DE69839911D1 - - Google Patents

Info

Publication number
DE69839911D1
DE69839911D1 DE69839911T DE69839911T DE69839911D1 DE 69839911 D1 DE69839911 D1 DE 69839911D1 DE 69839911 T DE69839911 T DE 69839911T DE 69839911 T DE69839911 T DE 69839911T DE 69839911 D1 DE69839911 D1 DE 69839911D1
Authority
DE
Germany
Prior art keywords
cell
sonication
contents
apparatus includes
working electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839911T
Other languages
German (de)
English (en)
Inventor
Jacob N Wohlstadter
James Wilbur
George Sigal
Mark Martin
Alan Fischer
Larry R Helms
Ramin Darvari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meso Scale Technologies LLC
Original Assignee
Meso Scale Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meso Scale Technologies LLC filed Critical Meso Scale Technologies LLC
Application granted granted Critical
Publication of DE69839911D1 publication Critical patent/DE69839911D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69839911T 1997-09-18 1998-09-11 Expired - Lifetime DE69839911D1 (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/932,985 US6413783B1 (en) 1997-09-18 1997-09-18 Assay sonication apparatus and methodology
PCT/US1998/019118 WO1999014599A1 (en) 1997-09-18 1998-09-11 Assay sonication apparatus and methodology

Publications (1)

Publication Number Publication Date
DE69839911D1 true DE69839911D1 (enExample) 2008-10-02

Family

ID=25463245

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839911T Expired - Lifetime DE69839911D1 (enExample) 1997-09-18 1998-09-11

Country Status (7)

