4469928B2 (ja) * 2004-09-22 2010-06-02 ベックマン・コールター・インコーポレーテッド 攪拌容器
RU2393483C2 (ru) * 2004-12-23 2010-06-27 Ф.Хоффманн-Ля Рош Аг Детекция терапевтического антитела у экспериментального животного
GB2426050A (en) * 2005-05-09 2006-11-15 Orion Diagnostica Oy Method of measuring binding rate using sonication
US7757561B2 (en) * 2005-08-01 2010-07-20 Covaris, Inc. Methods and systems for processing samples using acoustic energy
US7372562B2 (en) * 2005-10-17 2008-05-13 Hewlett-Packard Development Company, L.P. Dynamic random separation among nanoparticles for nano enhanced Raman spectroscopy (NERS) molecular sensing
US7342656B2 (en) * 2005-10-17 2008-03-11 Hewlett-Packard Development Company, L.P. Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
US20070292844A1 (en) * 2006-03-22 2007-12-20 Northrop Grumman Corporation Enhanced biohazard detection system
WO2008016691A2 (en) * 2006-08-01 2008-02-07 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
EP1925359A1 (de) 2006-11-22 2008-05-28 Covaris, Inc. Verfahren und Vorrichtungen zur Behandlung von Proben mit akustischer Energie zur Bildung von Partikeln
DE102007017450A1 (de) * 2007-04-02 2008-10-09 Niro-Plan Ag Verfahren und Vorrichtung zur Herstellung von Caffe Latte Macchiato
DK3567363T3 (da) 2008-04-11 2022-04-25 Meso Scale Technologies Llc Prøvningsindretninger, -fremgangsmåder og reagenser
US20100008178A1 (en) * 2008-07-14 2010-01-14 Dale Fahrion Acoustic Beverage Mixer
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
CA2769380C (en) 2009-07-27 2020-08-25 Meso Scale Technologies, Llc Assay apparatuses, consumables and methods
RU2603284C2 (ru) 2010-08-17 2016-11-27 Ф.Хоффманн-Ля Рош Аг АНТИТЕЛА ПРОТИВ IgG1 ЧЕЛОВЕКА
EP4300100A2 (de) 2010-10-14 2024-01-03 Meso Scale Technologies, LLC Reagenzienlagerung in einer assay-vorrichtung
EP2628013B1 (de) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarker für gehirnverletzungen
SG189113A1 (en) 2010-10-25 2013-05-31 Hoffmann La Roche Use of signal enhancing compounds in electrochemiluminescence detection
US8459121B2 (en) 2010-10-28 2013-06-11 Covaris, Inc. Method and system for acoustically treating material
US8709359B2 (en) 2011-01-05 2014-04-29 Covaris, Inc. Sample holder and method for treating sample material
WO2012094459A2 (en) 2011-01-06 2012-07-12 Glezer Eli N Assay cartridges and methods of using the same
US20140141458A1 (en) 2011-05-12 2014-05-22 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
DK3467500T3 (da) 2011-11-11 2021-08-16 Eli N Glezer Cobinder-understøttede assayfremgangsmåder
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
AU2014203992B2 (en) 2013-01-04 2018-03-22 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
JP6791750B2 (ja) 2013-03-11 2020-11-25 メソ スケール テクノロジーズ エルエルシー 多重化アッセイを行うための改良された方法
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
EP2861996B1 (de) 2013-03-11 2019-03-06 Cue Health Inc. Probenanalyse-kartusche
KR102257912B1 (ko) 2013-03-13 2021-05-27 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
WO2014143623A1 (en) 2013-03-15 2014-09-18 The Lubrizol Corporation Heavy metal free cpvc compositions
EP3022322A4 (de) 2013-07-17 2017-05-17 The Johns Hopkins University Multiprotein-biomarkertest für den nachweis von hirnläsionen und ergebnis
US10300453B2 (en) * 2013-10-16 2019-05-28 University Of Iowa Research Foundation Thin layer sonochemistry and sonoelectrochemistry devices and methods
JP6410422B2 (ja) * 2013-11-25 2018-10-24 株式会社タウンズ タンパク質検出装置およびタンパク質検出方法
CA2947747C (en) 2014-05-09 2024-03-05 Meso Scale Technologies, Llc. Graphene-modified electrodes
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
EP3143401A4 (de) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Verbesserte testverfahren
WO2016044697A1 (en) 2014-09-19 2016-03-24 The Johns Hopkins University Biomarkers of cognitive dysfunction
WO2016134365A1 (en) 2015-02-20 2016-08-25 The Johns Hopkins University Biomarkers of myocardial injury
EP3689466B1 (de) 2015-07-17 2024-06-05 Cue Health Inc. System zur erweiterten detektion und quantifizierung von analyten
EP3173776B1 (de) * 2015-11-25 2019-01-16 C A Casyso GmbH Vorrichtung und verfahren zur mischung und zum testen einer flüssigkeit
WO2017153574A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Branched-chain amines in electrochemiluminescence detection
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
WO2018197996A1 (en) * 2017-04-24 2018-11-01 Abdolahad Mohammad Ultrasound-assisted electrochemical distinction of normal and cancerous cells
EP3688021A4 (de) 2017-09-26 2021-12-29 University of Florida Research Foundation, Incorporated Verwendung von metformin und analoga davon zur verminderung von ran-preotein-spiegeln in der behandlung von neurologischen störungen
FI3756009T3 (fi) 2018-02-23 2023-12-01 Meso Scale Technologies Llc Menetelmiä antigeeniä sitovien molekyylien seulontaan normalisoimalla antigeeniä sitovan molekyylin pitoisuus
EP3803415A1 (de) 2018-06-04 2021-04-14 Avon Products, Inc. Proteinbiomarker zur identifizierung und behandlung von alternder haut und hautkrankheiten
EP3906412A1 (de) 2019-01-03 2021-11-10 Meso Scale Technologies, LLC Zusammensetzungen und verfahren zur durchführung von testmessungen
JP2022522480A (ja) 2019-03-01 2022-04-19 メソ スケール テクノロジーズ エルエルシー 免疫測定法で使用するための電気化学発光標識プローブ、当該プローブを使用する方法および該プローブを含むキット
KR20220005571A (ko) 2019-06-07 2022-01-13 에프. 호프만-라 로슈 아게 전부 lna 올리고뉴클레오티드 혼성화
US20240018571A1 (en) 2020-05-19 2024-01-18 Meso Scale Technologies, Llc. Methods, compositions, and kits for nucleic acid detection
IL299495A (en) 2020-07-01 2023-02-01 Meso Scale Technologies Llc Compositions and methods for making measurements
WO2022136234A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Method for detecting an analyte of interest in a sample
US20230279290A1 (en) 2021-12-30 2023-09-07 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
WO2023156510A1 (en) 2022-02-18 2023-08-24 F. Hoffmann-La Roche Ag Method for detecting an analyte of interest in a sample