Country Link
US (2) US6413783B1 (enExample)
EP (1) EP1018015B1 (enExample)
AT (1) ATE405835T1 (enExample)
AU (1) AU9774598A (enExample)
CA (1) CA2303891C (enExample)
DE (1) DE69839911D1 (enExample)
WO (1) WO1999014599A1 (enExample)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US7687039B2 (en) 1998-10-28 2010-03-30 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
EP1125121B1 (en) * 1998-10-28 2007-12-12 Covaris, Inc. Apparatus and methods for controlling sonic treatment
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
DE60138934D1 (de) * 2000-02-25 2009-07-23 Hitachi Ltd Mischvorrichtung für Analysenautomat
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
JP4833498B2 (ja) * 2000-10-03 2011-12-07 ミラリ バイオサイエンシズ，インコーポレーテッド 指向性マイクロ波化学のための方法および組成物
US20040209303A1 (en) 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
EP1350276A2 (en) * 2000-10-25 2003-10-08 Washington State University Research Foundation Piezoelectric micro-transducers, methods of use and manufacturing methods for same
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
DK1412725T3 (en) * 2001-06-29 2019-03-25 Meso Scale Technologies Llc Multi-well plates for LUMINESCENSE TEST MEASUREMENTS
AU2020204526B2 (en) * 2001-06-29 2022-04-07 Meso Scale Technologies, Llc. Assay plates reader systems and methods for luminescence test measurements
DK1412487T3 (da) 2001-07-30 2010-08-30 Meso Scale Technologies Llc Assayelektroder der har immobiliserede lipid/proteinlag og fremgangsmåder til at fremstille og anvende disse
WO2003023360A2 (en) 2001-09-10 2003-03-20 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
US6939032B2 (en) * 2001-10-25 2005-09-06 Erie Scientific Company Cover slip mixing apparatus
US6838888B2 (en) * 2001-12-13 2005-01-04 Agilent Technologies, Inc. Flow cell humidity sensor system
US20040066703A1 (en) * 2002-10-03 2004-04-08 Protasis Corporation Fluid-handling apparatus and methods
US7000870B2 (en) * 2002-11-07 2006-02-21 Aerion Corporation Laminar flow wing for transonic cruise
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
EP1694814A1 (en) 2003-12-08 2006-08-30 Covaris, Inc. Apparatus and methods for sample preparation
EP1628136A1 (en) * 2004-08-19 2006-02-22 B.R.A.H.M.S. Aktiengesellschaft Method of diagnosis of disease using copeptin
JP4469928B2 (ja) * 2004-09-22 2010-06-02 ベックマン・コールター・インコーポレーテッド 攪拌容器
JP4365813B2 (ja) * 2004-09-22 2009-11-18 オリンパス株式会社 攪拌装置、容器および攪拌装置を備えた分析装置
BRPI0519354B8 (pt) * 2004-12-23 2021-07-27 Hoffmann La Roche método para detecção de um anticorpo terapêutico e uso de um anticorpo
GB2426050A (en) 2005-05-09 2006-11-15 Orion Diagnostica Oy Method of measuring binding rate using sonication
WO2007016605A2 (en) * 2005-08-01 2007-02-08 Covaris, Inc. An apparatus and a method for processing a sample using acoustic energy
US7372562B2 (en) * 2005-10-17 2008-05-13 Hewlett-Packard Development Company, L.P. Dynamic random separation among nanoparticles for nano enhanced Raman spectroscopy (NERS) molecular sensing
US7342656B2 (en) * 2005-10-17 2008-03-11 Hewlett-Packard Development Company, L.P. Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
US20070292844A1 (en) * 2006-03-22 2007-12-20 Northrop Grumman Corporation Enhanced biohazard detection system
US8353619B2 (en) * 2006-08-01 2013-01-15 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
EP1925359A1 (en) 2006-11-22 2008-05-28 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy to form particles and particulates
DE102007017450A1 (de) * 2007-04-02 2008-10-09 Niro-Plan Ag Verfahren und Vorrichtung zur Herstellung von Caffe Latte Macchiato
CA2721327C (en) 2008-04-11 2020-01-07 Meso Scale Technologies, Llc Assay apparatuses, methods and reagents
US20100008178A1 (en) * 2008-07-14 2010-01-14 Dale Fahrion Acoustic Beverage Mixer
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
CA3203856A1 (en) * 2009-07-27 2011-02-10 Meso Scale Technologies, Llc Assay apparatuses, consumables and methods
RU2603284C2 (ru) 2010-08-17 2016-11-27 Ф.Хоффманн-Ля Рош Аг АНТИТЕЛА ПРОТИВ IgG1 ЧЕЛОВЕКА
CA3139049C (en) 2010-10-14 2024-10-15 Meso Scale Technologies Llc Reagent storage in an assay device
EP2628013B1 (en) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarkers of brain injury
HUE029030T2 (en) 2010-10-25 2017-01-30 Hoffmann La Roche Use of signal repair compounds for electrochemiluminescence detection
US8459121B2 (en) 2010-10-28 2013-06-11 Covaris, Inc. Method and system for acoustically treating material
US8709359B2 (en) 2011-01-05 2014-04-29 Covaris, Inc. Sample holder and method for treating sample material
EP2661485A4 (en) 2011-01-06 2018-11-21 Meso Scale Technologies, LLC Assay cartridges and methods of using the same
EP2707389B1 (en) 2011-05-12 2019-10-30 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
ES2700792T3 (es) 2011-11-11 2019-02-19 Eli N Glezer Procedimientos de ensayo asistidos por coagente de unión
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
CN105209886B (zh) 2013-01-04 2019-04-02 梅索磅秤技术有限公司 适合询问样品的仪器和方法
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
WO2014164594A1 (en) 2013-03-11 2014-10-09 Meso Scale Technologies, Llc. Improved methods for conducting multiplexed assays
CN112782393B (zh) 2013-03-11 2024-11-19 克忧健康公司 用于检测和量化分析物的系统和方法
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
AU2014248759B2 (en) 2013-03-13 2020-02-27 Meso Scale Technologies, Llc. Improved assay methods
WO2014143623A1 (en) 2013-03-15 2014-09-18 The Lubrizol Corporation Heavy metal free cpvc compositions
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
US10300453B2 (en) * 2013-10-16 2019-05-28 University Of Iowa Research Foundation Thin layer sonochemistry and sonoelectrochemistry devices and methods
JP6410422B2 (ja) * 2013-11-25 2018-10-24 株式会社タウンズ タンパク質検出装置およびタンパク質検出方法
CA2947747C (en) 2014-05-09 2024-03-05 Meso Scale Technologies, Llc. Graphene-modified electrodes
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
US10222386B2 (en) 2014-09-19 2019-03-05 The Johns Hopkins University Biomarkers of congnitive dysfunction
EP3259594A4 (en) 2015-02-20 2018-12-26 The Johns Hopkins University Biomarkers of myocardial injury
WO2016196324A1 (en) 2015-05-29 2016-12-08 University Of Floridia Research Foundation, Inc. Methods for diagnosing huntington's disease
EP3325153B1 (en) 2015-07-17 2020-03-18 Cue Health Inc. Sample analysis cartridge
EP3489668B1 (en) * 2015-11-25 2023-03-22 C A Casyso GmbH System for mixing and testing a liquid
WO2017153574A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Branched-chain amines in electrochemiluminescence detection
US10940161B2 (en) 2016-04-04 2021-03-09 University Of Florida Research Foundation, Incorporated Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
JP7526455B2 (ja) 2017-04-17 2024-08-01 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． ＰＫＲおよびｅＩＦ２Ａ－Ｐ経路によるＲＡＮタンパク質翻訳の調節
WO2018197996A1 (en) 2017-04-24 2018-11-01 Abdolahad Mohammad Ultrasound-assisted electrochemical distinction of normal and cancerous cells
JP7350337B2 (ja) 2017-09-26 2023-09-26 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 神経障害の処置においてｒａｎタンパク質レベルを低下させるためのメトホルミンおよびそのアナログの使用
FI3756009T3 (fi) 2018-02-23 2023-12-01 Meso Scale Technologies Llc Menetelmiä antigeeniä sitovien molekyylien seulontaan normalisoimalla antigeeniä sitovan molekyylin pitoisuus
EP3803415A1 (en) 2018-06-04 2021-04-14 Avon Products, Inc. Protein biomarkers for identifying and treating aging skin and skin conditions
SG11202106924VA (en) 2019-01-03 2021-07-29 Meso Scale Technologies Llc Compositions and methods for carrying out assay measurements
CN120098057A (zh) 2019-03-01 2025-06-06 中尺度技术有限责任公司 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒
BR112021024624A2 (pt) 2019-06-07 2022-01-18 Hoffmann La Roche Métodos para selecionar e fornecer um par de ligação de oligonucleotídeos de fita simples, para formar um duplex antiparalelo e para realizar um ensaio, par de ss-oligonucleotídeos complementares separados, duplex antiparalelo, uso de um par de ss-oligonucleotídeos separados, kit para realizar um ensaio e composição líquida
SG11202111169YA (en) 2019-07-16 2021-11-29 Meso Scale Technologies Llc Assay apparatuses, methods and reagents
JP7620988B2 (ja) 2019-09-20 2025-01-24 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 血清および組織ライセートからのｒａｎタンパク質に対する抗体の検出
EP4154008A1 (en) 2020-05-19 2023-03-29 Meso Scale Technologies, LLC Methods, compositions, and kits for nucleic acid detection
AU2021299536A1 (en) 2020-07-01 2023-02-16 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
WO2022072479A1 (en) 2020-09-29 2022-04-07 The Johns Hopkins University Integrated proteomic biomarkers for the detection of aggressive prostate cancer
CN116635083A (zh) 2020-12-22 2023-08-22 豪夫迈·罗氏有限公司 用于检测样品中的目标分析物的方法
IL313927A (en) 2021-12-30 2024-08-01 Meso Scale Technologies Llc Methods for detection using electrochemiluminescence
JP2025506652A (ja) 2022-02-18 2025-03-13 エフ． ホフマン－ラ ロシュ アーゲー 試料中の目的の分析物を検出するための方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1063486A (en) * 1976-04-22 1979-10-02 Bristol-Myers Squibb Company Ultrasonic cleaner
US4575485A (en) * 1983-08-29 1986-03-11 Syntex (U.S.A.) Inc. Ultrasonic enhanced immuno-reactions
US4983523A (en) * 1988-04-08 1991-01-08 Gene-Trak Systems Methods for preparing sample nucleic acids for hybridization
JPH02312591A (ja) * 1989-05-26 1990-12-27 Chisso Corp 超音波による酵素反応の制御法
US5247954A (en) * 1991-11-12 1993-09-28 Submicron Systems, Inc. Megasonic cleaning system
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5866434A (en) * 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions

Also Published As

Publication number Publication date
US6413783B1 (en) 2002-07-02
EP1018015A1 (en) 2000-07-12
EP1018015A4 (en) 2005-10-19
WO1999014599A1 (en) 1999-03-25
AU9774598A (en) 1999-04-05
ATE405835T1 (de) 2008-09-15
CA2303891A1 (en) 1999-03-25
CA2303891C (en) 2009-11-17
US20020137234A1 (en) 2002-09-26
US7008796B2 (en) 2006-03-07
EP1018015B1 (en) 2008-08-20

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