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1063486A (en) * 1976-04-22 1979-10-02 Bristol-Myers Squibb Company Ultrasonic cleaner
US4575485A (en) * 1983-08-29 1986-03-11 Syntex (U.S.A.) Inc. Ultrasonic enhanced immuno-reactions
US4983523A (en) * 1988-04-08 1991-01-08 Gene-Trak Systems Methods for preparing sample nucleic acids for hybridization
JPH02312591A (ja) * 1989-05-26 1990-12-27 Chisso Corp 超音波による酵素反応の制御法
US5247954A (en) * 1991-11-12 1993-09-28 Submicron Systems, Inc. Megasonic cleaning system
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5866434A (en) * 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions

Also Published As

Publication number Publication date
US20020137234A1 (en) 2002-09-26
ATE405835T1 (de) 2008-09-15
US7008796B2 (en) 2006-03-07
EP1018015A4 (de) 2005-10-19
AU9774598A (en) 1999-04-05
US6413783B1 (en) 2002-07-02
CA2303891C (en) 2009-11-17
WO1999014599A1 (en) 1999-03-25
CA2303891A1 (en) 1999-03-25
EP1018015A1 (de) 2000-07-12
EP1018015B1 (de) 2008-08-20

Similar Documents

Publication Publication Date Title
DE69839911D1 (de)
DE69534599D1 (en) Intrazellulare expression von carboxypeptidase g2 in enzyme-prodrug-therapie
GB2273988B (en) Electrochemical gas sensor with wraparound reference electrode
EP0763462A4 (de) Hilfsantrieb für fahrräder und fahrrad mit solchem hilfsantrieb
AU4919199A (en) Electrochemiluminescence cell with floating reaction electrodes
UA29511C2 (en) Method and device for electrochemical working by bipolar pulses and power source used in the method
DE69321477T2 (de) Vorrichtung zum wiederaufladen von batteriebetriebenen elektrischen geräte
EP0750359A3 (de) Sekundärbatterie mit Elektroden die ein mehrphasiges, poröses aktives Material enthalten
CA2313761A1 (en) Spatial awareness device
AUPO910097A0 (en) Power generation process and apparatus
EP0651262A3 (de) Batteriebetriebene portable Geräte mit Batterietestern.
KR900007424U (ko) 보조전극을 설치한 플라즈마 표시소자
HK1014223A1 (en) Power generating device
ZA966120B (en) Device adapted to be fixed and sealed to at least one cylindrical member.
SG44890A1 (en) An environmentally friendly and space efficient battery package
GB9727172D0 (en) Reagents specific for st2l and uses therefor
EP0703182A3 (de) Energiesparvorrichtung für einen Aufzug
AU6123398A (en) Loading unit for air freight
ZA945105B (en) Device for the generation of energy
AU2046299A (en) Method and device for improving the efficiency of active agents consisting at least of mineral substances
GB2284599A8 (en) Solid-electrolyte fuel cell electrode material andelectrode using same
JPS5616863A (en) Electrode unit
DE59606757D1 (de) Vorrichtung zum ausgerichteten Zuführen und Auflockern von Stapeln flacher Gegenstände
GB2343211A (en) Line marking apparatus
ATE266587T1 (de) Vorrichtung zum bereitstellen von material an arbeitsplätzen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition